公开(公告)号：US20200254057A1

公开(公告)日：2020-08-13

申请号：US16648043

申请日：2018-09-07

Applicant: INDUSTRY-ACADEMIC COOPERATION FOUNDATION, CHOSUN UNIVERSITY

Inventor： Yoonkyung PARK ,  Jong-Kook LEE

IPC: A61K38/17 ,  A23K20/195 ,  A23K20/147 ,  A23L3/3463 ,  A61K8/64 ,  A01N33/08

Abstract: A method for treating a microorganism or inflammation caused by the microorganism includes administering or applying a composition comprising an antimicrobial peptide with the amino acid sequence of SEQ ID NO: 1 to a subject in need thereof. Because the antimicrobial peptide with the amino acid sequence of SEQ ID NO: 1 exhibits an excellent antimicrobial activity against Gram-negative bacteria and Gram-positive bacteria and also low cytotoxicity for human erythrocytes, it can be advantageously used for various applications.

公开(公告)号：US20190038714A1

公开(公告)日：2019-02-07

申请号：US15757689

申请日：2016-09-12

Applicant: INDUSTRY-ACADEMIC COOPERATION FOUNDATION, CHOSUN UNIVERSITY

Inventor： Yoonkyung PARK ,  Jong-Kook LEE

IPC: A61K38/17 ,  A61P31/04 ,  A61P29/00 ,  A23L33/18

Abstract: An anti-inflammatory composition includes a clavaspirin peptide analogue as an effective ingredient. CSP-4 peptide as a synthetic peptide produced by substituting the 9th and 12th amino acids of clavaspirin peptide originating from stalked sea squirt (Styela clava) with positively charged lysine (K) has an excellent anti-inflammatory effect against an animal model with inflammation response that is caused by antibiotics-resistant bacteria, and exhibits almost no cytotoxicity. Thus, CSP-4 peptide as a clavaspirin peptide analogue of the present invention can be advantageously used as an effective ingredient of a pharmaceutical composition, a cosmetic composition, a food additive, or the like for preventing or treating an inflammatory disorder.