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公开(公告)号：US20140296551A1
公开(公告)日：2014-10-02
申请号：US14212594
申请日：2014-03-14
发明人： Duxin Sun , Hongwei Chen , Wei Qian , Yong Che , Masayuki Ito , Hayley Paholak , Kanokwan Sansanaphongpricha
IPC分类号： C08G65/48
CPC分类号： C08G65/48 , A61K41/0052 , A61K47/50 , A61K47/60 , A61K49/0065 , C08G65/3344
摘要： The present invention relates to methods, compositions, and kits for generating conjugated gold nanoparticles. In certain embodiments, the present invention provides methods of generating unsaturated conjugated gold nanoparticles by mixing naked gold nanoparticles with a first type of attachment molecules at a molar ratio such that the attachment molecules attach to the naked gold particles at a density level below the saturation level of the naked gold particles (e.g., at a saturation level of 1-99%). In some embodiments, a second type of attachment molecules (e.g., with the opposite charge as the first type of attachment molecules) are mixed with the unsaturated conjugated gold nanoparticles to generate double-conjugated gold nanoparticles (e.g., that are zwitterionic)
摘要翻译： 本发明涉及用于产生共轭金纳米颗粒的方法，组合物和试剂盒。 在某些实施方案中，本发明提供了通过将裸金纳米颗粒与第一类型附着分子以摩尔比混合以使得附着分子以低于饱和水平的密度水平附着于裸金颗粒的方式来产生不饱和共轭金纳米颗粒的方法 的裸金粒子（例如，在1-99％的饱和度水平）。 在一些实施方案中，将第二类型的附着分子（例如，具有相反电荷作为第一类型的附着分子）与不饱和共轭金纳米颗粒混合以产生双共轭金纳米颗粒（例如，两性离子）
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公开(公告)号：US20130243874A1
公开(公告)日：2013-09-19
申请号：US13783563
申请日：2013-03-04
发明人： Duxin Sun , Hongwei Chen , Masayuki Ito , Wei Qian , Yong Che
CPC分类号： A61K47/02 , A61K9/143 , B22F1/0022 , B22F1/0062 , B82Y30/00 , G01N21/47
摘要： The present provides amphiphilic block copolymer coated surfaces (e.g., nanoparticles, medical devices, etc.) and methods of preparing such surfaces. In certain embodiments, the present invention provides amphiphilic block copolymer coated single dispersed nanoparticles, which are stable in buffer (e.g., PBS) and have neutral but functionable surfaces, and methods of preparing the same.
摘要翻译： 本发明提供两亲嵌段共聚物涂覆表面（例如纳米颗粒，医疗装置等）和制备这种表面的方法。 在某些实施方案中，本发明提供了两性嵌段共聚物涂覆的单分散纳米颗粒，其在缓冲液（例如，PBS）中是稳定的并且具有中性但可功能的表面及其制备方法。
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公开(公告)号：US09587071B2
公开(公告)日：2017-03-07
申请号：US14962619
申请日：2015-12-08
发明人： Duxin Sun , Hongwei Chen , Wei Qian , Yong Che , Masayuki Ito , Hayley Paholak , Kanokwan Sansanaphongpricha
IPC分类号： C08G65/48 , A61K47/48 , C08G65/334 , A61K41/00 , A61K49/00
CPC分类号： C08G65/48 , A61K41/0052 , A61K47/50 , A61K47/60 , A61K49/0065 , C08G65/3344
摘要： The present invention relates to methods, compositions, and kits for generating conjugated gold nanoparticles. In certain embodiments, the present invention provides methods of generating unsaturated conjugated gold nanoparticles by mixing naked gold nanoparticles with a first type of attachment molecules at a molar ratio such that the attachment molecules attach to the naked gold particles at a density level below the saturation level of the naked gold particles (e.g., at a saturation level of 1-99%). In some embodiments, a second type of attachment molecules (e.g., with the opposite charge as the first type of attachment molecules) are mixed with the unsaturated conjugated gold nanoparticles to generate double-conjugated gold nanoparticles (e.g., that are zwitterionic).
