公开(公告)号：US20110319959A1

公开(公告)日：2011-12-29

申请号：US13229211

申请日：2011-09-09

申请人： Anthony Caparso ,  Imad Libbus ,  M. Jason Brooke ,  Kent Lee ,  Jonathan Kwok ,  Yachuan Pu

发明人： Anthony Caparso ,  Imad Libbus ,  M. Jason Brooke ,  Kent Lee ,  Jonathan Kwok ,  Yachuan Pu

IPC分类号： A61N1/36

CPC分类号： A61N1/3601 ,  A61N1/36114

摘要： A system, device and method for neural control of respiration are provided. One aspect of this disclosure relates to an implantable medical device for sensing and controlling respiration during incidence of central respiratory diseases. According to various embodiments, the device includes a sensing circuit to receive sensed signals representative of an incidence of a central respiratory disease. The device also includes a neural stimulator adapted to generate neural stimulation signals, and a controller to communicate with the sensing circuit and to control the neural stimulator to stimulate a desired neural target in response to the detection of the incidence of a central respiratory disease. In an embodiment, the device includes a plurality of sensors which are adapted to monitor physiological parameters to detect the incidence of a central respiratory disease and to send signals to the sensing circuit. Other aspects and embodiments are provided herein.

摘要翻译： 提供了一种用于呼吸神经控制的系统，装置和方法。 本公开的一个方面涉及用于在中枢呼吸系统疾病发作期间感测和控制呼吸的可植入医疗装置。 根据各种实施例，该装置包括感测电路，用于接收代表中枢呼吸系统疾病发生率的感测信号。 该装置还包括适于产生神经刺激信号的神经刺激器，以及响应于检测到中枢性呼吸系统疾病发生率而控制器与感测电路通信并控制神经刺激器以刺激所需神经靶标。 在一个实施例中，该装置包括多个传感器，其适于监测生理参数以检测中枢性呼吸系统疾病的发生并向感测电路发送信号。 本文提供了其它方面和实施例。

公开(公告)号：US07672728B2

公开(公告)日：2010-03-02

申请号：US11320500

申请日：2005-12-28

申请人： Imad Libbus ,  Anthony Caparso ,  M. Jason Brooke ,  Jonathan Kwok ,  Kent Lee ,  Yachuan Pu

发明人： Imad Libbus ,  Anthony Caparso ,  M. Jason Brooke ,  Jonathan Kwok ,  Kent Lee ,  Yachuan Pu

IPC分类号： A61N1/00

CPC分类号： A61N1/36185 ,  A61N1/3611

摘要： Various aspects relate to an implantable device. Various device embodiments include at least one sensor for use in detecting sleep disordered breathing, a pulse generator adapted to deliver a first electrical signal through at least one electrode to stimulate a neural target, and a controller adapted to communicate with the at least one sensor and with the pulse generator. The controller is adapted to detect sleep disordered breathing using the at least one sensor and provide a therapy for sleep disordered breathing in response to a detected apneic event. The therapy for sleep disordered breathing is adapted to deliver the first electrical signal through the at least one electrode to induce a cough reflex to terminate the apneic event. Various embodiments stimulate a superior laryngeal nerve, various embodiments stimulate a recurrent laryngeal nerve, and various embodiments stimulate a vagus nerve. Other aspects and embodiments are provided herein.

公开(公告)号：US08036750B2

公开(公告)日：2011-10-11

申请号：US11151122

申请日：2005-06-13

申请人： Anthony Caparso ,  Imad Libbus ,  M. Jason Brooke ,  Kent Lee ,  Jonathan Kwok ,  Yachuan Pu

发明人： Anthony Caparso ,  Imad Libbus ,  M. Jason Brooke ,  Kent Lee ,  Jonathan Kwok ,  Yachuan Pu

IPC分类号： A61N1/18

CPC分类号： A61N1/3601 ,  A61N1/36114

摘要： A system, device and method for neural control of respiration are provided. One aspect of this disclosure relates to an implantable medical device for sensing and controlling respiration during incidence of central respiratory diseases. According to various embodiments, the device includes a sensing circuit to receive sensed signals representative of an incidence of a central respiratory disease. The device also includes a neural stimulator adapted to generate neural stimulation signals, and a controller to communicate with the sensing circuit and to control the neural stimulator to stimulate a desired neural target in response to the detection of the incidence of a central respiratory disease. In an embodiment, the device includes a plurality of sensors which are adapted to monitor physiological parameters to detect the incidence of a central respiratory disease and to send signals to the sensing circuit. Other aspects and embodiments are provided herein.

