公开(公告)号：US20240285557A1

公开(公告)日：2024-08-29

申请号：US18572480

申请日：2022-06-24

申请人： INDUSTRY FOUNDATION OF CHONNAM NATIONAL UNIVERSITY ,  KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY

发明人： Kyoung Oh CHO ,  Tae ll JEON ,  Sun Woo LEE ,  Yeong Bin BAEK ,  Hyung Jun Kwon ,  Hueng Sik CHOI ,  Sang lk PARK ,  Muhammad SHARIF ,  Jeong Ah LIM

IPC分类号： A61K31/17 ,  A61K31/215 ,  A61K31/675 ,  A61P31/14 ,  A61P31/16

CPC分类号： A61K31/17 ,  A61K31/215 ,  A61K31/675 ,  A61P31/14 ,  A61P31/16

摘要： The present invention relates to a therapeutic agent of a lipase inhibitor for a wide spectrum of RNA viral infections in humans and animals. More specifically, the lipase inhibitor can be used as a therapeutic agent for influenza A virus infection, bovine coronavirus infection, porcine epidemic diarrhea coronavirus infection, bovine rotavirus infection, porcine reproductive and respiratory syndrome virus infection, and sapoviral infection and furthermore, can be utilized as a therapeutic agent for various RNA viral infections in humans and animals, such as infections with SARS COV-1, MERS-COV, Zika virus, dengue fever virus, and hepatitis A and C viruses.

公开(公告)号：US20230234913A1

公开(公告)日：2023-07-27

申请号：US18007911

申请日：2021-02-02

申请人： INDUSTRY FOUNDATION OF CHONNAM NATIONAL UNIVERSITY

发明人： Sun Woo LEE

IPC分类号： C07C231/08

CPC分类号： C07C231/08

摘要： The present invention relates to a method for preparing primary amides from tertiary or secondary amides substituted with various alkyl groups through a transamidation reaction without a metal catalyst in room-temperature conditions by adding ammonium carbonate ((NH4)2CO3), wherein the method is eco-friendly since various secondary and tertiary amides that are not toxic or corrosive are used as starting materials and ammonium carbonate ((NH4)2CO3) that is neither a strong acid nor a strong base is used, and the method is economical since various primary amides can be synthesized with an excellent yield at room temperature without a metal catalyst.

公开(公告)号：US20220313633A1

公开(公告)日：2022-10-06

申请号：US17627914

申请日：2020-07-13

申请人： INDUSTRY FOUNDATION OF CHONNAM NATIONAL UNIVERSITY

发明人： Tae Hoon LEE ,  Sun Woo LEE ,  Eun Jin CHO ,  Sang Hyun MIN ,  Geun Joong KIM ,  Dong Kyu CHOI

IPC分类号： A61K31/18 ,  A61P19/10

摘要： A composition according to an embodiment of the present disclosure includes a N-phenyl-methylsulfonamido-acetamide compound represented by Formula 1. The composition may inhibit osteoclast differentiation and/or formation and exhibit excellent prophylactic or therapeutic effects on various bone diseases including periodontitis and the like. A method for treating a bone disease caused by hyperdifferentiation of osteoclasts according to an embodiment of the present disclosure includes administering to a subject in need thereof the composition.

公开(公告)号：US20220274935A1

公开(公告)日：2022-09-01

申请号：US17627912

申请日：2020-07-14

申请人： INDUSTRY FOUNDATION OF CHONNAM NATIONAL UNIVERSITY

发明人： Tae Hoon LEE ,  Sun Woo LEE ,  Geun Joong KIM ,  Eun Jin CHO ,  Zhihao CHEN ,  Mina DING ,  Sang Hyun MIN ,  Dong Kyu CHOI

IPC分类号： C07D241/04 ,  A61P19/08 ,  A23L33/00 ,  A23L33/10

摘要： A composition according to an embodiment of the present disclosure includes a compound represented by Formula 1. The composition may inhibit osteoclast differentiation and/or formation and exhibit excellent prophylactic or therapeutic effects on various bone diseases including periodontitis and the like. A method for treating a bone disease caused by hyperdifferentiation of osteoclasts according to an embodiment of the present disclosure includes administering to a subject in need thereof the composition.