摘要翻译： 本发明涉及用于产生共轭金纳米颗粒的方法，组合物和试剂盒。 在某些实施方案中，本发明提供了通过将裸金纳米颗粒与第一类型附着分子以摩尔比混合以使得附着分子以低于饱和水平的密度水平附着于裸金颗粒的方式来产生不饱和共轭金纳米颗粒的方法 的裸金粒子（例如，在1-99％的饱和度水平）。 在一些实施方案中，将第二类型的附着分子（例如，具有相反电荷作为第一类型的附着分子）与不饱和共轭金纳米颗粒混合以产生双共轭金纳米颗粒（例如，两性离子）。
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公开(公告)号：US20160090446A1
公开(公告)日：2016-03-31
申请号：US14962619
申请日：2015-12-08
发明人： Duxin Sun , Hongwei Chen , Wei Qian , Yong Che , Masayuki Ito , Hayley Paholak , Kanokwan Sansanaphongpricha
IPC分类号： C08G65/48
CPC分类号： C08G65/48 , A61K41/0052 , A61K47/50 , A61K47/60 , A61K49/0065 , C08G65/3344
摘要： The present invention relates to methods, compositions, and kits for generating conjugated gold nanoparticles. In certain embodiments, the present invention provides methods of generating unsaturated conjugated gold nanoparticles by mixing naked gold nanoparticles with a first type of attachment molecules at a molar ratio such that the attachment molecules attach to the naked gold particles at a density level below the saturation level of the naked gold particles (e.g., at a saturation level of 1-99%). In some embodiments, a second type of attachment molecules (e.g., with the opposite charge as the first type of attachment molecules) are mixed with the unsaturated conjugated gold nanoparticles to generate double-conjugated gold nanoparticles (e.g., that are zwitterionic).
摘要翻译： 本发明涉及用于产生共轭金纳米颗粒的方法，组合物和试剂盒。 在某些实施方案中，本发明提供了通过将裸金纳米颗粒与第一类型附着分子以摩尔比混合以使得附着分子以低于饱和水平的密度水平附着于裸金颗粒的方式来产生不饱和共轭金纳米颗粒的方法 的裸金粒子（例如，在1-99％的饱和度水平）。 在一些实施方案中，将第二类型的附着分子（例如，具有相反电荷作为第一类型的附着分子）与不饱和共轭金纳米颗粒混合以产生双共轭金纳米颗粒（例如，两性离子）。
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公开(公告)号：US09234078B2
公开(公告)日：2016-01-12
申请号：US14212594
申请日：2014-03-14
发明人： Duxin Sun , Hongwei Chen , Wei Qian , Yong Che , Masayuki Ito , Hayley Paholak , Kanokwan Sansanaphongpricha
IPC分类号： C08G65/48 , A61K47/48 , C08G65/334 , A61K41/00 , A61K49/00
CPC分类号： C08G65/48 , A61K41/0052 , A61K47/50 , A61K47/60 , A61K49/0065 , C08G65/3344
摘要： The present invention relates to methods, compositions, and kits for generating conjugated gold nanoparticles. In certain embodiments, the present invention provides methods of generating unsaturated conjugated gold nanoparticles by mixing naked gold nanoparticles with a first type of attachment molecules at a molar ratio such that the attachment molecules attach to the naked gold particles at a density level below the saturation level of the naked gold particles (e.g., at a saturation level of 1-99%). In some embodiments, a second type of attachment molecules (e.g., with the opposite charge as the first type of attachment molecules) are mixed with the unsaturated conjugated gold nanoparticles to generate double-conjugated gold nanoparticles (e.g., that are zwitterionic).
摘要翻译： 本发明涉及用于产生共轭金纳米颗粒的方法，组合物和试剂盒。 在某些实施方案中，本发明提供了通过将裸金纳米颗粒与第一类型附着分子以摩尔比混合以使得附着分子以低于饱和水平的密度水平附着于裸金颗粒的方式来产生不饱和共轭金纳米颗粒的方法 的裸金粒子（例如，在1-99％的饱和度水平）。 在一些实施方案中，将第二类型的附着分子（例如，具有相反电荷作为第一类型的附着分子）与不饱和共轭金纳米颗粒混合以产生双共轭金纳米颗粒（例如，两性离子）。
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