公开(公告)号：US20180371000A1

公开(公告)日：2018-12-27

申请号：US15774754

申请日：2016-11-10

Applicant: ISP INVESTMENTS LLC

Inventor： Elodie OGER ,  Valerie LEQUOY ,  Frederique PORTOLAN

IPC: C07H1/08 ,  C07H21/02 ,  A61Q19/08 ,  A61Q19/00 ,  A61K8/44 ,  A61K8/60 ,  A61K8/9789 ,  A61K8/9794

Abstract: The invention relates to a method for obtaining an aqueous extract enriched with small RNA having a maximum length of 150 nucleotides, from plant material. The invention is characterized in that it comprises the following steps according to which: a) the plant material is put in contact with water; b) tetrasodium ethylenediaminetetraacetic acid (EDTA) is added to the mixture obtained in a) at a pH between 10.5 and 11; c) then, the pH of the mixture obtained in b) is adjusted to a value between 6 and 8; d) the mixture obtained in c) is purified in such a manner as to eliminate the plant material and to recover an aqueous raw extract; and e) the pH is checked and readjusted if necessary to a value between 6 and 8. The invention also relates to an aqueous extract of plant material, enriched with small RNAs having a maximum length of 150 nucleotides, which can be obtained by such a method, as well as to the compositions comprising such an extract and to their cosmetic uses for combating the signs of skin aging and for improving the hydration of the skin.