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公开(公告)号：US20150167005A1
公开(公告)日：2015-06-18
申请号：US14539831
申请日：2014-11-12
发明人： Susan M. Freier , Rosanne M. Crooke , Mark J. Graham , Kristina M. Lemonidis , Sanjay Bhanot , Diane Tribble , Andrew T. Watt
IPC分类号： C12N15/113
CPC分类号： C12N15/1137 , A61K45/06 , A61K48/00 , C12N2310/11 , C12N2310/321 , C12N2310/351 , C12N2320/30
摘要： Disclosed herein are antisense compounds and methods for decreasing LDL-C in an individual having elevated LDL-C. Additionally disclosed are antisense compounds and methods for treating, preventing, or ameliorating hypercholesterolemia and/or atherosclerosis. Further disclosed are antisense compounds and methods for decreasing coronary heart disease risk. Such methods include administering to an individual in need of treatment an antisense compound targeted to a PCSK9 nucleic acid. The antisense compounds administered include gapmer antisense oligonucleotides.
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公开(公告)号：US08912160B2
公开(公告)日：2014-12-16
申请号：US14152825
申请日：2014-01-10
发明人： Susan M. Freier , Rosanne M. Crooke , Mark J. Graham , Kristina M. Lemonidis , Sanjay Bhanot , Andrew T. Watt , Diane Tribble
CPC分类号： C12N15/1137 , A61K45/06 , A61K48/00 , C12N2310/11 , C12N2310/321 , C12N2310/351 , C12N2320/30
摘要： Disclosed herein are antisense compounds and methods for decreasing LDL-C in an individual having elevated LDL-C. Additionally disclosed are antisense compounds and methods for treating, preventing, or ameliorating hypercholesterolemia and/or atherosclerosis. Further disclosed are antisense compounds and methods for decreasing coronary heart disease risk. Such methods include administering to an individual in need of treatment an antisense compound targeted to a PCSK9 nucleic acid. The antisense compounds administered include gapmer antisense oligonucleotides.
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公开(公告)号：US20140194492A1
公开(公告)日：2014-07-10
申请号：US14152825
申请日：2014-01-10
发明人： Susan M. Freier , Rosanne M. Crooke , Mark J. Graham , Kristina M. Lemonidis , Sanjay Bhanot , Diane Tribble , Andrew T. Watt
IPC分类号： C12N15/113
CPC分类号： C12N15/1137 , A61K45/06 , A61K48/00 , C12N2310/11 , C12N2310/321 , C12N2310/351 , C12N2320/30
摘要： Disclosed herein are antisense compounds and methods for decreasing LDL-C in an individual having elevated LDL-C. Additionally disclosed are antisense compounds and methods for treating, preventing, or ameliorating hypercholesterolemia and/or atherosclerosis. Further disclosed are antisense compounds and methods for decreasing coronary heart disease risk. Such methods include administering to an individual in need of treatment an antisense compound targeted to a PCSK9 nucleic acid. The antisense compounds administered include gapmer antisense oligonucleotides.
摘要翻译： 本文公开了用于降低具有升高的LDL-C的个体中的LDL-C的反义化合物和方法。 另外公开了用于治疗，预防或改善高胆固醇血症和/或动脉粥样硬化的反义化合物和方法。 进一步公开的是用于降低冠心病风险的反义化合物和方法。 这样的方法包括向需要治疗的个体施用靶向PCSK9核酸的反义化合物。 施用的反义化合物包括gapmer反义寡核苷酸。
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公开(公告)号：US20130317085A1
公开(公告)日：2013-11-28
申请号：US13961646
申请日：2013-08-07
IPC分类号： C12N15/113
CPC分类号： C12N15/113 , A61K38/00 , C12N2310/11 , C12N2310/314 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/351 , C12N2320/30 , C12N2330/31 , C12N2310/3521
摘要： Compounds, compositions and methods are provided for modulating the expression of apolipoprotein C-III. The compositions comprise oligonucleotides, targeted to nucleic acid encoding apolipoprotein C-III. Methods of using these compounds for modulation of apolipoprotein C-III expression and for diagnosis and treatment of disease associated with expression of apolipoprotein C-III are provided
摘要翻译： 提供化合物，组合物和方法用于调节载脂蛋白C-III的表达。 组合物包含靶向编码载脂蛋白C-III的核酸的寡核苷酸。 提供了使用这些化合物调节载脂蛋白C-III表达和诊断和治疗与载脂蛋白C-III表达相关的疾病的方法
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公开(公告)号：US09650636B2
公开(公告)日：2017-05-16
申请号：US14539831
申请日：2014-11-12
发明人： Susan M. Freier , Rosanne M. Crooke , Mark J. Graham , Kristina M. Lemonidis , Sanjay Bhanot , Diane Tribble , Andrew T. Watt
CPC分类号： C12N15/1137 , A61K45/06 , A61K48/00 , C12N2310/11 , C12N2310/321 , C12N2310/351 , C12N2320/30
摘要： Disclosed herein are antisense compounds and methods for decreasing LDL-C in an individual having elevated LDL-C. Additionally disclosed are antisense compounds and methods for treating, preventing, or ameliorating hypercholesterolemia and/or atherosclerosis. Further disclosed are antisense compounds and methods for decreasing coronary heart disease risk. Such methods include administering to an individual in need of treatment an antisense compound targeted to a PCSK9 nucleic acid. The antisense compounds administered include gapmer antisense oligonucleotides.
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