摘要翻译： 提供了一种用于呼吸神经控制的系统，装置和方法。 本公开的一个方面涉及用于在中枢呼吸系统疾病发作期间感测和控制呼吸的可植入医疗装置。 根据各种实施例，该装置包括感测电路，用于接收代表中枢呼吸系统疾病发生率的感测信号。 该装置还包括适于产生神经刺激信号的神经刺激器，以及响应于检测到中枢性呼吸系统疾病发生率而控制器与感测电路通信并控制神经刺激器以刺激所需神经靶标。 在一个实施例中，该装置包括多个传感器，其适于监测生理参数以检测中枢性呼吸系统疾病的发生并向感测电路发送信号。 本文提供了其它方面和实施例。

公开(公告)号：US20120323292A1

公开(公告)日：2012-12-20

申请号：US13596595

申请日：2012-08-28

申请人： Anthony Caparso ,  Imad Libbus ,  M. Jason Brooke ,  Kent Lee ,  Jonathan Kwok ,  Yachuan Pu

发明人： Anthony Caparso ,  Imad Libbus ,  M. Jason Brooke ,  Kent Lee ,  Jonathan Kwok ,  Yachuan Pu

IPC分类号： A61N1/36

CPC分类号： A61N1/3601 ,  A61N1/36114

摘要： A system, device and method for neural control of respiration are provided. One aspect of this disclosure relates to an implantable medical device for sensing and controlling respiration during incidence of central respiratory diseases. According to various embodiments, the device includes a sensing circuit to receive sensed signals representative of an incidence of a central respiratory disease. The device also includes a neural stimulator adapted to generate neural stimulation signals, and a controller to communicate with the sensing circuit and to control the neural stimulator to stimulate a desired neural target in response to the detection of the incidence of a central respiratory disease. In an embodiment, the device includes a plurality of sensors which are adapted to monitor physiological parameters to detect the incidence of a central respiratory disease and to send signals to the sensing circuit. Other aspects and embodiments are provided herein.

摘要翻译： 提供了一种用于呼吸神经控制的系统，装置和方法。 本公开的一个方面涉及用于在中枢呼吸系统疾病发作期间感测和控制呼吸的可植入医疗装置。 根据各种实施例，该装置包括感测电路，用于接收代表中枢呼吸系统疾病发生率的感测信号。 该装置还包括适于产生神经刺激信号的神经刺激器，以及响应于检测到中枢性呼吸系统疾病发生率而控制器与感测电路通信并控制神经刺激器以刺激所需神经靶标。 在一个实施例中，该装置包括多个传感器，其适于监测生理参数以检测中枢性呼吸系统疾病的发生并向感测电路发送信号。 本文提供了其它方面和实施例。

公开(公告)号：US20100121406A1

公开(公告)日：2010-05-13

申请号：US12691392

申请日：2010-01-21

申请人： Imad Libbus ,  Anthony Caparso ,  M. Jason Brooke ,  Jonathan Kwok ,  Kent Lee ,  Yachuan Pu

发明人： Imad Libbus ,  Anthony Caparso ,  M. Jason Brooke ,  Jonathan Kwok ,  Kent Lee ,  Yachuan Pu

IPC分类号： A61N1/36

CPC分类号： A61N1/36185 ,  A61N1/3611

摘要： Various aspects relate to an implantable device. Various device embodiments include at least one sensor for use in detecting sleep disordered breathing, a pulse generator adapted to deliver a first electrical signal through at least one electrode to stimulate a neural target, and a controller adapted to communicate with the at least one sensor and with the pulse generator. The controller is adapted to detect sleep disordered breathing using the at least one sensor and provide a therapy for sleep disordered breathing in response to a detected apneic event. The therapy for sleep disordered breathing is adapted to deliver the first electrical signal through the at least one electrode to induce a cough reflex to terminate the apneic event. Various embodiments stimulate a superior laryngeal nerve, various embodiments stimulate a recurrent laryngeal nerve, and various embodiments stimulate a vagus nerve. Other aspects and embodiments are provided herein.

