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公开(公告)号：US20230373954A1
公开(公告)日：2023-11-23
申请号：US18228672
申请日：2023-08-01
发明人： Hong Chul Yoon , Joon Tae Park , Jung Woo Lee , Kyung Mi An , A Rang IM , Woo Jin Jeon , Jae Ho Heo , Chang Hee Hong , Jung Eun Park , Te Ik Sohn , Da Hae Hong , Jung Ho Kim , Jae Eui Shin , Yeong Ran Yoo , Min Whan Chang , In Gyu Je , Su Yeon Kang , Yoon Sung Song , Joo Yun Lee
IPC分类号： C07D401/12 , A61P29/00 , A61P1/04
CPC分类号： C07D401/12 , A61P29/00 , A61P1/04
摘要： The present invention provides a novel compound represented by Chemical Formula 2, or a pharmaceutically acceptable salt thereof. The novel compound according to the present invention exhibits an excellent acid secretion inhibitory effect.
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![Substituted pyrazolo[4,3-d]pyrimidines and imidazo[5,1 -f][1,2,4]triazines as androgen receptor and phosphodiesterase dual inhibitors](/abs-image/US/2023/10/17/US11787812B2/abs.jpg.150x150.jpg)
公开(公告)号：US11787812B2
公开(公告)日：2023-10-17
申请号：US17548279
申请日：2021-12-10
发明人： Yoonsuk Lee , Kyung Sun Kim , Jeong-Ah Kim , Anna Moon , Dongkeun Song , Juyoung Jung , Jun-Su Ban , Soo-Jin Lee
IPC分类号： A61K31/519 , A61K31/53 , C07D239/70 , C07D253/08 , C07D487/04 , G01N33/50 , C07D519/00
CPC分类号： C07D487/04 , C07D519/00 , G01N33/5041
摘要： The present disclosure provides androgen receptor (AR) and phosphodiesterase 5 (PDE-5) inhibitor compounds of the formula (I):
and compositions including said compounds. The compounds can provide dual functionality for inhibiting AR and inhibiting PDE-5. The present disclosure also provides methods of using said compounds and compositions for inhibiting AR and PDE-5 in a biological system or biological sample. Also provided are methods of preparing said compounds and compositions, and synthetic precursors of said compounds.-
公开(公告)号：US20230320991A1
公开(公告)日：2023-10-12
申请号：US18332726
申请日：2023-06-10
发明人： Young-Hoo KIM , Hyeong-Eun KIM , Chi-Young HAN , Han Sol SEO , Tae-Yoon KIM , Sunghee LEE
IPC分类号： A61K9/50 , A23L33/135 , A61K35/741 , A61K9/19
CPC分类号： A61K9/5036 , A23L33/135 , A61K35/741 , A61K9/19
摘要： Disclosed is a process for non-stop production of encapsulated probiotics, in which an alginate hydrogel is spontaneously formed through a simple process of culturing probiotics in a medium containing an alginate, a salt that forms a hydrogel by binding to alginic acid, preferably an insoluble carbonate, and optionally an encapsulation enhancer, and probiotics are encapsulated by the alginate hydrogel, thereby not only greatly improving the probiotic encapsulation process but also remarkably improving the freeze-drying viability, heat tolerance, shelf stability, and in-vivo stability (acid resistance and bile resistance) of probiotics.
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公开(公告)号：US20230192650A1
公开(公告)日：2023-06-22
申请号：US18011084
申请日：2021-06-16
发明人： Hong Chul Yoon , Joon Tae Park , Jung Woo Lee , Kyung Mi An , Rang A IM , Woo Jin Jeon , Jae Ho Heo , Chang Hee Hong , Jung Eun Park , Te Ik Sohn , Da Hae Hong , Jung Ho Kim , Jae Eui Shin , Yeong Ran Yoo , Min Whan Chang , In Gyu Je , Su Yeon Kang , Yoon Sung Song , Joo Yun Lee
IPC分类号： C07D401/12 , A61P29/00 , A61P1/04
CPC分类号： C07D401/12 , A61P29/00 , A61P1/04
摘要： The present invention provides a novel compound represented by Chemical Formula 2, or a pharmaceutically acceptable salt thereof. The novel compound according to the present invention exhibits an excellent acid secretion inhibitory effect.
