公开(公告)号：US20230046953A1

公开(公告)日：2023-02-16

申请号：US17938865

申请日：2022-10-07

申请人： INSTITUT PASTEUR ,  INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (NRA) ,  THE UNITED STATES OF AMERICA , AS REPRESENTED BY THE SECRETARY OF AGRICULTURE

发明人： John P. BANNANTINE ,  Gilles ETIENNE ,  Sylvie BAY ,  Franck BIET

IPC分类号： C07K5/087 ,  A61K47/54 ,  A61K47/60 ,  A61K39/04 ,  C07K7/06 ,  C12Q1/689 ,  G01N33/569

摘要： The present invention is directed to an isolated synthetic tripeptide of formula H-D-Phe-N-Methyl-L-Val-L-Ala-OMe (SEQ ID NO:1), or a derivative thereof, and to the corresponding lipotripeptides, which are specific to Mycobacterium avium subsp. paratuberculosis (Map)S-type strain, as well as derivatives and conjugates thereof. The invention also concerns the use of these antigens in different methods and tests for detecting Map infection, especially by detecting humoral response and cell mediated response of infected animals. The invention is also directed to a genetic signature of Map and a mass spectrometry and NMR spectroscopy signature of Map presence or infection.

公开(公告)号：US20240270790A1

公开(公告)日：2024-08-15

申请号：US18606817

申请日：2024-03-15

申请人： INSTITUT PASTEUR ,  INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE L'ALIMENTATION ET L'ENVIRONNEMENT ,  THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF AGRICULTURE

发明人： John P. BANNANTINE ,  Gilles ETIENNE ,  Sylvie BAY ,  Franck BIET

IPC分类号： C07K5/087 ,  A61K39/04 ,  A61K47/54 ,  A61K47/60 ,  C07K7/06 ,  C12Q1/689 ,  G01N33/569

CPC分类号： C07K5/0812 ,  A61K39/04 ,  A61K47/542 ,  A61K47/60 ,  C07K7/06 ,  C12Q1/689 ,  G01N33/5695 ,  G01N2333/5428 ,  G01N2333/57 ,  G01N2469/20 ,  G01N2800/26

摘要： The present invention is directed to an isolated synthetic tripeptide of formula H-D-Phe-N-Methyl-L-Val-L-Ala-OMe (SEQ ID NO: 1), or a derivative thereof, and to the corresponding lipotripeptides, which are specific to Mycobacterium avium subsp. paratuberculosis (Map) S-type strain, as well as derivatives and conjugates thereof. The invention also concerns the use of these antigens in different methods and tests for detecting Map infection, especially by detecting humoral response and cell mediated response of infected animals. The invention is also directed to a genetic signature of Map and a mass spectrometry and NMR spectroscopy signature of Map presence or infection.

公开(公告)号：US20200024307A1

公开(公告)日：2020-01-23

申请号：US16470962

申请日：2017-12-20

申请人： INSTITUT PASTEUR ,  INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA) ,  THE UNITED STATES OF AMERICA, AS REPREESENTED BY THE SECRETARY, AGRICULTURE

发明人： John P. BANNANTINE ,  Gilles ETIENNE ,  Sylvie BAY ,  Franck BIET

IPC分类号： C07K5/087 ,  A61K47/54 ,  A61K47/60 ,  G01N33/569 ,  A61K39/04 ,  C12Q1/689 ,  C07K7/06

摘要： The present invention is directed to an isolated synthetic tripeptide of formula H-D-Phe-N-Methyl-L-Val-L-Ala-OMe (SEQ ID NO:1), or a derivative thereof, and to the corresponding lipotripeptides, which are specific to Mycobacterium avium subsp. paratuberculosis (Map) S-type strain, as well as derivatives and conjugates thereof. The invention also concerns the use of these antigens in different methods and tests for detecting Map infection, especially by detecting humoral response and cell mediated response of infected animals. The invention is also directed to a genetic signature of Map and a mass spectrometry and NMR spectroscopy signature of Map presence or infection.