-
公开(公告)号：US12049439B2
公开(公告)日：2024-07-30
申请号：US17463011
申请日：2021-08-31
申请人： OrsoBio, Inc.
发明人： Julie Farand , Joshua A. Kaplan , Gregory Notte , Casey Lockwood Olen , Michael Sangi , David Sperandio
IPC分类号： C07C323/25 , A61K31/18 , A61P1/16 , C07C311/08 , C07C311/13 , C07C311/14 , C07C311/21 , C07C311/29 , C07C311/39 , C07C311/46 , C07C313/06 , C07C323/30 , C07C323/31 , C07D205/04 , C07D207/48 , C07D213/89 , C07D231/18 , C07D235/00 , C07D239/26 , C07D257/04 , C07D275/02 , C07D277/36 , C07D279/12 , C07D295/116 , C07D305/08 , C07D309/08 , C07D335/02 , C07D451/02 , C07D493/08 , C07F9/50
CPC分类号： C07C323/25 , A61K31/18 , A61P1/16 , C07C311/08 , C07C311/13 , C07C311/14 , C07C311/21 , C07C311/29 , C07C311/39 , C07C311/46 , C07C313/06 , C07C323/30 , C07C323/31 , C07D205/04 , C07D207/48 , C07D213/89 , C07D231/18 , C07D235/00 , C07D239/26 , C07D257/04 , C07D275/02 , C07D277/36 , C07D279/12 , C07D295/116 , C07D305/08 , C07D309/08 , C07D335/02 , C07D451/02 , C07D493/08 , C07F9/5022
摘要： Provided is a compound of Formula (I):
wherein the variable groups are defined herein.-
公开(公告)号：US11884633B2
公开(公告)日：2024-01-30
申请号：US17488083
申请日：2021-09-28
IPC分类号： C07D231/12 , C07D403/12 , A01N43/50 , A01N43/56 , A01N43/653 , C07D231/38 , C07D233/64 , C07D233/68 , C07D233/84 , C07D233/88 , C07D233/90 , C07D401/04 , C07D401/12 , C07D403/06 , C07D403/10 , C07D405/06 , C07D405/04 , C07D249/06 , C07D231/14 , A01N55/00 , A61K31/695 , A61K31/4192 , A61K31/4439 , A61K31/415 , A61K31/4178 , A61K31/4196 , C07F7/10 , C07D249/08 , C07D231/16 , C07D231/18 , C07D403/04 , A61K31/4164 , A01N43/647
CPC分类号： C07D231/12 , A01N43/50 , A01N43/56 , A01N43/647 , A01N43/653 , A01N55/00 , A61K31/415 , A61K31/4164 , A61K31/4178 , A61K31/4192 , A61K31/4196 , A61K31/4439 , A61K31/695 , C07D231/14 , C07D231/16 , C07D231/18 , C07D231/38 , C07D233/64 , C07D233/68 , C07D233/84 , C07D233/88 , C07D233/90 , C07D249/06 , C07D249/08 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/10 , C07D403/12 , C07D405/04 , C07D405/06 , C07F7/10
摘要： A compound represented by Formula (I), or a salt or N-oxide compound thereof is provided.
In Formula (I), A1 to A4 each independently represents a carbon atom or nitrogen atom, X1 represents a C1-6 alkyl group or the like, n represents the number of X1 groups, R1 represents a C1-6 alkylthio group or the like, and D is a group represented by Formula (D-1) or (D-2), and
in Formula (D-1) and (D-2), * represents a binding position, Q represents a C1-6 alkyl group or the like, B1 and B2 each independently represents a nitrogen atom or the like, R2 represents a C1-6 alkyl group or the like that is bound to one of the nitrogen atoms in Formula (D-1), B3 and B4 each independently represents a nitrogen atom or carbon atom, R4 represents a C1-6 alkyl group or the like, and m represents the number of R4 groups.-
3.发明申请公开(公告)号：US20190216089A1
公开(公告)日：2019-07-18
申请号：US16312770
申请日：2017-05-18
发明人： XUEGANG PENG , TAO JIN , JINGYUAN ZHANG
CPC分类号： A01N57/20 , A01N43/56 , C07D231/18 , C07D231/20
摘要： The present invention relates to a compounded herbicidal composition containing Shuangzuocaotong and a method of using the same. The compounded herbicidal composition comprises an active ingredient A and an active ingredient B, wherein the active ingredient A is Shuangzuocaotong, and the active ingredient B is glyphosate or glufosinate ammonium, and the two active ingredients are present in a weight ratio of 1:100-1, preferably 1:60-1. The compounded herbicidal composition has synergistic effect and excellent activity to control resistant weeds.