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公开(公告)号：US20220194948A1
公开(公告)日：2022-06-23
申请号：US17548279
申请日：2021-12-10
发明人： Yoonsuk LEE , Kyung Sun KIM , Jeong-Ah KIM , Anna MOON , Dongkeun SONG , Juyoung JUNG , Jun-Su BAN , Soo-Jin LEE
IPC分类号： C07D487/04 , G01N33/50 , C07D519/00
摘要： The present disclosure provides androgen receptor (AR) and phosphodiesterase 5 (PDE-5) inhibitor compounds and compositions including said compounds. The compounds can provide dual functionality for inhibiting AR and inhibiting PDE-5. The present disclosure also provides methods of using said compounds and compositions for inhibiting AR and PDE-5 in a biological system or sample. Also provided are methods of preparing said compounds and compositions, and synthetic precursors of said compounds.
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公开(公告)号：US10894086B2
公开(公告)日：2021-01-19
申请号：US15760166
申请日：2016-09-19
发明人： Seung-Hun Lee , Dae Jung Kang , Jae-Hoon Kang
IPC分类号： A61K35/744 , A61K35/745 , A61K35/747 , A61K35/74 , A61K47/36 , A61K47/10 , A61K47/14 , A61K47/32 , A61K47/38 , A61K47/42 , A61K9/50 , C12N1/20 , C08B37/08 , C08L5/08 , C08L5/00 , C08L89/00 , C08L93/00 , C09D105/08 , A23L33/135 , A23L5/00 , A61P1/00 , A61P1/14 , C07K14/47 , C07K14/415
摘要： The present invention relates to a functional hydrated hyaluronic acid and a method for producing 5th generation coated lactic acid bacteria having excellent intestinal mucoadhesive ability and a selective antagonism using the same and, more specifically, to a functional hydrated hyaluronic acid in which components fermented by lactic acid bacteria are captured in hyaluronic acid, which is a natural polymer substance, and a method for producing coated lactic acid bacteria using the same. The quadruply coated lactic acid bacteria coated using the functional hydrated hyaluronic acid according to the present invention is quadruply coated with a water-soluble polymer, a functional hydrated hyaluronic acid, a coating agent having porous particles, and a protein, thereby producing an excellent intestinal mucoadhesive ability, exhibiting an antibacterial action against deleterious bacteria in the intestines, and promoting growth of beneficial bacteria in the intestines.
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公开(公告)号：US20180250412A1
公开(公告)日：2018-09-06
申请号：US15760166
申请日：2016-09-19
发明人： Seung-Hun LEE , Dae Jung KANG , Jae-Hoon KANG
IPC分类号： A61K47/36 , C12N1/20 , A61K35/747 , A61K35/745 , A61K35/744 , C08L5/08 , C09D105/08
CPC分类号： A61K47/36 , A61K35/74 , A61K35/744 , A61K35/745 , A61K35/747 , C08L5/08 , C08L2203/02 , C09D105/08 , C12N1/20
摘要： The present invention relates to a functional hydrated hyaluronic acid and a method for producing 5th generation coated lactic acid bacteria having excellent intestinal mucoadhesive ability and a selective antagonism using the same and, more specifically, to a functional hydrated hyaluronic acid in which components fermented by lactic acid bacteria are captured in hyaluronic acid, which is a natural polymer substance, and a method for producing coated lactic acid bacteria using the same. The quadruply coated lactic acid bacteria coated using the functional hydrated hyaluronic acid according to the present invention is quadruply coated with a water-soluble polymer, a functional hydrated hyaluronic acid, a coating agent having porous particles, and a protein, thereby producing an excellent intestinal mucoadhesive ability, exhibiting an antibacterial action against deleterious bacteria in the intestines, and promoting growth of beneficial bacteria in the intestines.
