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公开(公告)号：US20090005364A1
公开(公告)日：2009-01-01
申请号：US11794051
申请日：2005-12-22
申请人： Ilaria Peretto , Francesca Scarpitta , Elena La Porta , Luca Raveglia , Giuseppe Arnaldo Maria Giardina , Bruno Pietro Imbimbo , Andrea Rizzi , Gino Villetti
发明人： Ilaria Peretto , Francesca Scarpitta , Elena La Porta , Luca Raveglia , Giuseppe Arnaldo Maria Giardina , Bruno Pietro Imbimbo , Andrea Rizzi , Gino Villetti
IPC分类号： A61K31/55 , C07D401/04 , C07D403/04 , C07D401/14 , A61P1/00 , A61P11/00 , A61K31/4439 , A61K31/454
CPC分类号： C07D401/14 , C07D401/04
摘要： The present invention relates to compounds of formula (I) wherein R1, R2, x, X, Y and B are as defined in the description for the treatment of muscarinic acetylcholine receptor mediated diseases, in particular M3 muscarinic receptor mediated diseases.
摘要翻译： 本发明涉及式（I）化合物，其中R 1，R 2，X，X，Y和B如描述中所述，用于治疗毒蕈碱性乙酰胆碱受体介导的疾病，特别是M3毒蕈碱受体介导的疾病。
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2.发明授权1-phenylalkanecarboxylic acid derivatives for the treatment of neurodegenerative diseases 有权1-苯基链烷羧酸衍生物，用于治疗神经变性疾病公开(公告)号：US08314268B2
公开(公告)日：2012-11-20
申请号：US13204989
申请日：2011-08-08
申请人： Luca Raveglia , Ilaria Peretto , Stefano Radaelli , Bruno Pietro Imbimbo , Andrea Rizzi , Gino Villetti
发明人： Luca Raveglia , Ilaria Peretto , Stefano Radaelli , Bruno Pietro Imbimbo , Andrea Rizzi , Gino Villetti
IPC分类号： C07C61/04
CPC分类号： C07C69/65 , C07C57/60 , C07C57/62 , C07C61/40 , C07C233/11 , C07C2601/02
摘要： 1-Phenylalkanecarboxylic acid derivatives, the processes for the preparation thereof and the use thereof in the treatment and/or prevention of neurodegenerative diseases such as Alzheimer's disease.
摘要翻译： 1-苯基链烷酸羧酸衍生物，其制备方法及其在治疗和/或预防神经变性疾病如阿尔茨海默氏病中的应用。
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3.发明授权1-phenylalkanecarboxylic acid derivatives for the treatment of neurodegenerative diseases 有权1-苯基链烷羧酸衍生物，用于治疗神经变性疾病公开(公告)号：US07662995B2
公开(公告)日：2010-02-16
申请号：US10546190
申请日：2004-02-19
申请人： Luca Raveglia , Ilaria Peretto , Stefano Radaelli , Bruno Pietro Imbimbo , Andrea Rizzi , Gino Villetti
发明人： Luca Raveglia , Ilaria Peretto , Stefano Radaelli , Bruno Pietro Imbimbo , Andrea Rizzi , Gino Villetti
CPC分类号： C07C69/65 , C07C57/60 , C07C57/62 , C07C61/40 , C07C233/11 , C07C2601/02
摘要： 1-Phenylalkanecarboxylic acid derivatives, the processes for the preparation thereof and the use thereof in the treatment and/or prevention of neurodegenerative diseases such as Alzheimer's disease.
