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公开(公告)号：US20230348442A1
公开(公告)日：2023-11-02
申请号：US18251273
申请日：2021-11-01
发明人： Martin BOLLI , John GATFIELD , Corinna GRISOSTOMI , Lubos REMEN , Christoph SAGER , Cornelia ZUMBRUNN
IPC分类号： C07D405/04
CPC分类号： C07D405/04
摘要： The present invention relates to compounds of Formula (I)
wherein Ar1, Ar2, L, n, and R1 are as described in the description, their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of Formula (I), and especially to their use as Galectin-3 inhibitors.-
公开(公告)号：US20220306674A1
公开(公告)日：2022-09-29
申请号：US17633941
申请日：2020-08-06
发明人： Martin BOLLI , Daniel BUR , John GATFIELD , Corinna GRISOSTOMI , Lubos REMEN , Cornelia ZUMBRUNN
IPC分类号： C07H19/056
摘要： The present invention relates to compounds of Formula (I) wherein Ar1, R1, R2a, R2b, and R3 are as described in the description, their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of Formula (I), and especially to their use as Galectin-3 inhibitors.
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公开(公告)号：US20220281855A1
公开(公告)日：2022-09-08
申请号：US17638799
申请日：2020-08-28
发明人： Martin BOLLI , John GATFIELD , Corinna GRISOSTOMI , Lubos REMEN , Christoph SAGER , Cornelia ZUMBRUNN
IPC分类号： C07D405/14 , C07D413/14 , C07D417/14
摘要： The present invention relates to compounds of Formula (I) wherein Ar1, R1 and R2 are as described in the description, and A is 4,5-dihydroisoxazole-3,5-diyl, imidazolidin-4-one-1,3-diyl, oxazol-2-one-3,5-diyl and oxazolidine-2-one-3,5-diyl, 1,2,3-triazole-1,4-diyl, isoxazole-3,5-diyl, imidazole-1, 4-diyl, and isothiazole-3,5-diyl; and their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of Formula (I), and especially to their use as Galectin-3 inhibitors.
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公开(公告)号：US20240124427A1
公开(公告)日：2024-04-18
申请号：US18264751
申请日：2022-02-08
发明人： Martin BOLLI , John GATFIELD , Corinna GRISOSTOMI , Lubos REMEN , Christoph SAGER , Cornelia ZUMBRUNN
IPC分类号： C07D405/14
CPC分类号： C07D405/14
摘要： The present invention relates to compounds of Formula (I)
wherein X, Ar1, Ar2, L, n, m, and R1 are as described in the description, their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of Formula (I), and especially to their use as Galectin-3 inhibitors.-
公开(公告)号：US20230295182A1
公开(公告)日：2023-09-21
申请号：US18248007
申请日：2021-10-05
发明人： Martin BOLLLI , John GATFIELD , Corinna GRISOSTOMI , Lubos REMEN , Christoph SAGER , Cornelia ZUMBRUNN
IPC分类号： C07D498/10 , C07D413/14
CPC分类号： C07D498/10 , C07D413/14
摘要： The present invention relates to compounds of Formula (I)
wherein Ar1, A, B, and R1 are as described in the description, their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of Formula (I), and especially to their use as Galectin-3 inhibitors.-
公开(公告)号：US20240109930A1
公开(公告)日：2024-04-04
申请号：US18548833
申请日：2022-03-02
发明人： Martin BOLLI , John GATFIELD , Corinna GRISOSTOMI , Lubos REMEN , Christoph SAGER , Cornelia ZUMBRUNN
摘要： The present invention relates to Galectin-3 inhibitors of Formula (I) and pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising such compounds, and their medical uses.
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公开(公告)号：US20220324847A1
公开(公告)日：2022-10-13
申请号：US17634512
申请日：2020-08-14
发明人： Martin BOLLI , John GATFIELD , Corinna GRISOSTOMI , Lubos REMEN , Christoph SAGER , Cornelia ZUMBRUNN
IPC分类号： C07D405/04 , C07D405/14 , C07D417/14 , C07D413/14 , C07D409/14
摘要： The present invention relates to compounds of Formula (I) wherein Ar1, Ar2, L, n, and R1 are as described in the description, their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of Formula (I), and especially to their use as Galectin-3 inhibitors.
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公开(公告)号：US20220315619A1
公开(公告)日：2022-10-06
申请号：US17633895
申请日：2020-08-07
发明人： Martin BOLLI , Daniel BUR , John GATFIELD , Corinna GRISOSTOMI , Lubos REMEN , Cornelia ZUMBRUNN
IPC分类号： C07H19/056
摘要： The present invention relates to compounds of Formula (I) wherein Ar1, Ar2, R1a, R1b, and R2 are as described in the description, their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of Formula (I), and especially to their use as Galectin-3 inhibitors.
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