公开(公告)号：US20160076031A1

公开(公告)日：2016-03-17

申请号：US14834873

申请日：2015-08-25

申请人： Isis Pharmaceuticals, Inc.

发明人： Brenda F. Baker ,  Anne B. Eldrup ,  Muthiah Manoharan ,  Balkrishen Bhat ,  Richard H. Griffey ,  Eric E. Swayze ,  Thazha P. Prakash

IPC分类号： C12N15/113

CPC分类号： C12N15/111 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/317 ,  C12N2310/319 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/342 ,  C12N2310/343 ,  C12N2310/346 ,  C12N2310/321 ,  C12N2310/3525 ,  C12N2310/3521

摘要： Oligonucleotide compositions comprising first and second oligonucleotides are provided wherein at least a portion of the first oligonucleotide is capable of hybridizing with at least a portion of the second oligonucleotide, at least a portion of the first oligonucleotide is complementary to and capable of hybridizing to a selected target nucleic acid, and at least one of the first or second oligonucleotides includes at least one nucleotide having a modified phosphorous-containing internucleoside linkage. Oligonucleotide/protein compositions are also provided comprising an oligonucleotide complementary to and capable of hybridizing to a selected target nucleic acid and at least one protein comprising at least a portion of an RNA-induced silencing complex (RISC), wherein at least one nucleotide of the oligonucleotide has a modified phosphorous-containing internucleoside linkage.

摘要翻译： 提供了包含第一和第二寡核苷酸的寡核苷酸组合物，其中至少一部分第一寡核苷酸能够与至少一部分第二寡核苷酸杂交，第一寡核苷酸的至少一部分与选定的 靶核酸，并且第一或第二寡核苷酸中的至少一个包含至少一个具有修饰的含磷核苷间键的核苷酸。 还提供了寡核苷酸/蛋白质组合物，其包含与选定的靶核酸互补并且能够与选定的靶核酸杂交的寡核苷酸和至少一种包含至少一部分RNA诱导的沉默复合物（RISC）的蛋白质，其中至少一个核苷酸 寡核苷酸具有修饰的含磷核苷键。

公开(公告)号：US20160017324A1

公开(公告)日：2016-01-21

申请号：US14746353

申请日：2015-06-22

申请人： ISIS PHARMACEUTICALS, INC.

发明人： Brenda F. Baker ,  Anne B. Eldrup ,  Muthiah Manoharan ,  Balkrishen Bhat ,  Richard H. Griffey ,  Eric E. Swayze ,  Stanley T. Crooke

IPC分类号： C12N15/113

CPC分类号： C12N15/113 ,  C07H21/02 ,  C07H21/04 ,  C12N15/111 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/341 ,  C12N2310/342 ,  C12N2310/346 ,  C12N2320/30 ,  C12N2320/51 ,  C12N2310/3521 ,  C12N2310/3533

摘要： Oligomer compositions comprising first and second oligomers are provided wherein at least a portion of the first oligomer is capable of hybridizing with at least a portion of the second oligomer, at least a portion of the first oligomer is complementary to and capable of hybridizing to a selected target nucleic acid, and at least one of the first or second oligomers includes at least one nucleotide comprising a chimeric organic composition. Oligomer/protein compositions are also provided comprising an oligomer complementary to and capable of hybridizing to a selected target nucleic acid and at least one protein comprising at least a portion of an RNA-induced silencing complex (RISC), wherein at least one nucleotide comprising a chimeric organic composition.

摘要翻译： 提供包含第一和第二寡聚体的低聚物组合物，其中至少一部分第一寡聚体能够与至少一部分第二寡聚物杂交，至少一部分第一寡聚体与选定的 靶核酸，并且所述第一或第二寡聚体中的至少一个包含至少一个包含嵌合有机组合物的核苷酸。 还提供寡聚物/蛋白质组合物，其包含与选定的靶核酸互补并且能够与选定的靶核酸杂交的寡聚体和至少一种包含至少一部分RNA诱导的沉默复合物（RISC）的蛋白质，其中至少一个核苷酸包含 嵌合有机组合物。