公开(公告)号：US20100249194A1

公开(公告)日：2010-09-30

申请号：US12814289

申请日：2010-06-11

申请人： Hyoung Ik Lee ,  Loïc Patrick Le Hir de Fallois ,  Philip Reid Timmons ,  William Glenn Cawthorne, JR. ,  Adalberto Perez de Leon

发明人： Hyoung Ik Lee ,  Loïc Patrick Le Hir de Fallois ,  Philip Reid Timmons ,  William Glenn Cawthorne, JR. ,  Adalberto Perez de Leon

IPC分类号： A61K31/4439 ,  A61K31/415

CPC分类号： A01N43/56 ,  A01N25/02 ,  A01N47/02 ,  A61K31/415 ,  A61K31/4439 ,  A61K45/06 ,  C07D231/18 ,  C07D401/04

摘要： Provided are 1-aryl-5-alkyl pyrazole compounds, of formula (I): wherein: R1 is hydrogen, cyano, halogen, R8, formyl, —C(O)R8, —C(O)OR8, —C(O)NR9R10, or —C(S)NH2; R2 is R8 or —S(O)mR11; R3 is methyl, ethyl or C1-C4 haloalkyl; R4, R5 and R7 are independently hydrogen, halogen, alkyl, haloalkyl, cyano or nitro; R6 is halogen, alkyl, haloalkyl, alkoxy, haloalkyloxy, cyano, nitro, —C(O)R12, —S(O)nR12 or SF5; Z is a nitrogen atom or C—R13; R8 is alkyl, haloalkyl, cycloalkyl or halocycloalkyl; R9 is hydrogen, alkyl, haloalkyl or alkoxy; R10 is hydrogen, alkyl, haloalkyl or alkoxy; R11 is alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, haloalkynyl or cycloalkyl; R12 is alkyl or haloalkyl; R13 is hydrogen, halogen, cyano, nitro, alkyl, haloalkyl, alkoxy or haloalkoxy; m is 0, 1 or 2; and n is 0, 1 or 2; or a salt thereof, the method of making compounds of formula (I) and the use of these compounds against ectoparasites, endoparasites and pests.

摘要翻译： 提供式（I）的1-芳基-5-烷基吡唑化合物：其中：R 1是氢，氰基，卤素，R 8，甲酰基，-C（O）R 8，-C（O）OR 8，-C ）NR 9 R 10或-C（S）NH 2; R2是R8或-S（O）mR11; R3是甲基，乙基或C1-C4卤代烷基; R4，R5和R7独立地是氢，卤素，烷基，卤代烷基，氰基或硝基; R 6是卤素，烷基，卤代烷基，烷氧基，卤代烷氧基，氰基，硝基，-C（O）R 12，-S（O）n R 12或SF 5; Z是氮原子或C-R13; R8是烷基，卤代烷基，环烷基或卤代环烷基; R9是氢，烷基，卤代烷基或烷氧基; R 10是氢，烷基，卤代烷基或烷氧基; R11是烷基，卤代烷基，烯基，卤代烯基，炔基，卤代炔基或环烷基; R12是烷基或卤代烷基; R 13是氢，卤素，氰基，硝基，烷基，卤代烷基，烷氧基或卤代烷氧基; m为0,1或2; 且n为0,1或2; 或其盐，制备式（I）化合物的方法以及这些化合物对外寄生虫，内寄生虫和害虫的用途。