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公开(公告)号：US10736937B2
公开(公告)日：2020-08-11
申请号：US15537596
申请日：2015-12-22
申请人： INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , UNIVERSITÉ DE DROIT ET DE LA SANTÉ DE LILLE 2 , UNIVERSITÉ DE LILLE 1 SCIENCES ET TECHNOLOGIES , INSTITUT PASTEUR DE LILLE
摘要： The present invention relates to methods and pharmaceutical compositions for the treatment of bacterial superinfections post-influenza. In particular, the present invention relates to a method of treating a bacterial superinfection post-influenza in a subject in need thereof comprising administering the subject with a therapeutically effective amount of a flagellin polypeptide optionally in combination with at least one antibiotic.
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2.发明申请公开(公告)号：US20170354709A1
公开(公告)日：2017-12-14
申请号：US15539380
申请日：2015-12-23
申请人： INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , INSTITUT PASTEUR DE LILLE , UNIVERSITÉ DE LILLE 1 SCIENCES ET TECHNOLOGIES , UNIVERSITÉ DE DROIT ET DE LA SANTÉ DE LILLE 2
CPC分类号： A61K38/164 , A61K45/06
摘要： The present invention relates to methods and pharmaceutical compositions for the treatment of acute exacerbation of chronic obstructive pulmonary disease. In particular, the present invention relates to a method of treating acute exacerbation of chronic obstructive pulmonary disease in a subject in need thereof comprising administering the subject with a therapeutically effective amount of a flagellin polypeptide.
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3.发明申请公开(公告)号：US20170182077A1
公开(公告)日：2017-06-29
申请号：US15118260
申请日：2015-02-13
申请人： INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) , INSTITUT PASTEUR DE LILLE , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , UNIVERSITÉ DE LILLE 1 SCIENCES ET TECHNOLOGIES , UNIVERSITÉ DE DROIT ET DE LA SANTÉ DE LILLE 2
发明人： Philippe GOSSET , Muriel PICHAVANT , Gaëlle REMY
IPC分类号： A61K31/7032 , A61K39/09 , A61K39/102 , C07K16/28 , A61K45/06
CPC分类号： A61K31/7032 , A61K39/092 , A61K39/102 , A61K45/06 , A61K2039/505 , C07K16/2809 , C07K2317/52 , C07K2317/75 , Y02A50/478
摘要： The present invention relates to methods and pharmaceutical compositions for the treatment of acute exacerbation of chronic obstructive pulmonary disease. In particular, the present invention relates to a method of treating acute exacerbation of chronic obstructive pulmonary disease in a subject in need thereof comprising administering the subject with a therapeutically effective amount of at least one NKT cell agonist.
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4.发明申请METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF BACTERIAL INFECTIONS 有权用于治疗细菌感染的方法和药物组合物公开(公告)号：US20160151453A1
公开(公告)日：2016-06-02
申请号：US14906747
申请日：2014-07-25
申请人： INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) , UNIVERSITÉ DE DROIT ET DE LA SANTÉ DE LILLE 2 , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , INSTITUT PASTEUR DE LILLE , UNIVERSITÉ DE LILLE 1 SCIENCES ET TECHNOLOGIES , ETH ZURICH , UNIVERSIDAD DE LA REPUBLICA
发明人： Wolf-Dietrich HARDT , Patrick KAISER , Jean-Claude SIRARD , Christophe CARNOY , Delphine FOUGERON , Jose Alejandro CHABALGOITY , Natalia MUNOZ
IPC分类号： A61K38/16 , A61K31/505 , A61K31/42 , A61K31/43
CPC分类号： A61K38/164 , A61K31/42 , A61K31/43 , A61K31/505 , A61K31/635 , A61K45/06 , Y02A50/402 , Y02A50/475 , Y02A50/481 , A61K2300/00
摘要： The present invention relates to methods and pharmaceutical compositions for the treatment of bacterial infections. In particular, the present invention relates to a Toll-like receptor (TLR) agonist for use in a method for the treatment of a bacterial infection in a subject in need thereof wherein the TLR agonist is administered to the subject in combination with at least one antibiotic.
摘要翻译： 本发明涉及用于治疗细菌感染的方法和药物组合物。 特别地，本发明涉及用于治疗有需要的受试者的细菌感染的方法中的Toll样受体（TLR）激动剂，其中将TLR激动剂与至少一种 抗生素。
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5.发明申请公开(公告)号：US20190144539A1
公开(公告)日：2019-05-16
申请号：US16303391
申请日：2017-05-24
申请人： INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , INSTITUT PASTEUR DE LILLE , UNIVERSITÉ DE LILLE 1 SCIENCES ET TECHNOLOGIES , UNIVERSITÉ DE DROIT ET DE LA SANTÉ DE LILLE 2
IPC分类号： C07K16/28 , C07K16/24 , A61P31/04 , C12N15/115 , A61K45/06
摘要： The present invention relates to methods and pharmaceutical compositions for the treatment of pulmonary bacterial infections. The increasing burden of antimicrobial resistance coupled with the decreasing number of antibiotics in development has urged for strategies to elaborate new therapies. The inventors showed a therapeutic effect of IL-20 receptor 10 antagonists in pulmonary bacterial infection mouse model. Indeed, they demonstrated that treatment with IL-20 receptor antagonists reduces bacterial burden, cellular infiltration and inflammation in bronchoalveolar lavage fluid (BALF) and lung. In particular, the present invention relates to an antagonist of IL-20 cytokines, or/and an antagonist of IL-20RB receptor for use in a method for the treatment of pulmonary bacterial infections in a subject in 15 need thereof.
