公开(公告)号：US20160194268A1

公开(公告)日：2016-07-07

申请号：US14905645

申请日：2014-07-03

Applicant: IHARA CHEMICAL INDUSTRY CO., LTD.

Inventor： Shinki TAni ,  Minekazu Koga ,  Izumi Matsumoto

IPC: C07C67/313

CPC classification number: C07C67/313 ,  C07C67/31 ,  C07C69/716 ,  C07C69/675

Abstract: Provided is a method for producing an industrially useful ketomalonic acid compound such as ketomalinic acid diesters, or a hydrate thereof, by a method more favorable from an economic and environmental standpoint and from a safety standpoint. The present invention relates to a method involving reacting a malonic acid compound represented by general formula (1) (in the formula, The each Rs indicate an alkyl group, a cycloalkyl group, etc.) with chlorine dioxide to produce a ketomalonic acid compound represented by the general formula (2) (in the formula, R has the same meaning as above), or a hydrate thereof.

Abstract translation: 本发明提供从经济和环境的观点出发，从安全性的观点出发，通过更有利的方法制造工业上有用的酮咯酸化合物如酮三酸二酯或其水合物的方法。 本发明涉及使通式（1）表示的丙二酸化合物（式中，各Rs表示烷基，环烷基等）与二氧化氯反应，制备代表性的酮咯酸化合物 通式（2）（式中，R与上述相同）或其水合物。

公开(公告)号：US09499469B2

公开(公告)日：2016-11-22

申请号：US14905645

申请日：2014-07-03

Applicant: IHARA CHEMICAL INDUSTRY CO., LTD.

Inventor： Shinki Tani ,  Minekazu Koga ,  Izumi Matsumoto

IPC: C07C69/66 ,  C07C67/313

CPC classification number: C07C67/313 ,  C07C67/31 ,  C07C69/716 ,  C07C69/675

Abstract: Provided is a method for producing an industrially useful ketomalonic acid compound such as ketomalinic acid diesters, or a hydrate thereof, by a method more favorable from an economic and environmental standpoint and from a safety standpoint. The present invention relates to a method involving reacting a malonic acid compound represented by general formula (1) (in the formula, The each Rs indicate an alkyl group, a cycloalkyl group, etc.) with chlorine dioxide to produce a ketomalonic acid compound represented by the general formula (2) (in the formula, R has the same meaning as above), or a hydrate thereof.