摘要翻译： 1-苯基链烷酸羧酸衍生物，其制备方法及其在治疗和/或预防神经变性疾病如阿尔茨海默氏病中的应用。
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4.发明申请1-PHENYLALKANECARBOXYLIC ACID DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES 有权用于治疗神经损伤性疾病的1-苯甲酰氧基酸衍生物公开(公告)号：US20100099768A1
公开(公告)日：2010-04-22
申请号：US12647069
申请日：2009-12-24
申请人： Luca RAVEGLIA , Ilaria Peretto , Stefano Radaelli , Bruno Pietro Imbimbo , Andrea Rizzi , Gino Villetti
发明人： Luca RAVEGLIA , Ilaria Peretto , Stefano Radaelli , Bruno Pietro Imbimbo , Andrea Rizzi , Gino Villetti
IPC分类号： A61K31/192 , A61P25/28 , C07C63/33
CPC分类号： C07C69/65 , C07C57/60 , C07C57/62 , C07C61/40 , C07C233/11 , C07C2601/02
摘要： 1-Phenylalkanecarboxylic acid derivatives, the processes for the preparation thereof and the use thereof in the treatment and/or prevention of neurodegenerative diseases such as Alzheimer's disease.
摘要翻译： 1-苯基链烷酸羧酸衍生物，其制备方法及其在治疗和/或预防神经变性疾病如阿尔茨海默氏病中的应用。
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5.发明授权Derivatives of 1-phenylalkanecarboxylic acids for the treatment of neurodegenerative diseases 有权1-苯基链烷羧酸的衍生物用于治疗神经变性疾病公开(公告)号：US07531692B2
公开(公告)日：2009-05-12
申请号：US11572974
申请日：2005-07-26
申请人： Luca Raveglia , Ilaria Peretto , Stefano Radaelli , Bruno Pietro Imbimbo , Andrea Rizzi , Gino Villetti
发明人： Luca Raveglia , Ilaria Peretto , Stefano Radaelli , Bruno Pietro Imbimbo , Andrea Rizzi , Gino Villetti
IPC分类号： C07C233/05 , A61K31/16
CPC分类号： C07C237/22
摘要： The present invention concerns novel derivatives of 1-phenylalkanecarboxylic acids, pharmaceutical compositions thereof, a process for their preparation and their use for the treatment and/or prevention of neurodegenerative diseases such as Alzheimer's disease.
摘要翻译： 本发明涉及1-苯基链烷羧酸的新衍生物，其药物组合物，其制备方法及其用于治疗和/或预防神经变性疾病如阿尔茨海默病的用途。
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6.发明申请1-PHENYLALKANECARBOXYLIC ACID DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES 有权用于治疗神经损伤性疾病的1-苯甲酰氧基酸衍生物公开(公告)号：US20110288175A1
公开(公告)日：2011-11-24
申请号：US13204989
申请日：2011-08-08
申请人： Luca RAVEGLIA , Ilaria Peretto , Stefano Radaelli , Bruno Pietro Imbimbo , Andrea Rizzi , Gino Villetti
发明人： Luca RAVEGLIA , Ilaria Peretto , Stefano Radaelli , Bruno Pietro Imbimbo , Andrea Rizzi , Gino Villetti
IPC分类号： A61K31/192 , C07C62/12 , A61P25/28 , C07C57/58
CPC分类号： C07C69/65 , C07C57/60 , C07C57/62 , C07C61/40 , C07C233/11 , C07C2601/02
摘要： 1-Phenylalkanecarboxylic acid derivatives, the processes for the preparation thereof and the use thereof in the treatment and/or prevention of neurodegenerative diseases such as Alzheimer's disease.
摘要翻译： 1-苯基链烷酸羧酸衍生物，其制备方法及其在治疗和/或预防神经变性疾病如阿尔茨海默氏病中的应用。
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7.发明申请Derivatives of 1-Phenylalkanecarboxylic Acids for the Treatment of Neurodegenerative Diseases 有权用于治疗神经退行性疾病的1-苯基烷羧酸的衍生物公开(公告)号：US20080096968A1
公开(公告)日：2008-04-24
申请号：US11572974
申请日：2005-07-26
申请人： Luca Raveglia , Ilaria Peretto , Stefano Radaelli , Bruno Pietro Imbimbo , Andrea Rizzi , Gino Villetti
发明人： Luca Raveglia , Ilaria Peretto , Stefano Radaelli , Bruno Pietro Imbimbo , Andrea Rizzi , Gino Villetti
IPC分类号： A61K31/192 , A61P25/28 , C07C59/13
CPC分类号： C07C237/22
摘要： The present invention concerns novel derivatives of 1-phenylalkanecarboxylic acids, pharmaceutical compositions thereof, a process for their preparation and their use for the treatment and/or prevention of neurodegenerative diseases such as Alzheimer' s disease.
