公开(公告)号：US11262239B2

公开(公告)日：2022-03-01

申请号：US16715351

申请日：2019-12-16

Applicant: IMEC VZW

Inventor： Peter Peumans ,  Pol Van Dorpe ,  Niels Verellen

IPC: G01J3/28 ,  G01J3/02 ,  G01J3/26 ,  G01J3/36 ,  G01N15/14

Abstract: The present disclosure relates to a spectral sensor for detection of individual light-emitting particles. The sensor is comprising an array of photo-sensitive detectors for detecting light emitted by said individual light-emitting particles and a filter array comprising a plurality of different band-stop filters. The filter array is configured to transmit wavelengths in a detectable wavelength region to the array of photo-sensitive detectors, and wherein each band-stop filter is associated with one or more particular photo-sensitive detectors, and the plurality of different band-stop filters are configured to reflect different wavelength intervals within said detectable wavelength region so that each photo-sensitive detector of the array is configured to detect the wavelengths of the detectable wavelength region other than the reflected wavelength interval of the band-stop filter being associated with the photo-sensitive detector. The sensor is further comprising a processing unit in communication with said array of photo-sensitive detectors and configured for determining a spectral characteristic of an individual light-emitting particle based on the response from said array of photo-sensitive detectors.

公开(公告)号：US09909992B2

公开(公告)日：2018-03-06

申请号：US15119055

申请日：2015-02-28

Applicant: IMEC VZW

Inventor： Pol Van Dorpe ,  Peter Peumans

IPC: G01J3/30 ,  G01N21/65 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  G01J3/02 ,  G01J3/36 ,  G01J3/44 ,  G01J3/26 ,  G01N33/49 ,  G01J3/12

CPC classification number: G01N21/65 ,  A61B5/0066 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/443 ,  A61B2562/0233 ,  A61B2562/0238 ,  G01J1/0204 ,  G01J1/0425 ,  G01J1/0477 ,  G01J3/0205 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/0227 ,  G01J3/0256 ,  G01J3/0264 ,  G01J3/0291 ,  G01J3/1895 ,  G01J3/26 ,  G01J3/36 ,  G01J3/44 ,  G01J2003/1213 ,  G01N33/49 ,  G01N2201/06113 ,  G01N2201/0633 ,  G01N2201/0636 ,  G02B6/0026 ,  G02B6/0031 ,  G02B6/0038 ,  G02B6/0048

Abstract: The present disclosure relates to systems, methods, and sensors configured to characterize a radiation beam. At least one embodiment relates to an optical system. The optical system includes an optical radiation guiding system. The optical radiation guiding system includes a collimator configured to collimate the radiation beam into a collimated radiation beam. The optical radiation guiding system also includes a beam shaper configured to distribute power of the collimated radiation beam over a discrete number of line shaped fields. A spectrum of the collimated radiation beam entering the beam shaper is delivered to each of the discrete number of line shaped fields. The optical system further includes a spectrometer chip. The spectrometer chip is configured to process the spectrum of the collimated radiation beam in each of the discrete number of line shaped fields coming from the beam shaper.

公开(公告)号：US20170341078A1

公开(公告)日：2017-11-30

申请号：US15526922

申请日：2015-11-19

Applicant: IMEC VZW

Inventor： Chengxun Liu ,  Peter Peumans ,  Liesbet Lagae ,  Bivragh Majeed

IPC: B01L3/00 ,  G01N15/10 ,  G01N15/14

CPC classification number: B01L3/502761 ,  B01L2200/0652 ,  B01L2300/0645 ,  B01L2300/0864 ,  B01L2300/1827 ,  B01L2400/0442 ,  B01L2400/046 ,  B01L2400/06 ,  G01N2015/1006 ,  G01N2015/149

Abstract: The present disclosure relates to microbubble generator devices for deflecting objects in a liquid, systems for sorting objects that utilize such devices, and methods for fabricating such devices. At least one embodiment relates to a micro-fluidic device for deflecting objects in a liquid. The device includes a substrate for providing an object-containing liquid thereon. The device also includes a microbubble generator that includes at least one microbubble generating element. The microbubble generator is located on a surface of the substrate and in direct contact with the object-containing liquid when the object-containing liquid is provided on the substrate. The at least one microbubble generating element is configured to deflect a single object in the object-containing liquid through generation of a plurality of microbubbles.

公开(公告)号：US20170326551A1

公开(公告)日：2017-11-16

申请号：US15529424

申请日：2015-11-24

Applicant: IMEC VZW

Inventor： Peter Peumans ,  Liesbet Lagae ,  Paolo Fiorini

IPC: B01L3/00 ,  G01N1/14 ,  G01N1/38 ,  G01N33/49

CPC classification number: B01L3/502715 ,  B01L3/5027 ,  B01L3/502707 ,  B01L3/50273 ,  B01L2200/027 ,  B01L2200/10 ,  B01L2300/041 ,  B01L2300/044 ,  B01L2300/046 ,  B01L2300/0627 ,  B01L2300/0645 ,  B01L2300/0672 ,  B01L2300/0816 ,  B01L2300/0825 ,  B01L2300/0848 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2300/0883 ,  B01L2300/0887 ,  B01L2300/1827 ,  B01L2400/0406 ,  B01L2400/049 ,  B01L2400/0683 ,  B01L2400/086 ,  G01N1/14 ,  G01N1/38 ,  G01N33/49 ,  G01N2001/386

