公开(公告)号：US09649350B2

公开(公告)日：2017-05-16

申请号：US14556055

申请日：2014-11-28

Applicant: INDUSTRY-ACADEMIC COOPERATION FOUNDATION, CHOSUN UNIVERSITY

Inventor： Cheol-Hee Choi ,  Hoon Cho ,  Young-Sook Moon ,  Ji-Won Han ,  Ju-Hee Han

IPC: A61K36/25 ,  A23L33/105

CPC classification number: A61K36/25 ,  A23L33/105 ,  A23V2002/00 ,  A23V2200/30 ,  A23V2200/3202 ,  A23V2250/21

Abstract: Provided is a 15-PGDH activity adjusting function of a Dendropanax morbifera extract. More specifically, since it has been confirmed that the Dendropanax morbifera extract has an outstanding effect in suppressing 15-PGDH activity and so increasing PGE2, a composition of the present invention which contains the Dendropanax morbifera extract as an active ingredient has the advantage of being able to be used for producing a functional health food and a therapeutic agent for a disease associated with PGE2.

公开(公告)号：US10130668B2

公开(公告)日：2018-11-20

申请号：US14414883

申请日：2013-01-30

Applicant: INDUSTRY-ACADEMIC COOPERATION FOUNDATION, CHOSUN UNIVERSITY

Inventor： Cheol-Hee Choi ,  Young-Sook Moon ,  Ju-Hee Han ,  Kyoung-In Lee ,  Hyun-Jung Kim

IPC: A61K36/25 ,  A23L33/105

Abstract: Provided is a use of Dendropanax morbifera extract as an agent for preventing and treating benign prostatic hyperplasia, and more particularly, a composition for preventing and treating benign prostatic hyperplasia and a functional health food for preventing and reducing the effects of benign prostatic hyperplasia, in which the composition and food include, as an active ingredient, a Dendropanax morbifera extract or a compound which is isolated from the extract and then purified.

公开(公告)号：US20150182571A1

公开(公告)日：2015-07-02

申请号：US14414883

申请日：2013-01-30

Applicant: INDUSTRY-ACADEMIC COOPERATION FOUNDATION, CHOSUN UNIVERSITY

Inventor： Cheol-Hee Choi ,  Young-Sook Moon ,  Ju-Hee Han ,  Kyoung-In Lee ,  Hyun-Jung Kim

IPC: A61K36/25 ,  A23L1/30

CPC classification number: A61K36/25 ,  A23L33/105

Abstract: Provided is a use of Dendropanax morbifera extract as an agent for preventing and treating benign prostatic hyperplasia, and more particularly, a composition for preventing and treating benign prostatic hyperplasia and a functional health food for preventing and reducing the effects of benign prostatic hyperplasia, in which the composition and food include, as an active ingredient, a Dendropanax morbifera extract or a compound which is isolated from the extract and then purified. The Dendropanax morbifera extract and the compound isolated from the extract have been demonstrated to be capable of effectively preventing and treating benign prostatic hyperplasia through a mechanism for inhibiting the androgen receptor signaling that induces benign prostatic hyperplasia. Therefore, the Dendropanax morbifera extract and the compound isolated from the extract according to the present invention can be effectively used in the production of medicines and functional foods capable of preventing, treating, and reducing the effects of benign prostatic hyperplasia and prostate cancer.

Abstract translation: 提供了Dendropanax morbifera提取物作为预防和治疗良性前列腺增生的药剂的用途，更具体地，涉及用于预防和治疗良性前列腺增生的组合物和用于预防和减少良性前列腺增生的作用的功能性保健食品，其中 组合物和食品包括作为活性成分的Dendropanax morbifera提取物或从提取物中分离然后纯化的化合物。 已经证明了Dendropanax morbifera提取物和从提取物中分离的化合物能够通过抑制诱导良性前列腺增生的雄激素受体信号传导的机制来有效预防和治疗良性前列腺增生。 因此，根据本发明的提取物中分离的落叶松提取物和化合物可以有效地用于生产能够预防，治疗和降低良性前列腺增生和前列腺癌的作用的药物和功能性食品。