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公开(公告)号：US11696579B2
公开(公告)日：2023-07-11
申请号：US16955539
申请日：2018-12-18
申请人： IMV TECHNOLOGIES , UNIVERSITE GRENOBLE ALPES , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , SWISSGENETICS
IPC分类号： A01N1/02 , A61D19/02 , A61K31/14 , A61K31/4748
CPC分类号： A01N1/0226 , A01N1/0221 , A61D19/024 , A61D19/027 , A61K31/14 , A61K31/4748
摘要： The invention relates to a method for increasing the lifespan of animal sperm comprising contacting said sperm with an inhibitor of Slo3 potassium channel. The invention also relates to a use of an inhibitor of Slo3 potassium channel, for increasing the lifespan of animal sperm or motility of capacitated animal sperm, comprising contacting an inhibitor of Slo3 potassium channel with said sperm. Moreover, the invention relates to an artificial insemination instrument for use in artificial insemination of an animal, comprising animal sperm in contact with an inhibitor of Slo3 potassium channel. The invention also relates to a method for artificially inseminating an animal using said artificial insemination instrument. Eventually, the invention relates to a method for increasing the fertility of an animal, comprising contacting sperm of said animal with an inhibitor of Slo3 potassium channel; then artificially inseminating said animal with said sperm.
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公开(公告)号：US10729745B2
公开(公告)日：2020-08-04
申请号：US16306289
申请日：2017-06-01
申请人： IMV Technologies
IPC分类号： A61K35/646 , A61K38/17 , C07K14/435 , A61P15/08 , G01N33/50
摘要： The invention relates to a La-1-like peptide agent that increases sperm motility. It is non-toxic and it may be used to treat male infertility in humans, and also to increase fertility in animals. It may be used in artificial reproductive techniques such as in vitro fertilisation (IVF), including intra-cytoplasmic sperm injection (ICSI). The La-1 like peptide agent may also be used in artificial insemination techniques such as intra-cytoplasmic uterine injection (IUI).
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