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公开(公告)号：US20240385089A1
公开(公告)日：2024-11-21
申请号：US18789567
申请日：2024-07-30
Applicant: INNOVAPREP LLC
Inventor： Alec D. Adolphson , Andrew E. Page , John D. Birkenholz , David Goad
Abstract: Devices, systems and methods are disclosed which relate to a prefiltration device that can be used with the concentrating pipette instruments and other devices which draw a sample in through one opening and dispense a concentrated or eluted sample out through the same opening. The device allows the sample to be passed through a prefilter when entering the opening and then bypassed the prefilter when being dispensed through the same opening.
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公开(公告)号：US12013322B2
公开(公告)日：2024-06-18
申请号：US17194169
申请日：2021-03-05
Applicant: INNOVAPREP LLC
Inventor： Andew Edward Page , Zachary A. Packingham , David Scott Alburty , Alec D. Adolphson
CPC classification number: G01N1/4077 , B01L3/0275 , C12Q1/24 , B01L2200/026 , B01L2200/0631 , B01L2300/0681 , B01L2300/161 , G01N2001/4088
Abstract: Highly efficient and rapid filtration-based concentration devices, systems and methods are disclosed with sample fluidic lines and a filter packaged in a disposable tip which concentrate biological particles that are suspended in liquid from a dilute feed suspension. A sample concentrate or retentate suspension is retained while eliminating the separated fluid in a separate flow stream. The concentrate is then dispensed from the disposable tip in a set volume of elution fluid. Suspended biological particles include such materials as proteins/toxins, viruses, DNA, and/or bacteria in the size range of approximately 0.001 micron to 20 microns diameter. Concentration of these particles is advantageous for detection of target particles in a dilute suspension, because concentrating them into a small volume makes them easier to detect. All conduits by which the disposable tip attaches to the instrument are combined into a single connection point on the upper end of the tip.
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3.发明公开公开(公告)号：US20240139724A1
公开(公告)日：2024-05-02
申请号：US18384345
申请日：2023-10-26
Applicant: INNOVAPREP LLC
Inventor： Andrew E. Page , David Goad , Steven D. Graham
CPC classification number: B01L3/0217 , A61M5/31565 , B01L3/0275 , G01N35/1004 , B01L2300/0681 , B01L2400/0487 , B01L2400/0622 , B01L2400/0644 , G01N2035/1006
Abstract: Highly efficient and rapid filtration-based concentration devices, systems and methods are disclosed with a rotary distribution valve connected to a syringe pump which maintains control and flow of various fluids to a sample through a retentate port.
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公开(公告)号：US11698328B2
公开(公告)日：2023-07-11
申请号：US16934931
申请日：2020-07-21
Applicant: InnovaPrep LLC
Inventor： Andrew Edward Page , David Scott Alburty , Alec D. Adolphson , Pamela S. Murowchick , Zachary A. Packingham
CPC classification number: G01N1/4077 , B01D46/0032 , B01D46/543 , B01D46/70 , G01N1/2205 , G01N2001/4088
Abstract: Devices, systems and methods are disclosed which relate to using a wet foam elution method for removal of particles from a flat filter. Particles are captured from the atmosphere onto the flat filter. The flat filter is then placed into an extractor which passes a stream of wet foam through the flat filter. Expansion of the foam works to efficiently remove captured particles. The foam flows from the filter along with the captured particles into a sample container. Once in the sample container, the foam quickly breaks down leaving an analysis ready liquid sample.
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公开(公告)号：US20210208032A1
公开(公告)日：2021-07-08
申请号：US17209434
申请日：2021-03-23
Applicant: InnovaPrep LLC
Inventor： Andrew Edward Page , Zachary A. Packingham , David Scott Alburty , Alec D. Adolphson
Abstract: Highly efficient and rapid filtration-based concentration devices, systems and methods are disclosed with sample fluidic lines and a filter packaged in a disposable tip which concentrate biological particles that are suspended in liquid from a dilute feed suspension. A sample concentrate or retentate suspension is retained while eliminating the separated fluid in a separate flow stream. The concentrate is then dispensed from the disposable tip in a set volume of elution fluid. Suspended biological particles include such materials as proteins/toxins, viruses, DNA, and/or bacteria in the size range of approximately 0.001 micron to 20 microns diameter. Concentration of these particles is advantageous for detection of target particles in a dilute suspension, because concentrating them into a small volume makes them easier to detect. A single-use pipette tip includes fluid ports for aspirating the sample and connecting to a concentrating unit.
