公开(公告)号：US11351268B2

公开(公告)日：2022-06-07

申请号：US16983726

申请日：2020-08-03

Applicant: INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION

Inventor： Richard D. DiMarchi ,  Alexei Kharitonenkov ,  Pengyun Li ,  Archita S. Agrawal

IPC: A61K47/66 ,  C07K14/50 ,  A61K47/65 ,  A61P3/04 ,  A61P3/10 ,  A61K38/03 ,  A61K38/17 ,  A61K38/26 ,  A61K38/28

Abstract: Disclosed herein are modified C-terminal fragments of FGF21 optimized for binding to Klotho β or antagonizing FGF21 activity. FGF21 peptides modified to comprise modifications to the C-terminal amino acid sequence are disclosed that have enhanced activity at the FGF21 receptor. Additionally, conjugates formed between the optimized FGF21 peptide fragments and insulin like peptides or nuclear hormone receptor ligands are provided.