摘要翻译： 本发明涉及1-苯基链烷羧酸的新衍生物，其药物组合物，其制备方法及其用于治疗和/或预防神经变性疾病如阿尔茨海默氏病的用途。
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8.发明授权1-phenylalkanecarboxylic acid derivatives for the treatment of neurodegenerative diseases 有权1-苯基链烷羧酸衍生物，用于治疗神经变性疾病公开(公告)号：US08022250B2
公开(公告)日：2011-09-20
申请号：US12647069
申请日：2009-12-24
申请人： Luca Raveglia , Ilaria Peretto , Stefano Radaelli , Bruno Pietro Imbimbo , Andrea Rizzi , Gino Villetti
发明人： Luca Raveglia , Ilaria Peretto , Stefano Radaelli , Bruno Pietro Imbimbo , Andrea Rizzi , Gino Villetti
IPC分类号： C07C307/02 , A61K31/18
CPC分类号： C07C69/65 , C07C57/60 , C07C57/62 , C07C61/40 , C07C233/11 , C07C2601/02
摘要： 1-Phenylalkanecarboxylic acid derivatives, the processes for the preparation thereof and the use thereof in the treatment and/or prevention of neurodegenerative diseases such as Alzheimer's disease.
摘要翻译： 1-苯基链烷酸羧酸衍生物，其制备方法及其在治疗和/或预防神经变性疾病如阿尔茨海默氏病中的应用。
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9.发明申请1-Phenylalkanecarboxylic acid derivatives for the treatment of neurodegenerative diseases 有权1-苯基链烷羧酸衍生物用于治疗神经变性疾病公开(公告)号：US20070060752A1
公开(公告)日：2007-03-15
申请号：US10546190
申请日：2004-02-19
申请人： Luca Raveglia , Ilaria Peretto , Stefano Radaelli , Bruno Imbimbo , Andrea Rizzi , Gino Villetti
发明人： Luca Raveglia , Ilaria Peretto , Stefano Radaelli , Bruno Imbimbo , Andrea Rizzi , Gino Villetti
IPC分类号： C07D417/02 , C07D413/02 , C07D403/02
CPC分类号： C07C69/65 , C07C57/60 , C07C57/62 , C07C61/40 , C07C233/11 , C07C2601/02
摘要： 1-Phenylalkanecarboxylic acid derivatives, the processes for the preparation thereof and the use thereof in the treatment and/or prevention of neurodegenerative diseases such as Alzheimer's disease.
摘要翻译： 1-苯基链烷酸羧酸衍生物，其制备方法及其在治疗和/或预防神经变性疾病如阿尔茨海默氏病中的应用。
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公开(公告)号：US07507710B2
公开(公告)日：2009-03-24
申请号：US11709280
申请日：2007-02-22
IPC分类号： C07K14/00
CPC分类号： A61K39/0007 , A61K39/385 , A61K2039/505 , A61K2039/6068 , A61K2039/627 , C07K16/18
摘要： The present invention provides a recombinant immunogenic obtained by tandem multimerization of a B-cell epitope bearing fragment of Aβ42, within the active loop site of a carrier (display site), preferably bacterial thioredoxin (Yrx). Polypeptides bearing multiple copies of Aβ42 fragments, preferably with an interposed amino acid linker, were constructed and injected into mice in combination with an adjuvant. Elicited antibodies were found to selectively bind to fibrillar and/or oligomers Aβ within neuritic AD plaques.
摘要翻译： 本发明提供了通过在载体（显示位点）的活性环位点（优选细菌硫氧还蛋白（Yrx））内的Abeta42的携带B细胞表位片段的串联多聚化获得的重组免疫原性。 构建具有多个拷贝的Abeta42片段的多肽，优选用插入的氨基酸接头，并与佐剂组合注射到小鼠中。 发现引发的抗体选择性地结合神经元AD斑块中的纤维和/或寡聚体Abeta。
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