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6.发明申请公开(公告)号：US20180344807A1
公开(公告)日：2018-12-06
申请号：US16048397
申请日：2018-07-30
申请人： INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , INSTITUT PASTEUR DE LILLE , UNIVERSITÉ DE LILLE 1 SCIENCES ET TECHNOLOGIES , UNIVERSITÉ DE DROIT ET DE LA SANTÉ DE LILLE 2
CPC分类号： A61K38/164 , A61K45/06
摘要： The present invention relates to methods and pharmaceutical compositions for the treatment of acute exacerbation of chronic obstructive pulmonary disease. In particular, the present invention relates to a method of treating acute exacerbation of chronic obstructive pulmonary disease in a subject in need thereof comprising administering the subject with a therapeutically effective amount of a flagellin polypeptide.
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7.发明申请公开(公告)号：US20160166646A1
公开(公告)日：2016-06-16
申请号：US14900204
申请日：2014-06-27
申请人： INSERM (Institute National de la Santé et de la Recherche Médicale) , INSTITUTE PASTEUR DE LILLE , CENTRE NATIONAL DE LA RECHERCHE SCIENTFIQUE (CNRS) , Université de Lille 1 Sciences et Technologies , Université de Droit et de la Santé de Lille 2
发明人： Philippe GOSSET , Muriel PICHAVANT , Riti SHARAN
CPC分类号： A61K38/20 , A61K9/007 , A61K39/092 , A61K45/06 , A61K48/00 , A61K2039/521 , Y02A50/473 , Y02A50/478
摘要： The present invention relates to methods and pharmaceutical compositions for the treatment of acute exacerbation of chronic obstructive pulmonary disease. In particular, the invention relates to relates to a polypeptide selected from the group consisting of IL-22 polypeptides or IL-17 polypeptides for use in a method for the treatment of acute exacerbation of chronic obstructive pulmonary disease in a subject in need thereof.
摘要翻译： 本发明涉及治疗慢性阻塞性肺疾病急性加重的方法和药物组合物。 特别地，本发明涉及用于治疗有需要的受试者的慢性阻塞性肺疾病急性加重的方法中的IL-22多肽或IL-17多肽的多肽。
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8.发明授权公开(公告)号：US10954299B2
公开(公告)日：2021-03-23
申请号：US16303391
申请日：2017-05-24
申请人： INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , INSTITUT PASTEUR DE LILLE , UNIVERSITÉ DE LILLE 1 SCIENCES ET TECHNOLOGIES , UNIVERSITÉ DE DROIT ET DE LA SANTÉ DE LILLE 2
摘要： The present invention relates to methods and pharmaceutical compositions for the treatment of pulmonary bacterial infections. The increasing burden of antimicrobial resistance coupled with the decreasing number of antibiotics in development has urged for strategies to elaborate new therapies. The inventors showed a therapeutic effect of IL-20 receptor 10 antagonists in pulmonary bacterial infection mouse model. Indeed, they demonstrated that treatment with IL-20 receptor antagonists reduces bacterial burden, cellular infiltration and inflammation in bronchoalveolar lavage fluid (BALF) and lung. In particular, the present invention relates to an antagonist of IL-20 cytokines, or/and an antagonist of IL-20RB receptor for use in a method for the treatment of pulmonary bacterial infections in a subject in 15 need thereof.
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9.发明申请公开(公告)号：US20180264077A1
公开(公告)日：2018-09-20
申请号：US15537596
申请日：2015-12-22
申请人： INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) , CENTRE NATIONAL DE LA RECHERCHE SACIENTIFIQUE (CNRS) , UNIVERSITÉ DE DROIT ET DE LA SANTÉ DE LILLE 2 , UNIVERSITÉ DE LILLE 1 SCIENCES ET TECHNOLOGIES , INSTITUT PASTEUR DE LILLE
摘要： The present invention relates to methods and pharmaceutical compositions for the treatment of bacterial superinfections post-influenza. In particular, the present invention relates to a method of treating a bacterial superinfection post-influenza in a subject in need thereof comprising administering the subject with a therapeutically effective amount of a flagellin polypeptide optionally in combination with at least one antibiotic.
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