Abstract: The present disclosure relates to a fluid analysis device which comprises a sensing device for analyzing a fluid sample, the sensing device comprising a micro-fluidic component for propagating the fluid sample and a microchip configured for sensing the fluid sample in the micro-fluidic component; a sealed fluid compartment containing a further fluid, the compartment being fluid-tight connected to the sensing device and adapted for providing the further fluid to the micro-fluidic component when the sealed fluid compartment is opened; and an inlet for providing the fluid sample to the micro-fluidic component. Further, the present disclosure relates to a method for sensing a fluid sample using the fluid analysis device.

公开(公告)号：US09599509B2

公开(公告)日：2017-03-21

申请号：US14934722

申请日：2015-11-06

Applicant: SAMSUNG ELECTRONICS CO., LTD. ,  IMEC VZW

Inventor： Peter Peumans ,  Seongho Cho ,  Woochang Lee

IPC: G01N21/00 ,  G01J3/02 ,  G01J3/44 ,  A61B5/00 ,  G01N21/359 ,  G01N21/65 ,  A61B5/11 ,  A61B5/145 ,  G01J3/28

CPC classification number: G01J3/0289 ,  A61B5/0059 ,  A61B5/0075 ,  A61B5/11 ,  A61B5/14532 ,  A61B5/441 ,  A61B5/721 ,  A61B2562/0233 ,  A61B2562/04 ,  G01J3/28 ,  G01J3/44 ,  G01N21/359 ,  G01N21/65

Abstract: A spectroscopy system includes detectors configured to obtain detection spectrums of respective detection areas that are located at different positions of an object; and an information processor configured to obtain a target spectrum of a target area by using position information of the detection areas and the detection spectrums obtained by the detectors.

公开(公告)号：US20150353351A1

公开(公告)日：2015-12-10

申请号：US14824695

申请日：2015-08-12

Applicant: IMEC VZW

Inventor： Liesbet Lagae ,  Peter Peumans

IPC: B81C1/00 ,  G01N27/414

CPC classification number: B81C1/00539 ,  A61B5/1411 ,  A61B5/150022 ,  A61B5/150221 ,  A61B5/150274 ,  A61B5/150358 ,  A61B5/15087 ,  B01L3/502707 ,  B01L3/502715 ,  B01L3/50273 ,  B01L7/52 ,  B01L2300/046 ,  B01L2300/0645 ,  B01L2300/0663 ,  B01L2300/0681 ,  B01L2300/0819 ,  B01L2300/0887 ,  B01L2300/123 ,  B01L2300/1833 ,  B01L2400/0406 ,  B01L2400/0415 ,  B01L2400/0688 ,  B01L2400/086 ,  B81C1/00238 ,  F15C5/00 ,  F15C7/00 ,  G01N27/227 ,  G01N27/4148 ,  Y10T29/494 ,  Y10T436/143333

Abstract: The present disclosure relates to a device for analyzing a fluid sample. In one aspect, the device includes a fluidic substrate that comprises a micro-fluidic component embedded in the fluidic substrate configured to propagate a fluid sample via capillary force through the device and a means for providing a fluid sample connected to the micro-fluidic component. The device also includes a lid attached to the fluidic substrate at least partly covering the fluidic substrate and at least partly closing the micro-fluidic component. The fluidic substrate may be a silicon fluidic substrate and the lid may be a CMOS chip. In another aspect, embodiments of the present disclosure relate to a method for fabricating such a device, and the method may include providing a fluidic substrate, providing a lid, and attaching, through a CMOS compatible bonding process, the fluidic substrate to the lid to close the fluidic substrate at least partly.

公开(公告)号：US20240226893A1

公开(公告)日：2024-07-11

申请号：US18559029

申请日：2022-05-12

Applicant: IMEC VZW ,  Janssen Biotech Inc.

Inventor： Peter Peumans ,  Olivier Henry ,  Willem Van Roy ,  Tim Stakenborg ,  Alexander Graham Irwin Tulloch

IPC: B01L3/00

CPC classification number: B01L3/502761 ,  B01L3/502715 ,  B01L2200/0652 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/161 ,  B01L2400/086 ,  B01L2400/088

Abstract: A device for sorting biological cells comprises a flow channel configured to pass a flow of liquid carrying the biological cells. The flow channel comprises at least one zone associated with a cell category. Each zone of the flow channel comprises at least one surface coated with molecules having an affinity to the cell category associated with the zone, the at least one surface of the zone being configured to modify, by the molecules of the surface, a movement of a cell belonging to the associated cell category of the zone as the cell passes the zone. The device comprises a detector configured to detect a cell exhibiting at least one modified movement in one zone of the flow channel, and to transmit a trigger signal based on the detection of the cell. The device further comprises an actuator configured to divert the detected cell based on the trigger signal.

