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1.发明申请公开(公告)号：US20180344807A1
公开(公告)日：2018-12-06
申请号：US16048397
申请日：2018-07-30
申请人： INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , INSTITUT PASTEUR DE LILLE , UNIVERSITÉ DE LILLE 1 SCIENCES ET TECHNOLOGIES , UNIVERSITÉ DE DROIT ET DE LA SANTÉ DE LILLE 2
CPC分类号： A61K38/164 , A61K45/06
摘要： The present invention relates to methods and pharmaceutical compositions for the treatment of acute exacerbation of chronic obstructive pulmonary disease. In particular, the present invention relates to a method of treating acute exacerbation of chronic obstructive pulmonary disease in a subject in need thereof comprising administering the subject with a therapeutically effective amount of a flagellin polypeptide.
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2.发明申请公开(公告)号：US20180264077A1
公开(公告)日：2018-09-20
申请号：US15537596
申请日：2015-12-22
申请人： INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) , CENTRE NATIONAL DE LA RECHERCHE SACIENTIFIQUE (CNRS) , UNIVERSITÉ DE DROIT ET DE LA SANTÉ DE LILLE 2 , UNIVERSITÉ DE LILLE 1 SCIENCES ET TECHNOLOGIES , INSTITUT PASTEUR DE LILLE
摘要： The present invention relates to methods and pharmaceutical compositions for the treatment of bacterial superinfections post-influenza. In particular, the present invention relates to a method of treating a bacterial superinfection post-influenza in a subject in need thereof comprising administering the subject with a therapeutically effective amount of a flagellin polypeptide optionally in combination with at least one antibiotic.
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3.发明申请公开(公告)号：US20170354709A1
公开(公告)日：2017-12-14
申请号：US15539380
申请日：2015-12-23
申请人： INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , INSTITUT PASTEUR DE LILLE , UNIVERSITÉ DE LILLE 1 SCIENCES ET TECHNOLOGIES , UNIVERSITÉ DE DROIT ET DE LA SANTÉ DE LILLE 2
CPC分类号： A61K38/164 , A61K45/06
摘要： The present invention relates to methods and pharmaceutical compositions for the treatment of acute exacerbation of chronic obstructive pulmonary disease. In particular, the present invention relates to a method of treating acute exacerbation of chronic obstructive pulmonary disease in a subject in need thereof comprising administering the subject with a therapeutically effective amount of a flagellin polypeptide.
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4.发明申请METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF BACTERIAL INFECTIONS 有权用于治疗细菌感染的方法和药物组合物公开(公告)号：US20160151453A1
公开(公告)日：2016-06-02
申请号：US14906747
申请日：2014-07-25
申请人： INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) , UNIVERSITÉ DE DROIT ET DE LA SANTÉ DE LILLE 2 , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , INSTITUT PASTEUR DE LILLE , UNIVERSITÉ DE LILLE 1 SCIENCES ET TECHNOLOGIES , ETH ZURICH , UNIVERSIDAD DE LA REPUBLICA
发明人： Wolf-Dietrich HARDT , Patrick KAISER , Jean-Claude SIRARD , Christophe CARNOY , Delphine FOUGERON , Jose Alejandro CHABALGOITY , Natalia MUNOZ
IPC分类号： A61K38/16 , A61K31/505 , A61K31/42 , A61K31/43
CPC分类号： A61K38/164 , A61K31/42 , A61K31/43 , A61K31/505 , A61K31/635 , A61K45/06 , Y02A50/402 , Y02A50/475 , Y02A50/481 , A61K2300/00
摘要： The present invention relates to methods and pharmaceutical compositions for the treatment of bacterial infections. In particular, the present invention relates to a Toll-like receptor (TLR) agonist for use in a method for the treatment of a bacterial infection in a subject in need thereof wherein the TLR agonist is administered to the subject in combination with at least one antibiotic.
摘要翻译： 本发明涉及用于治疗细菌感染的方法和药物组合物。 特别地，本发明涉及用于治疗有需要的受试者的细菌感染的方法中的Toll样受体（TLR）激动剂，其中将TLR激动剂与至少一种 抗生素。
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公开(公告)号：US20240277801A1
公开(公告)日：2024-08-22
申请号：US18569392
申请日：2022-06-30
申请人： INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , UNIVERSITÉ DE TOURS FRANÇOIS RABELAIS , UNIVERSITÉ DE LILLE , INSTITUT PASTEUR DE LILLE , CENTRE HOSPITALIER REGIONAL UNIVERSITAIRE DE LILLE
CPC分类号： A61K38/164 , A61K9/0078 , A61K47/02 , A61K47/12 , A61K47/26
摘要： The present invention arises from a formulation study in order to define the best excipients including buffer, surfactant, sugar and amino acid to stabilize Flagellin during mesh-nebulization. One of the key factors in stabilising proteins is determining the optimal pH and buffer system to provide adequate solubility and stability and avoid aggregate formation during the aerosolization process. Different formulation have been assayed in order to obtain a stable and soluble aerosol composition comprising flagellin polypeptide in particular considering the choice of the buffering agent, the surfactant and the pH of the liquid formulation comprising the flagellin polypeptide in order to maintain the activity of the flagellin after the aerosolization process. Accordingly, the present invention relates to an aerosol composition comprising droplets comprising a liquid formulation, wherein the liquid formulation comprises a flagellin polypeptide, a buffer (acetate and/or phosphate) and a surfactant (polysorbate). The aerosol composition of the present invention is suitable for the treatment of lung bacterial infections.
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