公开(公告)号：US12013322B2

公开(公告)日：2024-06-18

申请号：US17194169

申请日：2021-03-05

Applicant: INNOVAPREP LLC

Inventor： Andew Edward Page ,  Zachary A. Packingham ,  David Scott Alburty ,  Alec D. Adolphson

IPC: G01N1/40 ,  B01L3/02 ,  C12Q1/24

CPC classification number: G01N1/4077 ,  B01L3/0275 ,  C12Q1/24 ,  B01L2200/026 ,  B01L2200/0631 ,  B01L2300/0681 ,  B01L2300/161 ,  G01N2001/4088

Abstract: Highly efficient and rapid filtration-based concentration devices, systems and methods are disclosed with sample fluidic lines and a filter packaged in a disposable tip which concentrate biological particles that are suspended in liquid from a dilute feed suspension. A sample concentrate or retentate suspension is retained while eliminating the separated fluid in a separate flow stream. The concentrate is then dispensed from the disposable tip in a set volume of elution fluid. Suspended biological particles include such materials as proteins/toxins, viruses, DNA, and/or bacteria in the size range of approximately 0.001 micron to 20 microns diameter. Concentration of these particles is advantageous for detection of target particles in a dilute suspension, because concentrating them into a small volume makes them easier to detect. All conduits by which the disposable tip attaches to the instrument are combined into a single connection point on the upper end of the tip.

公开(公告)号：US20210215583A1

公开(公告)日：2021-07-15

申请号：US17194169

申请日：2021-03-05

Applicant: INNOVAPREP LLC

Inventor： Andew Edward Page ,  Zachary A. Packingham ,  David Scott Alburty ,  Alec D. Adolphson

IPC: G01N1/40 ,  B01L3/02 ,  C12Q1/24

Abstract: Highly efficient and rapid filtration-based concentration devices, systems and methods are disclosed with sample fluidic lines and a filter packaged in a disposable tip which concentrate biological particles that are suspended in liquid from a dilute feed suspension. A sample concentrate or retentate suspension is retained while eliminating the separated fluid in a separate flow stream. The concentrate is then dispensed from the disposable tip in a set volume of elution fluid. Suspended biological particles include such materials as proteins/toxins, viruses, DNA, and/or bacteria in the size range of approximately 0.001 micron to 20 microns diameter. Concentration of these particles is advantageous for detection of target particles in a dilute suspension, because concentrating them into a small volume makes them easier to detect. All conduits by which the disposable tip attaches to the instrument are combined into a single connection point on the upper end of the tip.