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Patent Agency Ranking
公开(公告)号：US20200348217A1
公开(公告)日：2020-11-05
申请号：US16934931
申请日：2020-07-21
Applicant: InnovaPrep LLC
Inventor： Andrew Edward Page , David Scott Alburty , Alec D. Adolphson , Pamela S. Murowchick , Zachary A. Packingham
Abstract: Devices, systems and methods are disclosed which relate to using a wet foam elution method for removal of particles from a flat filter. Particles are captured from the atmosphere onto the flat filter. The flat filter is then placed into an extractor which passes a stream of wet foam through the flat filter. Expansion of the foam works to efficiently remove captured particles. The foam flows from the filter along with the captured particles into a sample container. Once in the sample container, the foam quickly breaks down leaving an analysis ready liquid sample.
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公开(公告)号：US10718696B2
公开(公告)日：2020-07-21
申请号：US15397524
申请日：2017-01-03
Applicant: InnovaPrep LLC
Inventor： Andrew Edward Page , David Scott Alburty , Alec D. Adolphson , Pamela S. Murowchick , Zachary A. Packingham
Abstract: Devices, systems and methods are disclosed which relate to using a wet foam elution method for removal of particles from a flat filter. Particles are captured from the atmosphere onto the flat filter. The flat filter is then placed into an extractor which passes a stream of wet foam through the flat filter. Expansion of the foam works to efficiently remove captured particles. The foam flows from the filter along with the captured particles into a sample container. Once in the sample container, the foam quickly breaks down leaving an analysis ready liquid sample.
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公开(公告)号：US20250025834A1
公开(公告)日：2025-01-23
申请号：US18778834
申请日：2024-07-19
Applicant: INNOVAPREP LLC
Inventor： Andrew E. Page , David Goad , David S. Alburty
IPC: B01D61/14
Abstract: Highly efficient and rapid filtration-based methods for isolation and concentration of exosomes and extracellular vesicles from biological fluids, including urine, which utilize pretreatment, prefiltration, wash steps and isolation and concentration using the concentrating pipette are disclosed.
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公开(公告)号：US20220397494A1
公开(公告)日：2022-12-15
申请号：US17841563
申请日：2022-06-15
Applicant: Boehringer Ingelheim Vetmedica GmbH , INNOVAPREP LLC
Inventor： Zachary A. Packingham , Steven D. Graham , Sidney J. Spry , Dale D. Polson
Abstract: The present subject disclosure discloses devices, systems, and methods related to collection and recovery of Aerosols and Bioaerosols for analysis. The system includes an omni-directional inlet assembly that is easily removed for decontamination and can be replaced with an already clean inlet assembly or with directional inlets or other tools for collection from animal breathing zones, air ducts, air nearing moving vehicles and other sampling scenarios. Further, the system includes other features that enable the device to be lower in cost than other similar systems while providing improved usability and performance.
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公开(公告)号：US10955316B2
公开(公告)日：2021-03-23
申请号：US15431655
申请日：2017-02-13
Applicant: InnovaPrep LLC
Inventor： Andrew Edward Page , Zachary A. Packingham , David Scott Alburty , Alec D. Adolphson
Abstract: Highly efficient and rapid filtration-based concentration devices, systems and methods are disclosed with sample fluidic lines and a filter packaged in a disposable tip which concentrate biological particles that are suspended in liquid from a dilute feed suspension. A sample concentrate or retentate suspension is retained while eliminating the separated fluid in a separate flow stream. The concentrate is then dispensed from the disposable tip in a set volume of elution fluid. Suspended biological particles include such materials as proteins/toxins, viruses, DNA, and/or bacteria in the size range of approximately 0.001 micron to 20 microns diameter. Concentration of these particles is advantageous for detection of target particles in a dilute suspension, because concentrating them into a small volume makes them easier to detect. A single-use pipette tip includes fluid ports for aspirating the sample and connecting to a concentrating unit.
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