公开(公告)号：US20180207250A1

公开(公告)日：2018-07-26

申请号：US15745273

申请日：2016-07-13

申请人： INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) ,  UNIVERSITE PARIS DESCARTES ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) ,  UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6) ,  UNIVERSITE PARIS DIDEROT - PARIS 7 ,  UNIVERSITÉ PARIS-SUD ,  SORBONNE UNIVERSITE

发明人： Roberto MALLONE ,  Slobodan CULINA ,  Nimesh GUPTA ,  Sebastien LACROIX-DESMAZES

IPC分类号： A61K39/00 ,  A61P37/06

CPC分类号： A61K39/0008 ,  A61K2039/542 ,  A61K2039/577 ,  A61K2039/6056 ,  A61P37/06

摘要： The present invention relates to methods and pharmaceutical compositions of inducing immune tolerance by mucosal vaccination with Fc-coupled antigens. In particular, the present invention relates to a method for inducing tolerance to one antigen of interest in a subject in need thereof, comprising the mucosal administration to the subject of a therapeutically effective amount of a recombinant chimeric construct comprising a FcRn targeting moiety and an antigen-containing moiety.

公开(公告)号：US20220175896A1

公开(公告)日：2022-06-09

申请号：US17555761

申请日：2021-12-20

申请人： INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) ,  UNIVERSITE PARIS DESCARTES ,  UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6) ,  UNIVERSITE PARIS DIDEROT - PARIS 7

发明人： Roberto MALLONE ,  Slobodan CULINA ,  Nimesh GUPTA ,  Sebastien LACROIX-DESMAZES

IPC分类号： A61K39/00 ,  A61P37/06

摘要： The present invention relates to methods and pharmaceutical compositions of inducing immune tolerance by mucosal vaccination with Fc-coupled antigens. In particular, the present invention relates to a method for inducing tolerance to one antigen of interest in a subject in need thereof, comprising the mucosal administration to the subject of a therapeutically effective amount of a recombinant chimeric construct comprising a FcRn targeting moiety and an antigen-containing moiety.

公开(公告)号：US20200155658A1

公开(公告)日：2020-05-21

申请号：US16681910

申请日：2019-11-13

申请人： INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) ,  UNIVERSITE PARIS DESCARTES ,  UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6) ,  UNIVERSITE PARIS DIDEROT - PARIS 7

发明人： Roberto MALLONE ,  Slobodan CULINA ,  Nimesh GUPTA ,  Sebastien LACROIX-DESMAZES

IPC分类号： A61K39/00 ,  A61P37/06

摘要： The present invention relates to methods and pharmaceutical compositions of inducing immune tolerance by mucosal vaccination with Fc-coupled antigens. In particular, the present invention relates to a method for inducing tolerance to one antigen of interest in a subject in need thereof, comprising the mucosal administration to the subject of a therapeutically effective amount of a recombinant chimeric construct comprising a FcRn targeting moiety and an antigen-containing moiety.