专利检索 ap:("ITEOS BELGIUM SA") AND inv:"Stefano Crosginani" 第 1 页

1.

发明公开
MACROCYCLIC DIAMINE DERIVATIVES AS ENT INHIBITORS FOR THE TREATMENT OF CANCERS, AND COMBINATION THEREOF WITH ADENOSINE RECEPTOR ANTAGONISTS 审中-公开

公开(公告)号：US20230203058A1

公开(公告)日：2023-06-29

申请号：US17917462

申请日：2021-04-07

申请人： ITEOS BELGIUM SA

发明人： Michael Deligny , Stefano Crosginani , Erica Joke Katelijne Houthuys

IPC分类号： C07D498/08 , A61P35/00 , C07D487/08 , C07D487/18 , C07D273/08 , A61K45/06 , A61K31/551 , A61K31/395

CPC分类号： C07D498/08 , A61K31/395 , A61K31/551 , A61K45/06 , A61P35/00 , C07D273/08 , C07D487/08 , C07D487/18

摘要： The present invention relates to macrocyclic diamine derivatives of formula II, including pharmaceutically acceptable salts and solvates thereof. Compounds of the invention are inhibitors of ENT family transporter, especially of ENT1, and are useful as therapeutic compounds for the treatment of cancers. The invention also relates to the combined use of the macrocyclic diamine derivatives with an adenosine receptor antagonist, for the treatment of cancers.

2.

发明公开
PYRIMIDO[5,4-d]PYRIMIDINE DERIVATIVES AS ENT INHIBITORS FOR THE TREATMENT OF CANCERS, AND COMBINATION THEREOF WITH ADENOSINE RECEPTOR ANTAGONISTS 审中-公开

公开(公告)号：US20230146675A1

公开(公告)日：2023-05-11

申请号：US17895667

申请日：2022-08-25

申请人： ITEOS BELGIUM SA

发明人： Michael Deligny , Stefano Crosginani , Erica Joke Katelijne Houthuys

IPC分类号： C07D487/04 , C07D513/14

CPC分类号： C07D487/04 , C07D513/14

摘要： The present invention relates to pyrimido[5,4-d]pyrimidine derivatives of formula I, including pharmaceutically acceptable salts and solvates thereof.

Compounds of the invention are inhibitors of ENT family transporter, especially of ENT1, and are useful as therapeutic compounds for the treatment of cancers. The invention also relates to the combined use of the pyrimido[5,4-d]pyrimidine derivatives with an adenosine receptor antagonist, for the treatment of cancers.