公开(公告)号：US11487094B2

公开(公告)日：2022-11-01

申请号：US16603216

申请日：2018-04-06

申请人： UNIVERSITE PARIS DESCARTES ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

发明人： Emiliano Ronzitti ,  Nicolò Accanto ,  Valentina Emiliani ,  Eirini Papagiakoumou ,  Dimitrii Tanese

IPC分类号： G02B21/06 ,  G02B5/32 ,  G02B27/10 ,  G03F7/20

摘要： The present invention concerns an optical system for spatiotemporally shaping the wavefront of the electric field of a light beam (1) to be projected into a target volume (5), where the propagation axis is axis z, to create 3D patterned illumination in the target volume (5), comprising a pulsed laser source, configured to have an illumination pattern whose transversal surface at the target volume being superior to the diffraction limit of the optical system, at least one intermediate optical element (4) which is a dispersive grating for performing temporal focusing of the light beam (1), located, on the propagation axis (z), where an image of the illumination pattern is formed, for modulating the phase and/or the amplitude of the electric field of the light beam, and a second optical element (3) which is a spatiallight modulator for modulating the phase of the electric field of the input light beam, and for realizing spatiotemporal multiplexing to create 3D patterned illumination in the target volume (5) by replicating the illumination pattern, so as to have several replicated illumination patterns in the target volume (5), and controlling the position with transversal coordinates X, Y and axial coordinate Z of each replicated illumination pattern in the target volume (5).

公开(公告)号：US20220090127A1

公开(公告)日：2022-03-24

申请号：US16618251

申请日：2018-06-01

申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM ,  UNIVERSITE PARIS DESCARTES ,  ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS ,  MAGINE - INSTITUT DES MALADIES GENETIQUES NECKER ENFANTS MALADES

发明人： Annarita MICCIO ,  Vasco MENEGHINI

IPC分类号： C12N15/86 ,  C12N15/11 ,  C12N15/90 ,  C12N9/22 ,  A61K35/28 ,  A61P7/00 ,  A61K31/713 ,  A61K38/46

摘要： This invention relates to recombinant viral vectors, preferably retroviral (RV), lentiviral (LV) or adeno-associated viral (AAV) vectors, compositions thereof, the use of the recombinant viral vectors or the compositions thereof, kits of parts comprising said recombinant viral vectors or compositions thereof and a catalytically active Cas9 or Cpf1 protein, methods for modifying the genome of a cell, and the cells obtainable by such methods.

公开(公告)号：US11253172B2

公开(公告)日：2022-02-22

申请号：US16476484

申请日：2018-01-09

申请人： UNIVERSITE PARIS DESCARTES ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  UNIVERSITE PARIS NORD ,  ETAT FRANCAIS—MINISTERE DE LA DEFENSE—DIRECTION CENTRALE DU SERVICE DE SANTE DES ARMEES

发明人： Pierre Vidal ,  Rémi Barrois-Muller ,  Damien Ricard ,  Laurent Oudre

IPC分类号： A61B5/11 ,  A61B5/00 ,  A61B5/389

摘要： A device for analyzing the regularity and symmetry of a sequence of N gait or running cycles of a person, comprising sensors for measuring raw time signals of a physical movement variable of a body segment, a processing unit connected to the sensors for measuring and configured to separate the raw time signals into distinct time signals Ci, the Ci series being associated with a given gait or running cycle i of the person, to calculate at least one similarity coefficient between the signal Ci associated with gait or running cycle i and another signal Cj associated with a gait or running cycle j of the person. A display is configured to display the matrix M(i,j) with each value of the similarity coefficient shown in the matrix M(i,j) in color to form a graduated color scale indicating the similarity between the gait or running cycles i and j.

公开(公告)号：US20200306174A1

公开(公告)日：2020-10-01

申请号：US16852959

申请日：2020-04-20

申请人： ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS ,  INSTITUTE NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) ,  INSTITUT DE RADIOPROTECTION ET DE SURETE NUCLEAIRE ,  Etat Francais - Ministere de la Defense - Direction centrale du service de sante des armees ,  UNIVERSITE PARIS DESCARTES

发明人： Antoine LAFONT ,  Bernard COULOMB ,  Jean-Jacques LATAILLADE ,  Christine LINARD

IPC分类号： A61K8/98 ,  A61Q7/00 ,  A61K35/33 ,  A61K31/58 ,  A61K31/505

摘要： The present invention relates to the use of gingival fibroblast-derived products to reduce hair loss and promote hair growth. Specifically, the invention relates to a product derived from gingival fibroblasts to be used in the treatment or prevention of alopecia, as well as in the promotion of natural hair growth and/or in the control of natural hair loss.

公开(公告)号：US10766873B2

公开(公告)日：2020-09-08

申请号：US16069049

申请日：2017-01-11

申请人： Centre National de la Recherche Scientifique (CNRS) ,  Institut National de la Sante et de la Recherche Medicale (INSERM) ,  Universite Paris Descartes

发明人： Sandrine Bourdoulous ,  Camille Faure

IPC分类号： C07D335/20 ,  A61K31/41 ,  A61K31/497 ,  A61P35/00 ,  C07D275/04 ,  C07D279/24 ,  C07D293/12 ,  C07D405/06 ,  C07D409/06

摘要： The present invention relates to compounds of the following general formula (I) or (II): or a pharmaceutically acceptable salt and/or solvate thereof, for use in the treatment and/or in the prevention of ErbB2 dependent cancers, and pharmaceutical compositions containing such compounds.