-
公开(公告)号：US20190152940A1
公开(公告)日：2019-05-23
申请号：US16191199
申请日：2018-11-14
发明人： Ryan C. Clark , Yen Truong , Nicholas Stock , Jason Jacintho
IPC分类号： C07D333/26 , A61K45/06 , C07D213/81 , C07D231/18
CPC分类号： C07D333/26 , A61K45/06 , C07D213/81 , C07D231/18
摘要： The present invention includes a method of inhibiting, suppressing or preventing HBV infection in an individual in need thereof, comprising administering to the individual a therapeutically effective amount of at least one compound of the invention.
-
公开(公告)号：US09969684B2
公开(公告)日：2018-05-15
申请号：US15640342
申请日：2017-06-30
发明人： John P. Toscano , Frederick Arthur Brookfield , Andrew D. Cohen , Stephen Martin Courtney , Lisa Marie Frost , Vincent Jacob Kalish
IPC分类号： C07C311/48 , C07C317/00 , C07C323/00 , C07D213/00 , A61K31/00 , C07D213/74 , C07D261/10 , C07D263/58 , C07D285/125 , C07D295/096 , C07D307/82 , C07D333/62 , C07C317/14 , C07C323/67 , C07D309/12 , C07D317/14 , C07D231/18 , C07D333/34
CPC分类号： C07C311/48 , C07C317/14 , C07C323/67 , C07D213/74 , C07D231/18 , C07D261/10 , C07D263/58 , C07D285/125 , C07D295/096 , C07D307/82 , C07D309/12 , C07D317/14 , C07D333/34 , C07D333/62
摘要： The invention relates to N-hydroxysulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemia/reperfusion injury. Novel N-hydroxysulfonamide derivatives release NHO at a controlled rate under physiological conditions, and the rate of HNO release is modulated by varying the nature and location of functional groups on the N-hydroxysulfonamide derivatives.
-
公开(公告)号：US20180127368A1
公开(公告)日：2018-05-10
申请号：US15806554
申请日：2017-11-08
发明人： David Marcoux , Myra Beaudoin Bertrand , T.G. Murali Dhar , Michael G. Yang , Zili Xiao , Hai-Yun Xiao , Yeheng Zhu , Carolyn A. Weigelt , Douglas G Batt
IPC分类号： C07D211/48 , C07D213/40 , C07D295/195 , C07D213/75 , C07D333/48 , C07C317/44 , C07D335/02 , C07D471/04 , C07D307/22 , C07D241/08 , C07D207/10 , C07D207/16 , C07D231/08 , C07D309/10 , C07D211/96 , C07D471/10 , C07D205/04 , C07D207/277 , C07D257/04 , C07D205/08 , A61P37/00
CPC分类号： C07D211/48 , A61P37/00 , C07B2200/05 , C07B2200/07 , C07C317/20 , C07C317/24 , C07C317/30 , C07C317/44 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2602/38 , C07C2602/44 , C07C2602/50 , C07C2603/08 , C07C2603/12 , C07C2603/16 , C07C2603/90 , C07D205/04 , C07D205/08 , C07D207/09 , C07D207/10 , C07D207/16 , C07D207/277 , C07D207/28 , C07D211/62 , C07D211/78 , C07D211/96 , C07D213/40 , C07D213/56 , C07D213/75 , C07D213/81 , C07D215/36 , C07D231/06 , C07D231/08 , C07D231/18 , C07D233/64 , C07D233/76 , C07D233/78 , C07D233/90 , C07D241/08 , C07D249/12 , C07D257/04 , C07D261/18 , C07D263/20 , C07D285/06 , C07D295/16 , C07D295/195 , C07D305/08 , C07D307/22 , C07D309/10 , C07D333/48 , C07D335/02 , C07D401/04 , C07D401/12 , C07D405/04 , C07D405/12 , C07D471/04 , C07D471/10 , C07F9/091
摘要： There are described RORγ modulators of the formula (I), or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof, wherein all substituents are defined herein. Also provided are pharmaceutical compositions comprising the same. Such compounds and compositions are useful in methods for modulating RORγ activity in a cell and methods for treating a subject suffering from a disease or disorder in which the subject would therapeutically benefit from modulation of RORγ activity, for example, autoimmune and/or inflammatory disorders.
