公开(公告)号：US20210254170A1

公开(公告)日：2021-08-19

申请号：US17172380

申请日：2021-02-10

Applicant: ILLUMINA, INC.

Inventor： Mahdi Golkaram ,  Shile Zhang ,  Li Liu ,  Aaron Wise ,  Joyee Yao ,  Shannon Kaplan ,  Alex So ,  Michael Salmans ,  Raakhee Vijayaraghavan

IPC: C12Q1/6886

Abstract: A potential prognostic biomarker is based on a combination of a composite score generated by sequence analysis of global human endogenous retrovirus (hERV)/retro-transposon transactivation and a cell signature generated using deconvolution of immune cells within a tumor sample for predicting the efficacy of chemotherapeutic agents and immune checkpoint inhibitors. Correlation analysis of the composite score with cell signature within a tumor sample enables survival analysis in individuals receiving chemotherapeutic agents and immune checkpoint inhibitors.