公开(公告)号：US20220315911A1

公开(公告)日：2022-10-06

申请号：US17837269

申请日：2022-06-10

申请人： ISOBIONICS B.V.

发明人： Martinus Julius BEEKWILDER ,  Adèle Margaretha Maria Liduina Van Houwelingen ,  Hendrik Jan Bosch ,  Georg Friedrich Lentzen ,  Elena Melillo ,  Hendrik Wouter Wisselink

IPC分类号： C12N9/88 ,  C07K16/40 ,  C12P5/00 ,  C12P7/02 ,  C12N15/80 ,  C12N15/82

摘要： The invention is directed to a santalene synthase, to a nucleic acid encoding said santalene synthase, to an expression vector comprising said nucleic acid, to a host cell comprising said expression vector, to a method of preparing santalene, to a method of preparing santalol and to a method of preparing a santalene synthase. The invention is further directed to an antibody specific for the santalane synthase.

公开(公告)号：US11584941B2

公开(公告)日：2023-02-21

申请号：US16643740

申请日：2018-09-01

申请人： ISOBIONICS B.V.

发明人： Martinus Julius Beekwilder ,  Adèle Margaretha Maria Liduina Van Houwelingen ,  Hendrik Jan Bosch ,  Georg Friedrich Lentzen ,  Elena Melillo

IPC分类号： C12N15/63 ,  C12P7/02 ,  C12N9/88 ,  C12N15/80

摘要： The invention is directed to a patchoulol synthase, to a nucleic acid encoding said patchoulol synthase, to an expression vector comprising said nucleic acid, to a host cell comprising said expression vector, to a method of preparing patchoulol and elemol, and preferably also pogostol, and to a method of preparing a patchoulol synthase.

公开(公告)号：US11072805B2

公开(公告)日：2021-07-27

申请号：US16257709

申请日：2019-01-25

申请人： ISOBIONICS B.V.

发明人： Antonius Cornelis Johannes Matheus Janssen ,  Joannes Gerardus Theodorus Kierkels ,  Georg Friedrich Lentzen

IPC分类号： C12P5/00

摘要： The invention relates to a two phase fermentation process for producing an organic compound, in particular an isoprenoid and to a bioreactor comprising a two phase fermentation system for producing an organic compound.

公开(公告)号：US11041175B2

公开(公告)日：2021-06-22

申请号：US16257709

申请日：2019-01-25

申请人： ISOBIONICS B.V.

发明人： Antonius Cornelis Johannes Matheus Janssen ,  Joannes Gerardus Theodorus Kierkels ,  Georg Friedrich Lentzen

IPC分类号： C12P5/00

摘要： The invention relates to a two phase fermentation process for producing an organic compound, in particular an isoprenoid and to a bioreactor comprising a two phase fermentation system for producing an organic compound.