公开(公告)号：US20230348368A1

公开(公告)日：2023-11-02

申请号：US18338435

申请日：2023-06-21

Applicant: ITALFARMACO SPA

Inventor： Stefano TURCHETTA ,  Maurio ZENONI ,  Elio ULLUCCI ,  Stefania COCCIOLO ,  Giorgio Berardi ,  Nakia MAULUCCI

IPC: C07C271/28 ,  C07C269/06 ,  B01J20/286 ,  C07C269/08

CPC classification number: C07C271/28 ,  C07C269/06 ,  B01J20/286 ,  C07C269/08 ,  G01N2030/027

Abstract: A process for obtaining {{6-[(diethylamino)methyl]naphthalen-2-yl}methyl [4-(hydroxycarbamoyl)phenyl]carbamate and/or pharmaceutically acceptable salts thereof having high purity is described. This process allows to obtain a product having an amount of any single unknown impurity equal to or less than 0.10%, as well as a product having a purity greater than 99.5%, preferably equal to or greater than 99.6%.
An HPLC method for determining the purity of the product and possible impurities thereof is also described.