Anti-amyloid immunogenic compositions, methods and uses
    1.
    发明授权
    Anti-amyloid immunogenic compositions, methods and uses 失效
    抗淀粉样蛋白免疫原性组合物,方法和用途

    公开(公告)号:US07507710B2

    公开(公告)日:2009-03-24

    申请号:US11709280

    申请日:2007-02-22

    IPC分类号: C07K14/00

    摘要: The present invention provides a recombinant immunogenic obtained by tandem multimerization of a B-cell epitope bearing fragment of Aβ42, within the active loop site of a carrier (display site), preferably bacterial thioredoxin (Yrx). Polypeptides bearing multiple copies of Aβ42 fragments, preferably with an interposed amino acid linker, were constructed and injected into mice in combination with an adjuvant. Elicited antibodies were found to selectively bind to fibrillar and/or oligomers Aβ within neuritic AD plaques.

    摘要翻译: 本发明提供了通过在载体(显示位点)的活性环位点(优选细菌硫氧还蛋白(Yrx))内的Abeta42的携带B细胞表位片段的串联多聚化获得的重组免疫原性。 构建具有多个拷贝的Abeta42片段的多肽,优选用插入的氨基酸接头,并与佐剂组合注射到小鼠中。 发现引发的抗体选择性地结合神经元AD斑块中的纤维和/或寡聚体Abeta。

    ANTI-AMYLOID IMMUNOGENIC COMPOSITIONS, METHODS AND USES
    3.
    发明申请
    ANTI-AMYLOID IMMUNOGENIC COMPOSITIONS, METHODS AND USES 审中-公开
    抗青霉素免疫组化,方法和用途

    公开(公告)号:US20090186033A1

    公开(公告)日:2009-07-23

    申请号:US12364996

    申请日:2009-02-03

    摘要: The present invention provides a recombinant immunogenic obtained by tandem multimerization of a B-cell epitope bearing fragment of Aβ42, within the active loop site of a carrier (display site), preferably bacterial thioredoxin (Trx). Polypeptides bearing multiple copies of Aβ42 fragments, preferably with an interposed amino acid linker, were constructed and injected into mice in combination with an adjuvant. Monoclonal antibodies were made which recognize the immunogenic construct comprising a carrier bearing at least one fragment of Aβ42 within an active loop site of the carrier. The elicited antibodies were found to selectively bind to fibrillar and/or oligomers Aβ within neuritic AD plaques.

    摘要翻译: 本发明提供了通过在载体(显示位点)的活性环位点(优选细菌硫氧还蛋白(Trx))内的携带Abeta42片段的B细胞表位片段串联多聚化获得的重组免疫原性。 构建具有多个拷贝的Abeta42片段的多肽,优选用插入的氨基酸接头,并与佐剂组合注射到小鼠中。 制备了单克隆抗体,其识别包含携带载体活性环位点中至少一个Abeta42片段的载体的免疫原性构建体。 发现引发的抗体选择性地结合到神经元AD斑块内的纤维和/或寡聚体Abeta。

    Anti-amyloid immunogenic compositions, methods and uses
    4.
    发明申请
    Anti-amyloid immunogenic compositions, methods and uses 失效
    抗淀粉样蛋白免疫原性组合物,方法和用途

    公开(公告)号:US20070224190A1

    公开(公告)日:2007-09-27

    申请号:US11709280

    申请日:2007-02-22

    IPC分类号: A61K39/395 C07K16/18

    摘要: The present invention provides a recombinant immunogenic obtained by tandem multimerization of a B-cell epitope bearing fragment of Aβ42, within the active loop site of a carrier (display site), preferably bacterial thioredoxin (Trx). Polypeptides bearing multiple copies of Aβ42 fragments, preferably with an interposed amino acid linker, were constructed and injected into mice in combination with an adjuvant. Elicited antibodies were found to selectively bind to fibrillar and/or oligomers Aβ within neuritic AD plaques.

    摘要翻译: 本发明提供了通过在载体(显示位点)的活性环位点(优选细菌硫氧还蛋白(Trx))内的携带Abeta42片段的B细胞表位片段串联多聚化获得的重组免疫原性。 构建具有多个拷贝的Abeta42片段的多肽,优选用插入的氨基酸接头,并与佐剂组合注射到小鼠中。 发现引发的抗体选择性地结合神经元AD斑块中的纤维和/或寡聚体Abeta。