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    COAXIAL ELECTROSPUN FIBERS AND STRUCTURES AND METHODS OF FORMING THE SAME
    1.
    发明申请
    COAXIAL ELECTROSPUN FIBERS AND STRUCTURES AND METHODS OF FORMING THE SAME 审中-公开
    同轴电纺纤维及其结构及其形成方法

    公开(公告)号：US20100055154A1

    公开(公告)日：2010-03-04

    申请号：US12373737

    申请日：2007-07-18

    申请人： I-Chien Liao ,  Kam W. Leong ,  Sing-Yian Chew

    发明人： I-Chien Liao ,  Kam W. Leong ,  Sing-Yian Chew

    IPC分类号： A61K9/70 ,  B29C47/02 ,  A61P43/00

    CPC分类号： A61K9/0092 ,  C12N15/88 ,  C12N2799/022 ,  D01D5/0038 ,  D01D5/247 ,  D01F1/10 ,  D01F8/14

    摘要： Nanofibers and microfibers having a core and a polymer shell surrounding the core are provided. The shell includes a plurality of channels that extend from an outer shell surface to the core, and one or more agents, such as pharmacological materials, proteins, viruses, plasmid DNA, bacterial cells, drug-loaded nanoparticles, are encapsulated within the core. The one or more agents discharge from the core through the channels at a controlled rate. The channels are formed by porogen material within the polymer shell.

    摘要翻译： 提供具有核心和包围核心的聚合物壳的纳米纤维和微纤维。 壳体包括从外壳表面延伸到核心的多个通道，并且将一种或多种试剂（例如药理学材料，蛋白质，病毒，质粒DNA，细菌细胞，载药纳米颗粒）包封在核心内。 一个或多个试剂以受控的速率通过通道从核心排出。 通道由聚合物壳内的致孔剂材料形成。