公开(公告)号：US20200264165A1

公开(公告)日：2020-08-20

申请号：US16067899

申请日：2017-01-03

申请人： INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LARECHERCHE MEDICALE) ,  UNIVERSITE PARIS DESCARTES ,  ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS (APHP)

发明人： Eric TARTOUR ,  Charles DARIANE ,  Clemence GRANIER ,  Alain GEY

IPC分类号： G01N33/50 ,  G01N33/574 ,  C07K16/28

摘要： The present invention relates to a method for predicting the survival time of a subject suffering from renal cell carcinoma comprising the steps of: i) quantifying the percent of CD8+ T cells co-expressing PD-1 and Tim-3 in a tumor tissue sample obtained from the subject, ii) comparing the percent quantified at step i), with its corresponding predetermined reference value and iii) concluding that the subject will have a short survival time when the percent of CD8+ T cells co-expressing PD-1 and Tim-3 is higher than its corresponding predetermined reference value or concluding that the subject will have a long survival time when the percent of CD8+ T cells co-expressing PD-1 and Tim-3 is lower than its corresponding predetermined reference value.

公开(公告)号：US20200225247A1

公开(公告)日：2020-07-16

申请号：US16495278

申请日：2018-03-20

申请人： INSERM (INSTITUTE NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) ,  UNIVERSITE PARIS DESCARTES ,  ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS (APHP) ,  UNIVERSITE PARIS DIDEROT-PARIS 7

发明人： Pierre-Emmanuel RAUTOU ,  Chantal BOULANGER-ROBERT

IPC分类号： G01N33/68 ,  G01N33/543

摘要： Following a prospective clinical study that includes 242 patients, the inventors show that hepatocyte-derived MV levels predicted transplantation-free survival at 6 months in univariate analysis. In multivariate analysis, this association was shown to be independent of Child-Pugh and of MELD score. Thus the present invention thus relates to a method of predicting the transplantation-free survival time of a patient suffering from cirrhosis comprising determining the level of hepatocyte-derived microvesicles (e.g. by an ELISA assay) in a blood sample obtained from the patient.

公开(公告)号：US20200222418A1

公开(公告)日：2020-07-16

申请号：US16628687

申请日：2018-07-06

申请人： Centre National de la Recherche Scientifique (CNRS) ,  Institute National de la Sante et de la Recherche Medicale (INSERM) ,  Universite Paris Descartes

发明人： Sandrine Bourdoulous ,  Kévin Denis ,  Loïc Le Guennec

IPC分类号： A61K31/5415 ,  A61K9/00 ,  A61K45/06 ,  A61P31/04

摘要： The present invention provides a phenothiazine derivative of formula (I) for use in preventing and/or treating infection caused by bacteria carrying Type IV pili, such as N. meningitidis, and more specifically for use in preventing and/or treating meningitis. The present invention further relates to a composition for the use in preventing and/or treating infection caused by bacteria carrying Type IV pili, such as purpura fulminans and meningitis, comprising a phenothiazine derivative of formula (I) and an antibiotic selected from the group consisting of beta-lactams and aminoglycosides, and/or dexamethasone.

公开(公告)号：US20200163879A1

公开(公告)日：2020-05-28

申请号：US16612061

申请日：2018-05-09

申请人： UNIVERSITE DE BORDEAUX ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  INSTITUT POLYTECHNIQUE DE BORDEAUX ,  ECOLE NATIONALE SUPERIEURE D'ARTS ET METIERS ,  UNIVERSITE PARIS DESCARTES ,  ÉCOLE NATIONALE SUPERIEURE DE CHIMIE DE PARIS - CHIMIE PARISTECH ,  PARIS SCIENCES ET LETTRES (PSL) RESEARCH UNIVERSITY ,  INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE

发明人： VIRGINIE BUSIGNIES-GODDIN ,  PASCAL BIGEY ,  CHRISTINE CHARRUEAU ,  VIRGINIE ESCRIOU ,  PIERRE TCHORELOFF

IPC分类号： A61K9/127 ,  A61K9/20 ,  A61K9/19 ,  A61K31/7088 ,  A61P1/04

摘要： The invention relates to a process for the manufacture of a tablet comprising a nucleic acid vector.

公开(公告)号：US20200051240A1

公开(公告)日：2020-02-13

申请号：US16339615

申请日：2017-10-04

申请人： UNIVERSITE PARIS DESCARTES ,  INTRASENSE ,  ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS

发明人： Guillaume CHASSAGNON ,  Marie-Pierre REVEL ,  Stéphane CHEMOUNY ,  Amandine RENÉ

IPC分类号： G06T7/00 ,  A61B6/03 ,  A61B6/00 ,  G06T7/11 ,  G06T7/162 ,  G06T7/62

摘要： The invention relates to a method for automatically processing at least one image slice of a given part of at least one lung of a patient suffering from a pathology that causes a bronchial infection by diffuse dilatation of the bronchial tubes of the lungs, the method comprising steps of segmenting (102) the at least one image slice of the given part of the lung, in order to produce a histogram characterising the pulmonary density of the given part of the lunch, by means of the voxels of the at least one image slice, each voxel being assocaited with a given pulmonary density; calculating (104) a threshold, from the histogram, corresponding to a threshold pulmonary density, based on at least one characteristic of the histogram, a first characteristic being the mode of the histogram; determining (106) from the at least one image slice of the given part of the lung, a pulmonary volume having a pulmonnar density higher or lower than the calculatedd threshold, corresponding to the sum of the voxels having a pulmonary density higher or lower than the calculated threshold; and calculating (110) an automatic score on the basis of the determined pulmonary volume, in order to monitor the evolution of the broncial infection of the patient.