公开(公告)号：US20180361381A1

公开(公告)日：2018-12-20

申请号：US16058828

申请日：2018-08-08

Applicant: IMEC VZW

Inventor： Peter Peumans ,  Liesbet Lagae ,  Paolo Fiorini

IPC: B01L3/00 ,  A61B5/15 ,  A61B5/151 ,  A61B5/157

Abstract: The present disclosure relates to a fluid analyzing device that includes a sensing device for analyzing a fluid sample. The sensing device includes a microchip configured for sensing the fluid sample, and a closed micro-fluidic component for propagating the fluid sample to the microchip. The fluid sample can be provided to the micro-fluidic component via an inlet of the fluid analyzing device. And a vacuum compartment, which is air-tight connected to the sensing device, can create in the micro-fluidic component a suction force suitable for propagating the fluid sample through the micro-fluidic component.

公开(公告)号：US20170100064A1

公开(公告)日：2017-04-13

申请号：US15100067

申请日：2014-12-03

Applicant: IMEC VZW

Inventor： Pol Van Dorpe ,  Peter Peumans

IPC: A61B5/1455 ,  A61B5/145 ,  A61B5/00

CPC classification number: A61B5/1455 ,  A61B5/0066 ,  A61B5/0075 ,  A61B5/1451 ,  A61B5/14532 ,  A61B5/443 ,  A61B5/681 ,  A61B2562/0233 ,  G01B9/02091 ,  G01J3/0256 ,  G01J3/0291 ,  G01J3/44 ,  G01N21/35 ,  G01N21/65 ,  G01N2201/0633 ,  G01N2201/0636 ,  G01N2201/12

Abstract: The present disclosure relates to devices and methods for non-invasive measuring of analytes. At least one embodiment relates to a wearable system for non-invasive measuring of a concentration of an analyte in skin tissue. The wearable system includes an integrated circuit that includes a first optical unit. The first optical unit includes a Raman spectrometer. The first optical unit also includes an OCT spectrometer and an interferometer optically coupled to the OCT spectrometer or an infrared (IR) spectrometer. The first optical unit additionally includes a light coupler. The wearable system further includes a first light source for performing Raman spectroscopy. The wearable system additionally includes a second light source for performing OCT spectroscopy or IR spectroscopy. Still further, the wearable system includes read-out electronics to determine an optical model of the skin tissue based on the spectroscopic data and to determine the concentration of the analyte.

公开(公告)号：US20150093816A1

公开(公告)日：2015-04-02

申请号：US14567301

申请日：2014-12-11

Applicant: IMEC VZW

Inventor： Liesbet Lagae ,  Peter Peumans

IPC: B01L3/00 ,  A61B5/15 ,  B01L7/00 ,  G01N27/22 ,  F15C5/00 ,  F15C7/00

CPC classification number: B81C1/00539 ,  A61B5/1411 ,  A61B5/150022 ,  A61B5/150221 ,  A61B5/150274 ,  A61B5/150358 ,  A61B5/15087 ,  B01L3/502707 ,  B01L3/502715 ,  B01L3/50273 ,  B01L7/52 ,  B01L2300/046 ,  B01L2300/0645 ,  B01L2300/0663 ,  B01L2300/0681 ,  B01L2300/0819 ,  B01L2300/0887 ,  B01L2300/123 ,  B01L2300/1833 ,  B01L2400/0406 ,  B01L2400/0415 ,  B01L2400/0688 ,  B01L2400/086 ,  B81C1/00238 ,  F15C5/00 ,  F15C7/00 ,  G01N27/227 ,  G01N27/4148 ,  Y10T29/494 ,  Y10T436/143333

Abstract: The present disclosure relates to a device for analyzing a fluid sample. In one aspect, the device includes a fluidic substrate that comprises a micro-fluidic component embedded in the fluidic substrate configured to propagate a fluid sample via capillary force through the device and a means for providing a fluid sample connected to the micro-fluidic component. The device also includes a lid attached to the fluidic substrate at least partly covering the fluidic substrate and at least partly closing the micro-fluidic component. The fluidic substrate may be a silicon fluidic substrate and the lid may be a CMOS chip. In another aspect, embodiments of the present disclosure relate to a method for fabricating such a device, and the method may include providing a fluidic substrate, providing a lid, and attaching, through a CMOS compatible bonding process, the fluidic substrate to the lid to close the fluidic substrate at least partly.

Abstract translation: 本公开涉及一种用于分析流体样品的装置。 在一个方面，该装置包括流体基底，其包括嵌入在流体衬底中的微流体组分，该微流体组分构造成通过毛细管力将流体样品传播通过该装置，以及用于提供连接到微流体组分的流体样品的装置。 该装置还包括附接到流体基底的盖子，至少部分地覆盖流体基底并且至少部分地封闭微流体部件。 流体衬底可以是硅流体衬底，并且盖子可以是CMOS芯片。 在另一方面，本公开的实施例涉及一种用于制造这种装置的方法，并且该方法可以包括提供流体衬底，提供盖子，以及通过CMOS兼容的粘合工艺将流体衬底附接到盖子 至少部分关闭流体底物。