公开(公告)号：US20240117042A1

公开(公告)日：2024-04-11

申请号：US18285668

申请日：2022-04-04

Applicant: INNATE PHARMA

Inventor： BENJAMIN ROSSI ,  STÉPHANIE CHANTEUX ,  ROMAIN REMARK ,  CÉCILE BONNAFOUS ,  CLARENCE DEFFAUD ,  THIBAUT PELAT

IPC: C07K16/28

CPC classification number: C07K16/2803 ,  C07K2317/622

Abstract: The present invention relates to antibodies and methods for detecting KIR3DL2 expression in paraffin-embedded tissue samples. Also provide are methods of making antibodies, antibody fragments, and derivatives thereof that specifically bind to their target antigen in paraffin-embedded tissue samples.

公开(公告)号：US20250092130A1

公开(公告)日：2025-03-20

申请号：US18823932

申请日：2024-09-04

Applicant: INNATE PHARMA

Inventor： CÉCILE BONNAFOUS ,  HÉLÈNE SICARD ,  RENAUD BUFFET

IPC: C07K16/28 ,  A61K39/00 ,  C07K16/30 ,  G01N33/574

Abstract: The present invention relates to methods for the treatment, prevention and diagnosis of peripheral T cell lymphoma using compounds that specifically bind KIR3DL2. The invention also relates to use of antibodies that specifically bind KIR3DL2 in diagnostic and theranostic assays in the detection and treatment of peripheral T cell lymphoma.

公开(公告)号：US20190315857A1

公开(公告)日：2019-10-17

申请号：US16451051

申请日：2019-06-25

Applicant: INNATE PHARMA

Inventor： CÉCILE BONNAFOUS ,  HÉLÈNE SICARD ,  RENAUD BUFFET ,  MATHIEU BLERY

IPC: C07K16/28 ,  C07K16/30 ,  G01N33/574

Abstract: The present disclosure relates to methods for the treatment, prevention and diagnosis of peripheral T-cell lymphoma using compounds that specifically bind NKp46. Included in particular are compounds that bind NKp46 and deplete tumor cells that express NKp46 at their surface, and pharmaceutical compositions comprising the same. The disclosure also relates to the use of antibodies that specifically bind NKp46 in diagnostic and theranostic assays in the detection and treatment of peripheral T-cell lymphoma.

公开(公告)号：US20160002345A1

公开(公告)日：2016-01-07

申请号：US14769158

申请日：2014-02-20

Applicant: INNATE PHARMA

Inventor： CÉCILE BONNAFOUS ,  HÉLÈNE SICARD ,  RENAUD BUFFET

IPC: C07K16/30 ,  G01N33/574

CPC classification number: C07K16/2803 ,  A61K2039/505 ,  C07K16/3023 ,  C07K16/3061 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/732 ,  G01N33/57426 ,  G01N2333/705 ,  G01N2333/70503

Abstract: The present disclosure relates to methods for the treatment, prevention and diagnostic of peripheral T cell lymphoma using compounds that specifically bind KIR3DL2. The disclosure also relates to use of antibodies that specifically bind KIR3DL2 in diagnostic and theranostic assays in the detection and treatment of peripheral T cell lymphoma.

Abstract translation: 本公开涉及使用特异性结合KIR3DL2的化合物治疗，预防和诊断外周T细胞淋巴瘤的方法。 本公开还涉及在诊断和鉴定测定中特异性结合KIR3DL2的抗体在检测和治疗外周T细胞淋巴瘤中的用途。

公开(公告)号：US20240425586A1

公开(公告)日：2024-12-26

申请号：US18731443

申请日：2024-06-03

Applicant: INNATE PHARMA

Inventor： CÉCILE BONNAFOUS ,  HÉLÈNE SICARD ,  RENAUD BUFFET ,  MATHIEU BLERY

IPC: C07K16/28 ,  C07K16/30 ,  G01N33/574

Abstract: The present disclosure relates to methods for the treatment, prevention and diagnosis of peripheral T-cell lymphoma using compounds that specifically bind NKp46. Included in particular are compounds that bind NKp46 and deplete tumor cells that express NKp46 at their surface, and pharmaceutical compositions comprising the same. The disclosure also relates to the use of antibodies that specifically bind NKp46 in diagnostic and theranostic assays in the detection and treatment of peripheral T-cell lymphoma.

公开(公告)号：US20210363248A1

公开(公告)日：2021-11-25

申请号：US17388052

申请日：2021-07-29

Applicant: INNATE PHARMA

Inventor： CÉCILE BONNAFOUS ,  HÉLÈNE SICARD ,  RENAUD BUFFET

IPC: C07K16/28 ,  C07K16/30 ,  G01N33/574

Abstract: The present invention relates to methods for the treatment, prevention and diagnosis of peripheral T cell lymphoma using compounds that specifically bind KIR3DL2. The invention also relates to use of antibodies that specifically bind KIR3DL2 in diagnostic and theranostic assays in the detection and treatment of peripheral T cell lymphoma.

公开(公告)号：US20150376274A1

公开(公告)日：2015-12-31

申请号：US14767600

申请日：2014-02-13

Applicant: INNATE PHARMA

Inventor： CÉCILE BONNAFOUS ,  HÉLÉNE SICARD ,  RENAUD BUFFET ,  MATHIEU BLERY

IPC: C07K16/28 ,  G01N33/574

CPC classification number: C07K16/28 ,  C07K16/2803 ,  C07K16/3061 ,  C07K2317/73 ,  C07K2317/732 ,  G01N33/57407 ,  G01N2333/70503

Abstract: The present disclosure relates to methods for the treatment, prevention and diagnostic of peripheral T cell lymphoma using compounds that specifically bind NKp46. Included in particular are compounds that bind NKp46 and deplete tumor cells that express at their surface NKp46, and pharmaceutical compositions comprising the same. The disclosure also relates to use of antibodies that specifically bind NKp46 in diagnostic and theranostic assays in the detection and treatment of peripheral T cell lymphoma.

Abstract translation: 本公开涉及使用特异性结合NKp46的化合物治疗，预防和诊断外周T细胞淋巴瘤的方法。 特别包括结合NKp46并消耗在其表面NKp46表达的肿瘤细胞的化合物和包含其的药物组合物。 本公开还涉及在诊断和鉴定测定中特异性结合NKp46的抗体在检测和治疗外周T细胞淋巴瘤中的用途。