公开(公告)号：US20220204449A1

公开(公告)日：2022-06-30

申请号：US17548288

申请日：2021-12-10

申请人： ILDONG PHARMACEUTICAL CO., LTD.

发明人： Woojin JEON ,  Do Sup LEE ,  Suh-Youn SHON ,  Junsu BAN ,  Sungjun HONG ,  Jin Hee LEE ,  Jaeho HEO ,  Jungwoo LEE ,  JoonTae PARK ,  Kyung Mi AN ,  Hongchul YOON

IPC分类号： C07D209/08 ,  C07D307/79 ,  C07D319/18

摘要： The present disclosure provides pharmaceutical compositions and compounds having dual agonist activity at the μ and δ opioid receptors. The agonist compounds of this disclosure can also provide GPCR functional selectivity, including selective activity in the Gi pathway. In some embodiments, the compounds of this disclosure are biased μ-opioid and/or δ-opioid receptor agonists that do not significantly recruit β-arrestins, but can activate G-protein-dependent pathways, and thus can be administered without risk of significant undesirable side effects exhibited by conventional opioid receptor agonists. In some embodiments there is provided a substantially optically pure compound having dual agonist activity at the μ and δ opioid receptors.