公开(公告)号：US20210371518A1

公开(公告)日：2021-12-02

申请号：US17275838

申请日：2019-09-12

Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM ,  IMMUNE-ONC THERAPEUTICS, INC.

Inventor： Zhiqiang AN ,  Chengcheng ZHANG ,  Ningyan ZHANG ,  Xun GUI ,  Mi DENG ,  Tao HUANG ,  Qiang LIU ,  X. Charlene LIAO

IPC: C07K16/28 ,  A61P35/02 ,  A61K45/06 ,  A61K39/395 ,  A61K47/68 ,  A61K51/10 ,  G01N33/574 ,  A61K47/69

Abstract: The present disclosure provides an isolated monoclonal antibody or an antigen-binding fragment thereof that binds specifically to leukocyte immunoglobulin-like receptor 4 (LILRB4). In certain embodiments, the antibody or antigen-binding fragment, when bound to LILRB4, modulates the activation of LILRB4. In certain embodiments, the antibody or antigen-binding fragment, when bound to LILRB4, activates LILRB4. In certain embodiments, the antibody or antigen binding fragment, when bound to LILRB4, suppresses activation of LILRB4. In certain embodiments, the antibody or antigen-binding fragment, when bound to LILRB4, specifically blocks binding of ApoE to LILRB4. In another aspect, there is provided a method of treating or ameliorating the effects of a cancer in a subject, comprising administering to the subject a therapeutically effective amount of the antibody or an antigen-binding fragment thereof or an engineered cell as provided herein.

公开(公告)号：US20230340114A1

公开(公告)日：2023-10-26

申请号：US17905943

申请日：2021-03-12

Applicant: IMMUNE-ONC THERAPEUTICS, INC.

Inventor： An SONG ,  Tao HUANG ,  Ryan STAFFORD ,  Maria Jose COSTA ,  Kyu Hee HONG ,  Caroline BONNANS ,  Jianhui ZHOU ,  Li ZHOU ,  Ji LI ,  J. Paul WOODARD ,  X. Charlene LIAO

IPC: C07K16/28 ,  A61K45/06 ,  A61K39/395 ,  C12N5/0783 ,  A61K39/00 ,  C07K14/705 ,  C07K14/725 ,  A61P35/02 ,  A61K38/17

CPC classification number: C07K16/2803 ,  C07K16/2809 ,  A61K45/06 ,  A61K39/3955 ,  C12N5/0636 ,  A61K39/4611 ,  A61K39/4622 ,  C07K14/70517 ,  C07K14/70521 ,  C07K14/70578 ,  C07K14/7051 ,  A61K39/4631 ,  A61P35/02 ,  A61K38/1774 ,  A61K38/177 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/732 ,  C07K2317/73 ,  C07K2319/33 ,  C07K2317/622 ,  C07K2319/03 ,  C07K2319/02 ,  A61K2239/21 ,  A61K2239/22 ,  A61K2239/29 ,  C07K2317/92

Abstract: The present disclosure provides anti-LILRB4 antibodies or antigen-binding fragments thereof, anti-LILRB4 chimeric antigen receptor protein, isolated polynucleotides encoding the same, pharmaceutical compositions comprising the same, and the uses thereof.