公开(公告)号：US20230416196A1

公开(公告)日：2023-12-28

申请号：US18037331

申请日：2021-11-18

申请人： INSTITUT CURIE ,  INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  PARIS SCIENCES ET LETTRES

发明人： RAPHAËL RODRIGUEZ ,  ANTOINE VERSINI ,  TATIANA CAÑEQUE ,  SEBASTIAN MÜLLER ,  STÉPHANIE SOLIER ,  LEEROY BARON

IPC分类号： C07C279/26 ,  A61P35/00

CPC分类号： C07C279/265 ,  A61P35/00

摘要： The present invention relates to compounds comprising two biguanidyl radicals that can be useful as anti-inflammatory agent, and also to new compounds comprising two biguanidyl radicals and their use as a drug, in particular for treating a cancer, a metabolic disease, a secondary mitochondrial disorder due to copper overload including Indian childhood cirrhosis, Wilson's disease and Idiopathic infantile copper toxicosis or due to iron overload, an infection by a virus such as a coronavirus or an influenza virus, a neurodegenerative disease or disorder and aging.

公开(公告)号：US20210230105A1

公开(公告)日：2021-07-29

申请号：US15734569

申请日：2019-06-04

申请人： INSTITUT CURIE ,  lNSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

发明人： TATIANA CAÑEQUE ,  SEBASTIAN MULLER ,  RAPHAËL RODRIGUEZ

IPC分类号： C07C279/26 ,  A61K45/06

摘要： The present invention relates to new compounds of formula (I), and their uses.