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    Sequencing instrument
    7.
    外观设计
    Sequencing instrument 有权

    公开(公告)号：USD1042875S1

    公开(公告)日：2024-09-17

    申请号：US29865262

    申请日：2022-07-15

    申请人： Illumina, Inc. ,  Illumina Singapore Pte. Ltd.

    设计人： Erik Allegoren ,  Jack Godfrey Wood ,  Ridwan Liow ,  Max Warren Pollock ,  Robert Nicholas Dean

    摘要： FIG. 1 is a front, right top perspective view of a sequencing instrument illustrating our new design;
    FIG. 2 is a front, right bottom perspective view of the design of FIG. 1;
    FIG. 3 is a front, left top perspective view of the design of FIG. 1;
    FIG. 4 is a front, left bottom perspective view of the design of FIG. 1;
    FIG. 5 is an enlarged partial, front, right top perspective view of the design of FIG. 1;
    FIG. 6 is an enlarged partial, front, left top perspective view of the design of FIG. 1;
    FIG. 7 is an enlarged partial, front, right bottom perspective view of the design of FIG. 1;
    FIG. 8 is an enlarged partial, front, left bottom perspective view of the design of FIG. 1;
    FIG. 9 is an enlarged partial, front, top perspective view of the design of FIG. 1;
    FIG. 10 is an enlarged partial, front, bottom perspective view of the design of FIG. 1;
    FIG. 11 is a rear, left top perspective view of the design of FIG. 1;
    FIG. 12 is a rear, left below perspective view of the design of FIG. 1;
    FIG. 13 is a rear, right top perspective view of the design of FIG. 1;
    FIG. 14 is a rear, right bottom perspective view of the design of FIG. 1;
    FIG. 15 is a front elevational view of the design of FIG. 1;
    FIG. 16 is a right side elevational view of the design of FIG. 1;
    FIG. 17 is a left side elevational view of the design of FIG. 1;
    FIG. 18 is a rear elevational view of the design of FIG. 1;
    FIG. 19 is a top plan view of the design of FIG. 1; and,
    FIG. 20 is a bottom plan view of the design of FIG. 1.
    The even length broken lines shown in the drawings illustrate portions of the sequencing instrument that form no part of the claimed design. The dot-dash cutaway lines shown in FIGS. 5 through 10 represent the boundaries of the enlarged views and form no part of the claimed design.
    The dash-dot lines in the drawings represent a boundary of the claimed design.

    Quality score compression
    9.
    发明授权
    Quality score compression 有权

    公开(公告)号：US12080385B2

    公开(公告)日：2024-09-03

    申请号：US18237187

    申请日：2023-08-23

    申请人： Illumina, Inc.

    发明人： Guillaume Alexandre Pascal Rizk

    IPC分类号： H03M7/00 ,  G16B50/50 ,  H03M7/30

    CPC分类号： G16B50/50 ,  H03M7/3071 ,  H03M7/6011

    摘要： Methods, systems, and computer programs for compressing nucleic acid sequence data. A method can include obtaining nucleic acid sequence data representing: (i) a read sequence, and (ii) a plurality of quality scores, determining whether the read sequence includes at least one “N” base, based on a determination that the read sequence includes at least one “N” base, generating, by one or more computers, a first encoding data set by using a first encoding process to encode each set of four quality scores of the read sequence into a single byte of memory, and using a second encoding process to encode the first encoded data set, thereby compressing the data to be compressed.

    GENOMIC LIBRARY PREPARATION AND TARGETED EPIGENETIC ASSAYS USING CAS-GRNA RIBONUCLEOPROTEINS
    10.
    发明公开
    GENOMIC LIBRARY PREPARATION AND TARGETED EPIGENETIC ASSAYS USING CAS-GRNA RIBONUCLEOPROTEINS 审中-公开

    公开(公告)号：US20240287504A1

    公开(公告)日：2024-08-29

    申请号：US18549344

    申请日：2022-03-08

    申请人： Illumina, Inc. ,  Illumina Cambridge Limited

    发明人： Andrew Kennedy ,  Sarah Shultzaberger ,  Emma Bell ,  Oliver Miller ,  Kim Schneider ,  Esther Musgrave-Brown ,  Niall Gormley ,  Andrew Slatter ,  Feng Chen

    IPC分类号： C12N15/10

    CPC分类号： C12N15/1065

    摘要： Genomic library preparation using Cas-gRNA RNPs, and targeted epigenetic assays, are provided herein. Some compositions include, from a first species, substantially only single-stranded polynucleotides; from a second species, substantially only double-stranded polynucleotides; and amplification primers ligated to ends of the second double-stranded polynucleotides and substantially not ligated to any ends of the first double-stranded polynucleotides. Some compositions include first and second molecules of a target polynucleotide having a sequence, the first molecule having a first end at a first subsequence, the second molecule having a first end at a second subsequence, wherein the first subsequence only partially overlaps with the second subsequence. Some examples provide a composition that includes a target polynucleotide and a first fusion protein including a Cas-gRNA RNP coupled to a transposase having an amplification adapter coupled thereto. The Cas-gRNA RNP may be hybridized to a subsequence in the target polynucleotide.