公开(公告)号：US20210151125A1

公开(公告)日：2021-05-20

申请号：US16622822

申请日：2018-06-19

Applicant: ILLUMINA, INC.

Inventor： Yong Li ,  Jocelyne Bruand ,  Ryan Matthew Kelley ,  Chih Lee ,  Konrad Scheffler

IPC: G16B30/00 ,  G16B20/20 ,  G16B5/20

Abstract: Methods and systems are provided for quantifying and deconvolving nucleic acid mixture samples including nucleic acid of one or more contributors having known or unknown genomes. The methods and systems provided herein implement processes that use Bayesian probabilistic modeling techniques to determine the abundances and confidence intervals of genetically distinct contributors in a chimerism sample, thereby improving specificity, accuracy and sensitivity, and greatly expanded the application scope over conventional methods.