摘要翻译： 各种方面涉及可植入装置。 各种装置实施例包括用于检测睡眠无序呼吸的至少一个传感器，适于通过至少一个电极传递第一电信号以刺激神经靶的脉冲发生器，以及适于与至少一个传感器和 与脉冲发生器。 所述控制器适于使用所述至少一个传感器检测睡眠呼吸障碍，并响应于检测到的呼吸暂停事件提供针对睡眠呼吸障碍的治疗。 用于睡眠呼吸紊乱的治疗适于通过至少一个电极传递第一电信号以引起咳嗽反射以终止呼吸暂停事件。 各种实施方案刺激上喉神经，各种实施方案刺激复发性喉神经，并且各种实施方案刺激迷走神经。 本文提供了其它方面和实施例。

公开(公告)号：US08401651B2

公开(公告)日：2013-03-19

申请号：US13229211

申请日：2011-09-09

申请人： Anthony V. Caparso ,  Imad Libbus ,  M. Jason Brooke ,  Kent Lee ,  Jonathan Kwok ,  Yachuan Pu

发明人： Anthony V. Caparso ,  Imad Libbus ,  M. Jason Brooke ,  Kent Lee ,  Jonathan Kwok ,  Yachuan Pu

IPC分类号： A61N1/18

CPC分类号： A61N1/3601 ,  A61N1/36114

摘要： A system, device and method for neural control of respiration are provided. One aspect of this disclosure relates to an implantable medical device for sensing and controlling respiration during incidence of central respiratory diseases. According to various embodiments, the device includes a sensing circuit to receive sensed signals representative of an incidence of a central respiratory disease. The device also includes a neural stimulator adapted to generate neural stimulation signals, and a controller to communicate with the sensing circuit and to control the neural stimulator to stimulate a desired neural target in response to the detection of the incidence of a central respiratory disease. In an embodiment, the device includes a plurality of sensors which are adapted to monitor physiological parameters to detect the incidence of a central respiratory disease and to send signals to the sensing circuit. Other aspects and embodiments are provided herein.

公开(公告)号：US07797050B2

公开(公告)日：2010-09-14

申请号：US12691392

申请日：2010-01-21

申请人： Imad Libbus ,  Anthony V. Caparso ,  M. Jason Brooke ,  Jonathan Kwok ,  Kent Lee ,  Yachuan Pu

发明人： Imad Libbus ,  Anthony V. Caparso ,  M. Jason Brooke ,  Jonathan Kwok ,  Kent Lee ,  Yachuan Pu

IPC分类号： A61N1/00

CPC分类号： A61N1/36185 ,  A61N1/3611

摘要： Various aspects relate to an implantable device. Various device embodiments include at least one sensor for use in detecting sleep disordered breathing, a pulse generator adapted to deliver a first electrical signal through at least one electrode to stimulate a neural target, and a controller adapted to communicate with the at least one sensor and with the pulse generator. The controller is adapted to detect sleep disordered breathing using the at least one sensor and provide a therapy for sleep disordered breathing in response to a detected apneic event. The therapy for sleep disordered breathing is adapted to deliver the first electrical signal through the at least one electrode to induce a cough reflex to terminate the apneic event. Various embodiments stimulate a superior laryngeal nerve, various embodiments stimulate a recurrent laryngeal nerve, and various embodiments stimulate a vagus nerve. Other aspects and embodiments are provided herein.

摘要翻译： 各种方面涉及可植入装置。 各种装置实施例包括用于检测睡眠无序呼吸的至少一个传感器，适于通过至少一个电极传递第一电信号以刺激神经靶的脉冲发生器，以及适于与至少一个传感器和 与脉冲发生器。 所述控制器适于使用所述至少一个传感器检测睡眠呼吸障碍，并响应于检测到的呼吸暂停事件提供针对睡眠呼吸障碍的治疗。 用于睡眠呼吸紊乱的治疗适于通过至少一个电极传递第一电信号以引起咳嗽反射以终止呼吸暂停事件。 各种实施方案刺激上喉神经，各种实施方案刺激复发性喉神经，并且各种实施方案刺激迷走神经。 本文提供了其它方面和实施例。

公开(公告)号：US08560072B2

公开(公告)日：2013-10-15

申请号：US13596595

申请日：2012-08-28

申请人： Anthony V. Caparso ,  Imad Libbus ,  M. Jason Brooke ,  Kent Lee ,  Jonathan Kwok ,  Yachuan Pu

发明人： Anthony V. Caparso ,  Imad Libbus ,  M. Jason Brooke ,  Kent Lee ,  Jonathan Kwok ,  Yachuan Pu

IPC分类号： A61N1/18

CPC分类号： A61N1/3601 ,  A61N1/36114

摘要： A system, device and method for neural control of respiration are provided. One aspect of this disclosure relates to an implantable medical device for sensing and controlling respiration during incidence of central respiratory diseases. According to various embodiments, the device includes a sensing circuit to receive sensed signals representative of an incidence of a central respiratory disease. The device also includes a neural stimulator adapted to generate neural stimulation signals, and a controller to communicate with the sensing circuit and to control the neural stimulator to stimulate a desired neural target in response to the detection of the incidence of a central respiratory disease. In an embodiment, the device includes a plurality of sensors which are adapted to monitor physiological parameters to detect the incidence of a central respiratory disease and to send signals to the sensing circuit. Other aspects and embodiments are provided herein.