-
公开(公告)号：US20180118696A1
公开(公告)日：2018-05-03
申请号：US15696713
申请日：2017-09-06
IPC分类号： C07D249/04 , C07D249/10 , C07D231/14 , C07D261/18 , C07D263/34 , C07D263/38 , C07D271/07 , C07D239/28 , C07D231/20 , C07D275/03 , C07D471/04 , C07D403/12 , C07D213/81
CPC分类号： C07D249/04 , A61K31/415 , A61K31/4192 , A61K31/4196 , A61K31/42 , A61K31/421 , A61K31/4245 , A61K31/425 , A61K31/437 , A61K31/44 , A61K31/4985 , A61K31/505 , A61K45/06 , A61P9/04 , A61P9/12 , A61P13/12 , C07C229/34 , C07C271/22 , C07D213/81 , C07D231/14 , C07D231/18 , C07D231/20 , C07D233/70 , C07D233/90 , C07D235/08 , C07D237/14 , C07D239/28 , C07D239/34 , C07D249/10 , C07D249/12 , C07D249/18 , C07D261/12 , C07D261/18 , C07D263/18 , C07D263/34 , C07D263/38 , C07D271/07 , C07D275/03 , C07D295/10 , C07D309/40 , C07D319/06 , C07D401/04 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/12 , C07D405/14 , C07D471/04
摘要： In one aspect, the invention relates to compounds having the formula I: where R1-R6 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising these compounds; methods of using these compounds; and processes and intermediates for preparing these compounds.
-
公开(公告)号：US20180044282A1
公开(公告)日：2018-02-15
申请号：US15688732
申请日：2017-08-28
发明人： Kenneth W. Bair , Nicholas Barczak , Bingsong Han , David R. Lancia, JR. , Cuixian Liu , Matthew W. Martin , Pui Yee Ng , Aleksandra Rudnitskaya , Jennifer R. Thomason , Mary Margaret Zablocki , Xiaozhang Zheng
IPC分类号： C07C259/06 , C07D471/04 , C07D417/04 , C07D241/08 , C07D213/56 , C07D233/68 , C07D235/14 , C07D487/10 , C07D471/10 , C07D295/155 , C07D209/44 , A61K31/5377 , A61K31/4439 , A61K31/495 , A61K31/44 , A61K31/417 , A61K31/4184 , A61K31/397 , C07D495/10 , A61K31/407 , A61K31/435 , A61K31/451 , A61K31/4035 , A61K31/277 , A61K31/438 , C07D221/20 , A61K31/185 , C07D307/68 , C07D213/65 , C07D295/192 , C07D211/58 , C07D211/16 , C07D513/10 , C07D209/46 , C07D209/42 , C07D277/56 , C07D209/08 , C07D498/04 , C07D207/267 , C07D493/08 , C07D207/10 , C07D491/10 , C07D487/08 , C07D487/04 , C07D261/18 , C07D257/04 , C07D249/18 , C07D417/12 , C07D241/12 , C07D409/12 , C07D409/04 , C07D405/12 , C07D239/22 , C07D239/20 , C07D235/30 , C07D401/12 , C07D401/04 , C07D333/70 , C07D233/38 , C07D233/36 , C07D231/18 , C07D231/14 , C07D317/68 , C07D215/12 , C07D213/81 , C07D213/75 , C07D401/14
