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    Systems and methods for accurate measurement of proprioception
    2.
    发明授权
    Systems and methods for accurate measurement of proprioception 有权

    公开(公告)号：US12178599B2

    公开(公告)日：2024-12-31

    申请号：US16324228

    申请日：2017-08-11

    Applicant: Indiana University Research and Technology Corporation

    Inventor： Hannah J. Block

    IPC: A61B5/00 ,  A61B5/11

    Abstract: Stands for measuring proprioception comprising a hand layer comprising one or more vertically offset portions configured to ensure proper placement of a patient's hand in a predetermined position, a top cover coupled to the hand layer, wherein the top cover is designed to obscure the patient's view of the patient's hand, and a support element coupled to the hand layer and configured to support the hand layer at a predetermined angle are disclosed. Methods for measuring proprioception are also disclosed.

    Precision medicine for treating and preventing suicidality
    10.
    发明授权
    Precision medicine for treating and preventing suicidality 有权

    公开(公告)号：US11608532B2

    公开(公告)日：2023-03-21

    申请号：US16677414

    申请日：2019-11-07

    Applicant: Indiana University Research and Technology Corporation ,  United States Government as Represented by the Department of Veterans Affairs

    Inventor： Alexander Bogdan Niculescu

    IPC: C12Q1/6883 ,  G16H10/60 ,  G16H50/20 ,  G16B50/30 ,  A61K45/06

    Abstract: The present disclosure relates generally to discovery of novel compounds involved in the treatment and prevention of suicidality by bioinformatics drug repurposing using novel genes expression biomarkers involved in suicidality. Disclosed are methods for assessing severity, determining future risk, matching with a drug treatment, and measuring response to treatment, for suicidality. Also disclosed are new methods of use for drugs and natural compounds repurposed for use in preventing and treating suicidality. These methods include computer-assisted methods analyzing the expression of panels of genes, clinical measures, and drug databases. Detailed herein are methods using a universal approach, in everybody, as well as personalized approaches by gender, and by diagnosis. The discovery describes compounds for use in everybody (universal), as well as personalized by gender (males, females), diagnosis (bipolar, depression), gender and diagnosis combined (male bipolar, male depression), male PTSD, male SZ/SZA), and subtypes of suicidality (high anxiety, low mood, combined (affective), and high psychosis (non-affective). Also disclosed are methods for identifying which subjects should be receiving which treatment, using genes expression biomarkers for patient stratification and measuring response to treatment. The disclosure also relates to algorithms, universal and personalized by gender and diagnosis. The algorithms combine biomarkers as well as clinical measures for suicidality and for mental state, in order to identify subjects who are at risk of committing suicide, as well as to track responses to treatments. The disclosure further relates to determining subtypes of suicidality. Such subtypes may delineate groups of individuals that are more homogenous in terms of biology, behavior, and response to treatment.

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