公开(公告)号：US20240238439A1

公开(公告)日：2024-07-18

申请号：US18403476

申请日：2024-01-03

Applicant: Hummingbird Bioscience Pte. Ltd.

Inventor： Suhail Ahmed Kabeer Rasheed ,  Dipti Thakkar ,  Shalini Paliwal ,  Wen Jie Chin ,  Akshaya Bansal ,  Benjamin Ayers ,  Cheng Theng Ng ,  Brendon Hanson ,  Piers Ingram ,  Jerome Boyd-Kirkup

IPC: A61K47/68 ,  A61P35/00 ,  G01N33/574

CPC classification number: A61K47/6851 ,  A61K47/68037 ,  A61K47/6889 ,  A61P35/00 ,  G01N33/5748 ,  G01N2333/82

Abstract: Methods of treating cancer are provided, as well as compositions including an antigen-binding molecule that binds to HER3, comprising (i) a HER3-binding moiety, and (ii) a linker-payload moiety comprising exatecan or a derivative thereof.