摘要:
The present invention relates to a method of treating an inflammatory disorder in a subject with an effective amount of compound having the general formula (I) as described in the present application, under conditions effective to treat the inflammatory disorder. The present invention also relates to a method of inhibiting respiratory burst in neutrophils without inhibiting degranulation in or bacterial killing by the neutrophils by contacting neutrophils with the compounds described above.
摘要:
The present invention relates to a method of treating an inflammatory disorder in a subject with an effective amount of compound having the general formula (I) as described in the present application, under conditions effective to treat the inflammatory disorder. The present invention also relates to a method of inhibiting respiratory burst in neutrophils without or inhibiting degranulation in or bacterial killing by the neutrophils by contacting neutrophils with the compounds described above.
摘要:
The present invention relates to proteasome inhibitors and their use in methods of treating a subject for a pathogen infection or cancer. The methods involve administering to the subject a compound of Formula (I). (I) where: Q is Formula or Formula, where the crossing dashed line illustrates the bond formed joining Q to the rest of the compound of Formula (I). The remainder of substituents of the compound of Formula (I) are defined in the present application.
摘要:
The invention relates to aminopyrimidine compounds useful for treating diseases mediated by polo-like kinase 1 (Plk1). The invention also relates to the therapeutic use of such aminopyrimidine compounds and compositions thereof in treating disease states associated with abnormal cell growth and unwanted cell proliferation.
摘要:
Solid state gas sensors are provided, the use of which permits quantitative measurement of gaseous contaminants or change of composition of a gas or atmosphere being monitored. The gas sensor comprises at least a base, a first electrode, a second electrode. The first electrode has a finely tapered end to strengthen the electric field intensity in the gap between the first and the second electrodes. The sensing is based on ionization potential difference between the molecules of the contaminating gas and of the atmosphere. When a high voltage is applied to the electrodes, it creates a strong electric field between the electrodes, especially a very strong electric field around the tapered end of the first electrode. When the potential is sufficiently high, the gas in the vicinity of the tapered end of the first electrode will be ionized. The ions and electrons generated by the ionization create an electric current flows between the two electrodes and across the gap. The changes of this electric current with gas contamination or changes in the gas composition are used as sensing signals. Unlike other gas sensors, there is no chemical reaction, absorption or adsorption involved in this sensing process. The gas sensors of this invention may be manufactured by lithographic micromachining techniques at very low cost, and they can be easily integrated with controller and signal processing circuits to upgrade to smart microsensors. Further, in an alternative embodiment, a micro-actuator to control the gap between the two electrodes is integrated with the sensors. In another alternative embodiment, a third electrode may be mounted so as to control the intensity of the electric field.
摘要:
A power module mounted on a system board comprises a printed circuit board having an extension part, at least one primary winding coil disposed on a first side of the extension part. The at least one primary winding coil is disposed at a primary side of the power module. The power module further comprises a PCB winding formed on the extension part at a secondary side of the power module, a first magnetic core assembly, and a connector. The first magnetic core assembly comprises a first magnetic part and a second magnetic part. The at least one primary winding coil and the extension part are enclosed between the first magnetic part and the second magnetic part.
摘要:
The tripeptide Tyrosyl-seryl-valine is disclosed with its use as a pharmaceutical composition. A method is also disclosed making a pharmaceutical composition comprising providing the tripeptide Tyrosyl-seryl-valine and mixing said tripeptide with a pharmaceutical acceptable carrier.
摘要:
An apparatus and method for testing a component of a magnetic disk drive in which one or more drive-based components is used in the testing process. Each of the drive-based components is based on a corresponding one of the components of the magnetic disk drive. During testing, the component to be tested and at least one of the drive-based components are selectively engaged.
摘要:
A hard drive component test system is provided. The hard drive component test system includes a rack having multiple test bays with first test sub-assemblies mounted in respective ones of the of test bays. A test control system is electrically coupled to each of the first test sub-assemblies. Each of the test bays is configured to receive a second test sub-assembly and to engage the second test sub-assembly with the first test sub-assembly mounted in the respective bay to form a drive assembly. The test control system is configured to selectively execute a test process on the drive assemblies mounted in the rack.
摘要:
Various embodiments of systems and methods for performing volume-based incremental backups are disclosed. A method may involve generating a snappoint of a volume. The snappoint indicates which portions (e.g., blocks or extents) of the volume have been modified between a time at which the snappoint was generated and a time at which a subsequent snappoint was generated. The method may also involve accessing information mapping the file to the volume and, if the snappoint identifies as having been modified any blocks of the volume to which the file maps, copying those blocks from the subsequent snappoint to the backup device. Portions not identified as having been modified by the snappoint are not copied. Program instructions implementing such a method may be stored on a computer accessible medium.