专利检索 ap:("INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION") AND inv:"Alexander ZAYKOV" 第 1 页

1.

发明申请
INSULIN RECEPTOR PARTIAL AGONISTS 审中-公开

公开(公告)号：US20170313755A1

公开(公告)日：2017-11-02

申请号：US15487768

申请日：2017-04-14

申请人： INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION

发明人： Richard D. DiMARCHI , Sarah J. BRANDT , Alexander ZAYKOV , Yan ZHAO

IPC分类号： C07K14/62 , C07K14/00 , A61K38/00

CPC分类号： C07K14/62 , A61K38/00

摘要： Disclosed herein are insulin analog conjugates comprising an insulin agonist covalently linked to an insulin antagonist peptide. The conjugates are high potency insulin agonists but with decreased maximal activity relative to the maximal activity of native insulin.