公开(公告)号：US20160120863A1

公开(公告)日：2016-05-05

申请号：US14893513

申请日：2014-05-22

申请人： IOMET PHARMA LTD.

发明人： Phillip Martin Cowley ,  Alan Wise ,  Thomas James Brown ,  Matthew Isherwood ,  Anjan Chakrabarti

IPC分类号： A61K31/496 ,  G01N33/50 ,  A61K45/06 ,  C07D471/04 ,  A61K31/5377

CPC分类号： A61K31/496 ,  A61K31/4985 ,  A61K31/5377 ,  A61K45/06 ,  C07D471/04 ,  C07D487/04 ,  C07D519/00 ,  G01N33/502 ,  G01N2333/705 ,  G01N2500/04 ,  G01N2500/10 ,  Y02A50/385 ,  Y02A50/414 ,  Y02A50/423

摘要： Provided is a SLC2A class I transporter inhibitor compound for use in medicine, which compound comprises the following formula: wherein A and Z may be the same or different and are each independently selected from C, N, O and S; each X may be the same or different and is independently selected from C, N, O and S; R1 and R5 may be present or absent and may be the same or different and are each selected from H and a substituted or unsubstituted organic group; Z completes a ring with each X, each ring comprising from 3 to 8 ring atoms including the X, A, and Z, each ring atom being independently selected from C, N, O and S, and each ring atom being unsubstituted or independently substituted with H or a substituted or unsubstituted organic group; and wherein the bonds between all of the atoms in the rings including the X, A, and Z may independently be single bonds or double bonds, provided that when X or a ring atom is O or S the bonds to X are single bonds.

摘要翻译： 本发明提供一种用于医药的SLC2A I类转运蛋白抑制剂化合物，该化合物包含下式：其中A和Z可以相同或不同，并且各自独立地选自C，N，O和S; 每个X可以相同或不同，并且独立地选自C，N，O和S; R 1和R 5可以存在或不存在，并且可以相同或不同，并且各自选自H和取代或未取代的有机基团; Z与每个X完成一个环，每个环包含3至8个环原子，包括X，A和Z，每个环原子独立地选自C，N，O和S，每个环原子是未取代或独立取代的 与H或取代或未取代的有机基团; 并且其中包括X，A和Z的环中所有原子之间的键可以独立地为单键或双键，条件是当X或环原子为O或S时，与X的键为单键。