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公开(公告)号：US09073813B2
公开(公告)日：2015-07-07
申请号：US13733855
申请日：2013-01-03
发明人： Mariusz Gruza , Oliwia Zegrocka-Stendel , Tomasz Giller , Grzegorz Grynkiewicz , Marta Laszcz , Kamil Jatczak
CPC分类号： C07C29/095 , C07C29/74 , C07C29/78 , C07C31/278 , C07C35/44 , C07J63/00 , C07J63/008
摘要： A process for the preparation of protoescigenin by hydrolysis of escin isolated from Aesculus hippocastanum. The process includes the following steps: a two-step hydrolysis first under acidic and then basic conditions, enrichment of the crude mixture of sapogenins with protoescigenin, an isolation of the mixture of sapogenins in a solid form, and a purification of the obtained solid and isolation of high purity protoescigenin. The invention also relates to protoescigenin monohydrate in a crystalline form and the preparation thereof. Protoescigenin is a polyhydroxy aglycone, which can be used as a synthon in the chemical modifications of naturally occurring saponins.
摘要翻译： 一种通过水解从七叶树七叶皂苷中分离的七叶皂苷制备原丝酵母素的方法。 该方法包括以下步骤：首先在酸性和碱性条件下进行两步水解，将粗皂苷元粗制混合物与原丝酵母素进行富集，分离固体形式的皂角蛋白的混合物，以及所得固体和 隔离高纯度原丝酵母。 本发明还涉及结晶形式的原生精皮质素一水合物及其制备。 原花青素是多羟基苷元，可用作天然皂苷的化学修饰中的合成子。
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公开(公告)号：US10370404B2
公开(公告)日：2019-08-06
申请号：US15553301
申请日：2016-02-26
发明人： Katarzyna Koziak , Krzysztof Bojakowski , Magdalena Kowalewska , Dorota Maciejko , Oliwia Zegrocka-Stendel , Iwona Grabowska , Grzegorz Grynkiewicz , Mariusz Marek Gruza , Kamil Jatczak , Katarzyna Filip , Piotr Cmoch , Marta Laszcz , Malgorzata Dutkiewicz
摘要： Described herein is compound including a protoescigenin derivative having pharmacological properties. Also described are a process of its preparation, and the use of such a compound as a medicament, especially for treating vascular disorders. A pharmaceutical composition comprising such compound is further described.
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公开(公告)号：US20180244714A1
公开(公告)日：2018-08-30
申请号：US15553301
申请日：2016-02-26
申请人： Katarzyna KOZIAK , Krzysztof BOJAKOWSKI , Magdalena KOWALEWSKA , Dorota MACIEJKO , Oliwia ZEGROCKA-STENDEL , Iwona GRABOWSKA , Grzegorz GRYNKIEWICZ , Mariusz Marek GRUZA , Kamil JATCZAK , Katarzyna FILIP , Piotr CMOCH , Marta LASZCZ , Instytut Farmaceutyczny
发明人： Katarzyna Koziak , Krzysztof Bojakowski , Magdalena Kowalewska , Dorota Maciejko , Oliwia Zegrocka-Stendel , Iwona Grabowska , Grzegorz Grynkiewicz , Mariusz Marek Gruza , Kamil Jatczak , Katarzyna Filip , Piotr Cmoch , Marta Laszcz
CPC分类号： C07J63/008 , A61K31/58
摘要： Described herein is compound including a protoescigenin derivative having pharmacological properties. Also described are a process of its preparation, and the use of such a compound as a medicament, especially for treating vascular disorders. A pharmaceutical composition comprising such compound is further described.
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