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公开(公告)号：US11912674B2
公开(公告)日：2024-02-27
申请号：US17191806
申请日：2021-03-04
发明人： Jae-Hoon Kang , Hong-Sub Lee , Yoon-Suk Lee , Jin-Ah Jeong , Sung-Wook Kwon , Jeong-Guen Kim , Kyung-Sun Kim , Dong-Keun Song , Sun-Young Park , Kyeo-Jin Kim , Ji-Hye Choi , Hey-Min Hwang
IPC分类号： C07D261/08
CPC分类号： C07D261/08
摘要： The present invention provides methods for treating or ameliorating metabolic diseases, cholestatic liver diseases, or organ fibrosis, which comprises administering to a subject a therapeutically effective amount of a pharmaceutical composition comprising an isoxazole derivative, a racemate, an enantiomer, or a diastereoisomer thereof, or a pharmaceutically acceptable salt of the derivative, the racemate, the enantiomer, or the diastereoisomer.
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公开(公告)号：US20230212140A1
公开(公告)日：2023-07-06
申请号：US18120876
申请日：2023-03-13
发明人： Hong Chul Yoon , Kyung Mi , myong Jae Lee , Jin Hee Lee , Jeong-Geun Kim , A-rang Im , Woo Jin Jeon , Jin Ah Jeong , Jaeho Heo , Changhee Hong , Kyeojin Kim , Jung-Eun Park , Te-ik Sohn , Changmok Oh , Da Hae Hong , Sung Wook Kwon , Jung Ho Kim , Jae Eui Shin , Yeongran Yoo , Min Whan Chang , Eun Hye Jang , In-gyu Je , Ji Hye Choi , Gunhee Kim , Yearin Jun
IPC分类号： A61K31/496 , A61K31/4545 , A61K31/497 , A61P3/10
CPC分类号： A61K31/496 , A61K31/4545 , A61K31/497 , A61P3/10
摘要： Disclosed are novel compounds of Chemical Formula 1, optical isomers of the compounds, and pharmaceutically acceptable salts of the compounds or the optical isomers. The compounds, isomers, and salts exhibit excellent activity as GLP-1 receptor agonists. In particular, they, as GLP-1 receptor agonists, exhibit excellent glucose tolerance, thus having a great potential to be used as therapeutic agents for metabolic diseases. Moreover, they exhibit excellent pharmacological safety for cardiovascular systems.
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公开(公告)号：US11643403B2
公开(公告)日：2023-05-09
申请号：US17777193
申请日：2020-11-13
发明人： Hong Chul Yoon , Kyung Mi An , Myong Jae Lee , Jin Hee Lee , Jeong-geun Kim , A-rang Im , Woo Jin Jeon , Jin Ah Jeong , Jaeho Heo , Changhee Hong , Kyeojin Kim , Jung-eun Park , Te-ik Sohn , Changmok Oh , Da Hae Hong , Sung Wook Kwon , Jung Ho Kim , Jae Eui Shin , Yeongran Yoo , Min Whan Chang , Eun Hye Jang , In-Gyu Je , Ji Hye Choi , Gunhee Kim , Yearin Jun
IPC分类号： C07D471/04 , A61P3/10 , C07D405/14 , C07D235/14 , C07D413/14
CPC分类号： C07D405/14 , A61P3/10 , C07D235/14 , C07D413/14 , C07D471/04
摘要： Disclosed are novel compounds of Chemical Formula 1, optical isomers of the compounds, and pharmaceutically acceptable salts of the compounds or the optical isomers. The compounds, isomers, and salts exhibit excellent activity as GLP-1 receptor agonists. In particular, they, as GLP-1 receptor agonists, exhibit excellent glucose tolerance, thus having a great potential to be used as therapeutic agents for metabolic diseases. Moreover, they exhibit excellent pharmacological safety for cardiovascular systems.
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