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公开(公告)号：US08865884B2
公开(公告)日：2014-10-21
申请号：US13905306
申请日：2013-05-30
发明人： Kenneth W. Dobie , Erich Koller , Ravi Jain
CPC分类号： C12N15/113 , A01K2267/0331 , A61K31/711 , A61K31/713 , A61K48/00 , C12N15/1137 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525 , C12N2310/3521
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of kinesin-like 1. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding kinesin-like 1. Methods of using these compounds for modulation of kinesin-like 1 expression and for treatment of diseases associated with expression of kinesin-like 1 are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节驱动蛋白样1的表达。组合物包含靶向编码驱动蛋白样物质的核酸的反义化合物，特别是反义寡核苷酸1.使用这些化合物调节驱动蛋白样1 提供表达和用于治疗与驱动蛋白样1的表达相关的疾病。
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公开(公告)号：US20160060626A1
公开(公告)日：2016-03-03
申请号：US14821982
申请日：2015-08-10
IPC分类号： C12N15/113 , C12Q1/68
CPC分类号： C12N15/113 , C12N15/1136 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3231 , C12N2310/3341 , C12N2310/341 , C12N2320/30 , C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , G01N33/5023 , C12N2310/3521
摘要： Provided herein are methods, compounds, and compositions for reducing expression of an ANGPTL3 mRNA and protein in an animal. Also provided herein are methods, compounds, and compositions for reducing plasma lipids, plasma glucose and atherosclerotic plaques in an animal. Such methods, compounds, and compositions are useful to treat, prevent, delay, or ameliorate any one or more of cardiovascular disease or metabolic disease, or a symptom thereof.
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3.发明申请公开(公告)号：US20160060625A1
公开(公告)日：2016-03-03
申请号：US14821641
申请日：2015-08-07
发明人： Adam Mullick , Rosanne M. Crooke , Mark J. Graham , Kenneth W. Dobie , Thomas A. Bell, III , Richard Lee
IPC分类号： C12N15/113
CPC分类号： C12N15/113 , A61K31/7088 , A61K31/713 , A61K45/06 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/341 , C12N2310/346 , C12N2310/351 , A61K2300/00
摘要： Provided herein are methods, compounds, and compositions for reducing expression of ApoCIII mRNA and protein in an animal. Also provided herein are methods, compounds, and compositions for increasing HDL levels and/or improving the ratio of TG to HDL and reducing plasma lipids and plasma glucose in an animal. Such methods, compounds, and compositions are useful to treat, prevent, delay, or ameliorate any one or more of cardiovascular disease or metabolic disorder, or a symptom thereof.
摘要翻译： 本文提供了用于在动物中降低ApoCIII mRNA和蛋白质表达的方法，化合物和组合物。 本文还提供了用于增加HDL水平和/或改善动物体内TG与HDL的比例以及降低血浆脂质和血浆葡萄糖的方法，化合物和组合物。 这些方法，化合物和组合物可用于治疗，预防，延迟或改善心血管疾病或代谢紊乱或其症状中的任何一种或多种。
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公开(公告)号：US20130331435A1
公开(公告)日：2013-12-12
申请号：US13905306
申请日：2013-05-30
发明人： Kenneth W. Dobie , Erich Koller , Ravi Jain
IPC分类号： C12N15/113
CPC分类号： C12N15/113 , A01K2267/0331 , A61K31/711 , A61K31/713 , A61K48/00 , C12N15/1137 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525 , C12N2310/3521
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of kinesin-like 1. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding kinesin-like 1. Methods of using these compounds for modulation of kinesin-like 1 expression and for treatment of diseases associated with expression of kinesin-like 1 are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节驱动蛋白样1的表达。组合物包含靶向编码驱动蛋白样物质的核酸的反义化合物，特别是反义寡核苷酸1.使用这些化合物调节驱动蛋白样1 提供表达和用于治疗与驱动蛋白样1的表达相关的疾病。
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公开(公告)号：US20130178513A1
公开(公告)日：2013-07-11
申请号：US13780955
申请日：2013-02-28
IPC分类号： C07H21/00
CPC分类号： C07H21/00 , A61K38/00 , C12N15/113 , C12N2310/13 , C12N2310/315 , C12N2310/3181 , C12N2310/32 , C12N2310/321 , C12N2310/322 , C12N2310/3231 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/53 , C12N2310/3525 , C12N2310/3521 , C12N2310/3533
摘要： Oligomeric compounds, compositions and methods are provided for modulating the expression of eIF4E. The antisense compounds may be single- or double-stranded and are targeted to nucleic acid encoding eIF4E. Methods of using these compounds for modulation of eIF4E expression and for diagnosis and treatment of diseases and conditions associated with expression of eIF4E are provided.
