公开(公告)号：US12031181B2

公开(公告)日：2024-07-09

申请号：US16838832

申请日：2020-04-02

Applicant: ILLUMINA, INC.

Inventor： Bochao Zhang ,  Shile Zhang

IPC: C12Q1/6881 ,  A61B5/00 ,  G16B20/20 ,  G16B20/40 ,  G16H20/40 ,  G16H50/30

CPC classification number: C12Q1/6881 ,  A61B5/444 ,  G16B20/20 ,  G16B20/40 ,  G16H20/40 ,  G16H50/30

Abstract: Provided herein are systems and methods for quantitating the HLA diversity in a solid tissue or circulating tumor DNA sample that is predictive of a patient's responsiveness to immune checkpoint inhibitory therapies.