CPC分类号： C07C259/06 , A61K31/185 , A61K31/277 , A61K31/397 , A61K31/4035 , A61K31/407 , A61K31/417 , A61K31/4184 , A61K31/435 , A61K31/438 , A61K31/44 , A61K31/4439 , A61K31/451 , A61K31/495 , A61K31/5377 , C07D207/10 , C07D207/267 , C07D209/08 , C07D209/42 , C07D209/44 , C07D209/46 , C07D211/16 , C07D211/58 , C07D213/56 , C07D213/65 , C07D213/75 , C07D213/81 , C07D215/12 , C07D221/20 , C07D231/14 , C07D231/18 , C07D233/36 , C07D233/38 , C07D233/68 , C07D235/14 , C07D235/30 , C07D239/20 , C07D239/22 , C07D241/08 , C07D241/12 , C07D249/18 , C07D257/04 , C07D261/18 , C07D277/56 , C07D295/155 , C07D295/192 , C07D307/68 , C07D317/68 , C07D333/70 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/04 , C07D409/12 , C07D417/04 , C07D417/12 , C07D471/04 , C07D471/10 , C07D487/04 , C07D487/08 , C07D487/10 , C07D491/10 , C07D493/08 , C07D495/10 , C07D498/04 , C07D513/10 , Y02A50/393 , Y02A50/411 , Y02A50/481
摘要： The present invention relates to inhibitors of histone deacetylases, in particular HDAC8, that are useful for the treatment of cancer and other diseases and disorders, as well as the synthesis and applications of said inhibitors.
-
公开(公告)号：US20180016199A1
公开(公告)日：2018-01-18
申请号：US15548561
申请日：2016-02-05
申请人： BASF SE
发明人： Barbara Nave , Joachim Dickhaut , Peter Nesvadba , Mihiret Tekeste Sisay , Alexander Wissemeier , Wolfram Zerulla , Gregor Pasda , Olof Wallquist , Allan F Cunningham
IPC分类号： C05G3/08 , C07D403/12 , C07D401/04 , C05C3/00 , C07D231/54 , C07D231/12 , C07D471/04 , C07D403/04
CPC分类号： C05G3/08 , A01N43/56 , A01N43/58 , C05C3/00 , C07D231/12 , C07D231/14 , C07D231/18 , C07D231/20 , C07D231/54 , C07D231/56 , C07D401/04 , C07D403/04 , C07D403/12 , C07D471/04 , Y02P60/218
摘要： Pyrazole derivatives as nitrification inhibitors are described herein.
-
10.发明申请公开(公告)号：US20170368029A1
公开(公告)日：2017-12-28
申请号：US15539061
申请日：2015-12-18
申请人： Nektar Therapeutics
IPC分类号： A61K31/4025 , C07D231/18 , C07D207/04 , C07D213/71 , C07D333/34 , C07D261/10
CPC分类号： A61K31/4025 , C07D207/04 , C07D207/12 , C07D207/14 , C07D213/71 , C07D231/18 , C07D239/60 , C07D261/10 , C07D295/13 , C07D295/135 , C07D333/34
摘要： Compounds and pharmaceutically acceptable salts and solvates thereof are described. The compounds relate to and/or have application(s) in (among others) the fields of drug discovery, pharmacotherapy, physiology and organic chemistry.
-
-
-
-
-
-
-
-
-
搜索结果
691 条记录 (耗时 0.045 秒)