摘要翻译： 提供低分子化合物，组合物和方法用于调节eIF4E的表达。 反义化合物可以是单链或双链的，并且靶向编码eIF4E的核酸。 提供了使用这些化合物调节eIF4E表达和用于诊断和治疗与eIF4E表达相关的疾病和病症的方法。
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公开(公告)号：US09139831B2
公开(公告)日：2015-09-22
申请号：US14149715
申请日：2014-01-07
IPC分类号： C12N15/113 , G01N33/50
CPC分类号： C12N15/113 , C12N15/1136 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3231 , C12N2310/3341 , C12N2310/341 , C12N2320/30 , C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , G01N33/5023 , C12N2310/3521
摘要： Provided herein are methods, compounds, and compositions for reducing expression of an ANGPTL3 mRNA and protein in an animal. Also provided herein are methods, compounds, and compositions for reducing plasma lipids, plasma glucose and atherosclerotic plaques in an animal. Such methods, compounds, and compositions are useful to treat, prevent, delay, or ameliorate any one or more of cardiovascular disease or metabolic disease, or a symptom thereof.
摘要翻译： 本文提供了用于减少动物中ANGPTL3 mRNA和蛋白质表达的方法，化合物和组合物。 本文还提供了用于降低动物体内血浆脂质，血浆葡萄糖和动脉粥样硬化斑块的方法，化合物和组合物。 这些方法，化合物和组合物可用于治疗，预防，延迟或改善心血管疾病或代谢疾病或其症状中的任何一种或多种。
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公开(公告)号：US20150167008A1
公开(公告)日：2015-06-18
申请号：US14630581
申请日：2015-02-24
发明人： C. Frank Bennett , Kenneth W. Dobie
IPC分类号： C12N15/113
CPC分类号： C12N15/1137 , A61K38/00 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525 , C12Y115/01001 , Y02P20/582
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of superoxide dismutase 1, soluble. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding superoxide dismutase 1, soluble. Methods of using these compounds for modulation of superoxide dismutase 1, soluble expression and for treatment of diseases associated with expression of superoxide dismutase 1, soluble are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节超氧化物歧化酶1的表达，可溶性。 组合物包含靶向编码超氧化物歧化酶1的核酸的可反应化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节超氧化物歧化酶1，可溶性表达和治疗与超氧化物歧化酶1表达相关的疾病的方法。
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公开(公告)号：US20130317085A1
公开(公告)日：2013-11-28
申请号：US13961646
申请日：2013-08-07
IPC分类号： C12N15/113
CPC分类号： C12N15/113 , A61K38/00 , C12N2310/11 , C12N2310/314 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/351 , C12N2320/30 , C12N2330/31 , C12N2310/3521
摘要： Compounds, compositions and methods are provided for modulating the expression of apolipoprotein C-III. The compositions comprise oligonucleotides, targeted to nucleic acid encoding apolipoprotein C-III. Methods of using these compounds for modulation of apolipoprotein C-III expression and for diagnosis and treatment of disease associated with expression of apolipoprotein C-III are provided
摘要翻译： 提供化合物，组合物和方法用于调节载脂蛋白C-III的表达。 组合物包含靶向编码载脂蛋白C-III的核酸的寡核苷酸。 提供了使用这些化合物调节载脂蛋白C-III表达和诊断和治疗与载脂蛋白C-III表达相关的疾病的方法
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公开(公告)号：US20140309282A1
公开(公告)日：2014-10-16
申请号：US14315186
申请日：2014-06-25
IPC分类号： C12N15/113
CPC分类号： C12N15/113 , C12N15/111 , C12N2310/11 , C12N2320/33
摘要： Disclosed herein are compounds, compositions and methods for modulating the expression of LMNA in a cell, tissue or animal. Also provided are methods of target validation. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders. Further provided are methods of identifying cis splicing regulatory elements of a selected mRNA using the disclosed compounds.
摘要翻译： 本文公开了用于调节细胞，组织或动物中LMNA表达的化合物，组合物和方法。 还提供了目标验证的方法。 还提供了所公开的化合物和组合物在制备用于治疗疾病和病症的药物中的用途。 还提供了使用所公开的化合物鉴定所选mRNA的顺式剪接调节元件的方法。
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公开(公告)号：US20140193825A1
公开(公告)日：2014-07-10
申请号：US14149715
申请日：2014-01-07
IPC分类号： C12N15/113 , G01N33/50
CPC分类号： C12N15/113 , C12N15/1136 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3231 , C12N2310/3341 , C12N2310/341 , C12N2320/30 , C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , G01N33/5023 , C12N2310/3521
摘要： Provided herein are methods, compounds, and compositions for reducing expression of an ANGPTL3 mRNA and protein in an animal. Also provided herein are methods, compounds, and compositions for reducing plasma lipids, plasma glucose and atherosclerotic plaques in an animal. Such methods, compounds, and compositions are useful to treat, prevent, delay, or ameliorate any one or more of cardiovascular disease or metabolic disease, or a symptom thereof.
摘要翻译： 本文提供了用于减少动物中ANGPTL3 mRNA和蛋白质表达的方法，化合物和组合物。 本文还提供了用于降低动物体内血浆脂质，血浆葡萄糖和动脉粥样硬化斑块的方法，化合物和组合物。 这些方法，化合物和组合物可用于治疗，预防，延迟或改善心血管疾病或代谢疾病或其症状中的任何一种或多种。
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