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公开(公告)号：US20170002096A1
公开(公告)日：2017-01-05
申请号：US15167476
申请日：2016-05-27
申请人： ImmunoGen, Inc.
CPC分类号： C07K16/46 , A61K47/60 , A61K47/6803 , A61K47/6849 , A61K47/6851 , A61K47/6855 , A61K47/6863 , A61K47/6891 , C07D213/71 , C07K2317/21 , C07K2317/24
摘要： This invention describes a method of conjugating a cell binding agent such as an antibody with an effector group (e.g., a cytotoxic agent) or a reporter group (e.g., a radionuclide), whereby the reporter or effector group is first reacted with a bifunctional linker and the mixture is then used without purification for the conjugation reaction with the cell binding agent. The method described in this invention is advantageous for preparation of stably-linked conjugates of cell binding agents, such as antibodies with effector or reporter groups. This conjugation method provides in high yields conjugates of high purity and homogeneity that are without inter-chain cross-linking and inactivated linker residues
摘要翻译： 本发明描述了将细胞结合剂如抗体与效应基团（例如，细胞毒性剂）或报告基团（例如，放射性核素）缀合的方法，由此报告物或效应基团首先与双官能接头 然后将混合物不经纯化用于与细胞结合剂的缀合反应。 本发明描述的方法有利于制备稳定连接的细胞结合剂的缀合物，例如具有效应物或报道基团的抗体。 这种共轭方法提供了高产率和高度均一性的缀合物，其不具有链间交联和失活的接头残基
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公开(公告)号：US20210163625A1
公开(公告)日：2021-06-03
申请号：US17031151
申请日：2020-09-24
申请人： ImmunoGen, Inc.
发明人： Brenda A. KELLOGG , Rajeeva SINGH , Ravi V. CHARI
IPC分类号： C07K16/46 , C07D213/71 , A61K47/68 , A61K47/60 , C07D498/14
摘要： This invention describes a method of conjugating a cell binding agent such as an antibody with an effector group (e.g., a cytotoxic agent) or a reporter group (e.g., a radionuclide), whereby the reporter or effector group is first reacted with a bifunctional linker and the mixture is then used without purification for the conjugation reaction with the cell binding agent. The method described in this invention is advantageous for preparation of stably-linked conjugates of cell binding agents, such as antibodies with effector or reporter groups. This conjugation method provides in high yields conjugates of high purity and homogeneity that are without inter-chain cross-linking and inactivated linker residues.
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公开(公告)号：US20160324980A1
公开(公告)日：2016-11-10
申请号：US15097979
申请日：2016-04-13
申请人： ImmunoGen, Inc.
CPC分类号： C07K16/30 , A61K31/5517 , A61K45/06 , A61K47/545 , A61K47/6803 , A61K47/6849 , A61K47/6851 , A61K47/6867 , A61K2039/505 , C07D487/04 , C07D519/00 , C07K2317/24 , C07K2317/92 , C07K2317/94
摘要： The present invention is directed to methods of preparing a conjugate of a cell-binding agent and a drug (such as a cytotoxic compound). The methods comprise the use of an imine reactive compound to enable efficient conjugations of cytotoxic compounds with cell binding agents.
摘要翻译： 本发明涉及制备细胞结合剂和药物（例如细胞毒性化合物）的缀合物的方法。 所述方法包括使用亚胺反应性化合物以使细胞毒性化合物与细胞结合剂的有效缀合。
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公开(公告)号：US20140179906A1
公开(公告)日：2014-06-26
申请号：US14095579
申请日：2013-12-03
申请人： ImmunoGen, Inc.
CPC分类号： C07K16/46 , A61K47/60 , A61K47/6803 , A61K47/6849 , A61K47/6851 , A61K47/6855 , A61K47/6863 , A61K47/6891 , C07D213/71 , C07K2317/21 , C07K2317/24
摘要： This invention describes a method of conjugating a cell binding agent such as an antibody with an effector group (e.g., a cytotoxic agent) or a reporter group (e.g., a radionuclide), whereby the reporter or effector group is first reacted with a bifunctional linker and the mixture is then used without purification for the conjugation reaction with the cell binding agent. The method described in this invention is advantageous for preparation of stably-linked conjugates of cell binding agents, such as antibodies with effector or reporter groups. This conjugation method provides in high yields conjugates of high purity and homogeneity that are without inter-chain cross-linking and inactivated linker residues
摘要翻译： 本发明描述了将细胞结合剂如抗体与效应基团（例如，细胞毒性剂）或报告基团（例如，放射性核素）缀合的方法，由此报告物或效应基团首先与双官能接头 然后将混合物不经纯化用于与细胞结合剂的缀合反应。 本发明描述的方法有利于制备稳定连接的细胞结合剂的缀合物，例如具有效应物或报道基团的抗体。 这种共轭方法提供了高产率和高度均一性的缀合物，其不具有链间交联和失活的接头残基
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