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公开(公告)号：US07951602B2
公开(公告)日：2011-05-31
申请号：US11845856
申请日：2007-08-28
IPC分类号： G01N33/48
CPC分类号： C07K1/13 , G01N33/6848 , Y10T436/24
摘要： Mass defect labeled peptides and methods of identifying peptides are provided. In particular, embodiments of the present disclosure include mass defect labels for polypeptides that include at least one cysteine and/or at least one tryptophan and methods of using the mass defect labels to identify polypeptides. One embodiment, among others, includes a mass defect labeled peptide including at least one cysteine residue labeled with 2,4-dibromo-acetanilide. Another embodiment, among others, includes a mass defect labeled peptide including at least one tryptophan residue labeled with 4,6-dibromo-2-trifluoromethylphenylsulfenyl chloride.
摘要翻译： 提供质量缺陷标记的肽和鉴定肽的方法。 特别地，本公开的实施方案包括用于包含至少一个半胱氨酸和/或至少一种色氨酸的多肽的质量缺陷标签，以及使用质量缺陷标记物鉴定多肽的方法。 一个实施方案包括质量缺陷标记的肽，其包括至少一个用2,4-二溴 - 乙酰苯胺标记的半胱氨酸残基。 另一个实施方案包括质量缺陷标记的肽，其包括用4,6-二溴-2-三氟甲基苯基硫基氯标记的至少一个色氨酸残基。
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公开(公告)号：US20090061523A1
公开(公告)日：2009-03-05
申请号：US11845856
申请日：2007-08-28
CPC分类号： C07K1/13 , G01N33/6848 , Y10T436/24
摘要： Briefly described, embodiments of this disclosure include mass defect labeled peptides, methods of identifying peptides, and the like.
摘要翻译： 简要描述，本公开的实施方案包括质量缺陷标记的肽，鉴定肽的方法等。
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公开(公告)号：US07700912B2
公开(公告)日：2010-04-20
申请号：US11807555
申请日：2007-05-29
IPC分类号： H01J49/00
CPC分类号： H01J49/0009
摘要： Briefly described, embodiments of this disclosure include methods of calibrating a mass spectrometry system, and the like. One exemplary method of calibrating a mass spectrometry system, among others, includes: acquiring a first mass spectrum of a sample using a first trapping potential, wherein the first mass spectrum is acquired from a low ion population, wherein the first mass spectrum includes a first set of mass ion values; and acquiring a second mass spectrum of the sample using a second trapping potential, wherein the second mass spectrum is acquired from a high ion population, wherein the second mass spectrum includes a second set of mass ion values, wherein the first trapping potential is lower than the second trapping potential, wherein the first set of mass ion values is more accurate than the second set of mass ion values, wherein the second set of ion values has a greater signal-to-noise value and a greater detection dynamic range than the first set of mass values, and wherein the first set of mass values is used to calibrate the second set of mass values.
摘要翻译： 简要描述，本公开的实施方案包括校准质谱系统的方法等。 一种校准质谱系统的示例性方法，其中包括：使用第一捕获电位获取样品的第一质谱，其中从低离子群体获取第一质谱，其中第一质谱包括第一质谱 一组质量离子值; 以及使用第二捕获电位获取所述样品的第二质谱，其中所述第二质谱从高离子群体获得，其中所述第二质谱包括第二组质量离子值，其中所述第一捕获电位低于 第二捕获电位，其中第一组质量离子值比第二组质量离子值更精确，其中第二组离子值具有比第一组离子值更大的信噪比和更大的检测动态范围 一组质量值，并且其中第一组质量值用于校准第二组质量值。
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公开(公告)号：US20080067346A1
公开(公告)日：2008-03-20
申请号：US11807555
申请日：2007-05-29
IPC分类号： B01D59/44
CPC分类号： H01J49/0009
摘要： Briefly described, embodiments of this disclosure include methods of calibrating a mass spectrometry system, and the like. One exemplary method of calibrating a mass spectrometry system, among others, includes: acquiring a first mass spectrum of a sample using a first trapping potential, wherein the first mass spectrum are acquired from a low ion population, wherein the first mass spectrum include a first set of mass ion values; and acquiring a second mass spectrum of the sample using a second trapping potential, wherein the second mass spectrum is acquired from a high ion population, wherein the second mass spectrum includes a second set of mass ion values, wherein the first trapping potential is lower than the second trapping potential, wherein the first set of mass ion values are more accurate than the second set of mass ion values, wherein the second set of ion values have a greater signal-to-noise value and a greater detection dynamic range than the first set of mass values, and wherein the first set of mass values are used to calibrate the second set of mass values.
摘要翻译： 简要描述，本公开的实施方案包括校准质谱系统的方法等。 一种校准质谱系统的示例性方法，其中包括：使用第一捕获电位获取样品的第一质谱，其中从低离子群体获取第一质谱，其中第一质谱包括第一质谱 一组质量离子值; 以及使用第二捕获电位获取所述样品的第二质谱，其中所述第二质谱从高离子群体获得，其中所述第二质谱包括第二组质量离子值，其中所述第一捕获电位低于 第二陷阱电位，其中第一组质量离子值比第二组质量离子值更精确，其中第二组离子值具有比第一组离子值更大的信噪比和更大的检测动态范围 一组质量值，并且其中第一组质量值用于校准第二组质量值。
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