摘要翻译： 提供了一种用于呼吸神经控制的系统，装置和方法。 本公开的一个方面涉及用于在中枢呼吸系统疾病发作期间感测和控制呼吸的可植入医疗装置。 根据各种实施例，该装置包括感测电路，用于接收代表中枢呼吸系统疾病发生率的感测信号。 该装置还包括适于产生神经刺激信号的神经刺激器，以及响应于检测到中枢性呼吸系统疾病发生率而控制器与感测电路通信并控制神经刺激器以刺激所需神经靶标。 在一个实施例中，该装置包括多个传感器，其适于监测生理参数以检测中枢性呼吸系统疾病的发生并向感测电路发送信号。 本文提供了其它方面和实施例。

公开(公告)号：US20070150006A1

公开(公告)日：2007-06-28

申请号：US11320500

申请日：2005-12-28

申请人： Imad Libbus ,  Anthony Caparso ,  M. Brooke ,  Jonathan Kwok ,  Kent Lee ,  Yachuan Pu

发明人： Imad Libbus ,  Anthony Caparso ,  M. Brooke ,  Jonathan Kwok ,  Kent Lee ,  Yachuan Pu

IPC分类号： A61N1/32

CPC分类号： A61N1/36185 ,  A61N1/3611

摘要： Various aspects relate to an implantable device. Various device embodiments include at least one sensor for use in detecting sleep disordered breathing, a pulse generator adapted to deliver a first electrical signal through at least one electrode to stimulate a neural target, and a controller adapted to communicate with the at least one sensor and with the pulse generator. The controller is adapted to detect sleep disordered breathing using the at least one sensor and provide a therapy for sleep disordered breathing in response to a detected apneic event. The therapy for sleep disordered breathing is adapted to deliver the first electrical signal through the at least one electrode to induce a cough reflex to terminate the apneic event. Various embodiments stimulate a superior laryngeal nerve, various embodiments stimulate a recurrent laryngeal nerve, and various embodiments stimulate a vagus nerve. Other aspects and embodiments are provided herein.

摘要翻译： 各种方面涉及可植入装置。 各种装置实施例包括用于检测睡眠无序呼吸的至少一个传感器，适于通过至少一个电极传递第一电信号以刺激神经靶的脉冲发生器，以及适于与至少一个传感器和 与脉冲发生器。 所述控制器适于使用所述至少一个传感器检测睡眠呼吸障碍，并响应于检测到的呼吸暂停事件提供针对睡眠呼吸障碍的治疗。 用于睡眠呼吸紊乱的治疗适于通过至少一个电极传递第一电信号以引起咳嗽反射以终止呼吸暂停事件。 各种实施方案刺激上喉神经，各种实施方案刺激复发性喉神经，并且各种实施方案刺激迷走神经。 本文提供了其它方面和实施例。

公开(公告)号：US20060282131A1

公开(公告)日：2006-12-14

申请号：US11151122

申请日：2005-06-13

申请人： Anthony Caparso ,  Imad Libbus ,  M. Brooke ,  Kent Lee ,  Jonathan Kwok ,  Yachuan Pu

发明人： Anthony Caparso ,  Imad Libbus ,  M. Brooke ,  Kent Lee ,  Jonathan Kwok ,  Yachuan Pu

IPC分类号： A61N1/00

CPC分类号： A61N1/3601 ,  A61N1/36114

摘要： A system, device and method for neural control of respiration are provided. One aspect of this disclosure relates to an implantable medical device for sensing and controlling respiration during incidence of central respiratory diseases. According to various embodiments, the device includes a sensing circuit to receive sensed signals representative of an incidence of a central respiratory disease. The device also includes a neural stimulator adapted to generate neural stimulation signals, and a controller to communicate with the sensing circuit and to control the neural stimulator to stimulate a desired neural target in response to the detection of the incidence of a central respiratory disease. In an embodiment, the device includes a plurality of sensors which are adapted to monitor physiological parameters to detect the incidence of a central respiratory disease and to send signals to the sensing circuit. Other aspects and embodiments are provided herein.