公开(公告)号：US12145123B2

公开(公告)日：2024-11-19

申请号：US17416465

申请日：2019-12-16

Applicant: IMEC VZW ,  Katholieke Universiteit Leuven

Inventor： Peter Peumans ,  Ahmed Taher ,  Nicolas Vergauwe ,  Benjamin Jones

IPC: B01J19/00 ,  B01L3/00

Abstract: The present invention provides a micro-reactor (1) adapted to host chemical reactions having at least one microfluidic layer, said micro-reactor (1) comprising a fluid inlet (2) and a fluid outlet (3); a plurality of micro-reaction chambers (10) arranged in rows (7) and columns (6), each micro-reaction chamber comprising a chamber inlet (10a) and a chamber outlet (10b); a plurality of supply channels (4) for supplying fluid to from said fluid inlet (2) to said micro-reaction chambers (10) and further arranged for draining said micro-reaction chambers (10) to said fluid outlet (3), said supply channels (10) extending in a first direction (D1) along the columns (6) of micro-reaction chambers (10) and arranged such that there is one supply channel (4) between adjacent columns (6). The micro-reaction chambers (10) in the columns (6) are arranged such that the chamber inlets (10a) of a column are in fluid contact with the same supply channel (4) and the chamber outlets (10b) are in fluid contact with the supply channel (4) adjacent to the supply channel (4) arranged in fluidic contact with the chamber inlets (10a). Further, the plurality of supply channels (4) comprises a first end supply channel (4a) arranged for supplying fluid to a first end column (6a) of the micro-reaction chambers (10) and a second end supply channel (4b) arranged for draining fluid from the second, opposite, end column (6b) of said micro-reaction chambers (10); and wherein the micro-reactor (1) further comprises at least one reagent inlet (8) in fluid contact with the first end supply channel 4a and a reagent outlet (9) in fluid contact with the second end supply channel such that reagents introduced to the at least one reagent inlet (8) fill the plurality of micro-reaction chambers (10) in a second direction (D2) along the rows (7) of micro-reaction chambers (10) to the reagent outlet (9).

公开(公告)号：US11471887B2

公开(公告)日：2022-10-18

申请号：US16693750

申请日：2019-11-25

Applicant: IMEC VZW

Inventor： Peter Peumans ,  Benjamin Jones ,  Nicolas Vergauwe

IPC: B01L3/00

Abstract: A microfluidic device comprising a plurality of microreactors is provided. Each microreactor includes at least a first inlet and a second inlet for supplying a first fluid and a second fluid, respectively, to said microreactor and at least one waste channel for draining fluid from said microreactor. The device further comprises a shared first microfluidic supply system for supplying a first fluid to the first inlets of the plurality of microreactors, a shared second microfluidic supply system for supplying a second fluid to the second inlets of the plurality of microreactors. At least one of said inlets to each microreactor comprises at least one valve-less fluidic resistance element having a fluidic resistance that is substantially larger than the fluidic resistance of the corresponding shared microfluidic supply system. A chemical reaction sequencer apparatus including the microfluidic device and a method for supplying reagents to a plurality of microreactors are also provided.