公开(公告)号：US20230285383A1

公开(公告)日：2023-09-14

申请号：US18130943

申请日：2023-04-05

Applicant: Ichilov Tech Ltd.

Inventor： Eli SPRECHER ,  Ofer SARIG

IPC: A61K31/4745 ,  A61P17/06 ,  A61P29/00 ,  A61K9/00

CPC classification number: A61K31/4745 ,  A61P17/06 ,  A61P29/00 ,  A61K9/0014

Abstract: Compounds represented by Formula A as defined in the specification for use in treating skin diseases such as, for example, psoriasis, or atopic dermatitis, in a subject in need thereof are disclosed. Compositions containing these compounds, formulated for topical application, are also disclosed.

公开(公告)号：US20220226348A1

公开(公告)日：2022-07-21

申请号：US17610276

申请日：2020-05-13

Applicant: ICHILOV TECH LTD ,  RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Eli SPRECHER ,  Ofer SARIG ,  Janan MOHAMAD ,  Alon PELED

IPC: A61K31/56 ,  A61K9/00 ,  A61K47/06 ,  A61P17/00

Abstract: The present invention provides a method and a pharmaceutical composition for treatment of skin diseases associated with accelerated comeodesmosomes degradation and/or weaker cell-cell adhesion, such as a peeling skin syndrome, Netherton syndrome, and atopic dermatitis.