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公开(公告)号：USRE49918E1
公开(公告)日：2024-04-16
申请号：US17316241
申请日：2021-05-10
申请人： IMMUNOGEN, INC.
IPC分类号： C07K16/30 , A61K31/5517 , A61K39/00 , A61K45/06 , A61K47/54 , A61K47/68 , A61P35/00 , C07D487/04 , C07D519/00
CPC分类号： C07K16/30 , A61K31/5517 , A61K45/06 , A61K47/545 , A61K47/6803 , A61K47/6849 , A61K47/6851 , A61K47/6867 , A61P35/00 , C07D487/04 , C07D519/00 , A61K2039/505 , C07K2317/24 , C07K2317/92 , C07K2317/94
摘要： The invention relates to novel benzodiazepine derivatives with antiproliferative activity and more specifically to novel benzodiazepine compounds of formula (I)-(VII). The invention also provides conjugates of the benzodiazepine compounds linked to a cell-binding agent. The invention further provides compositions and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the compounds or conjugates of the invention.
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公开(公告)号：US11229639B2
公开(公告)日：2022-01-25
申请号：US17032219
申请日：2020-09-25
申请人： IMMUNOGEN, INC.
发明人： Ravi V. J. Chari , Wayne C. Widdison , Wei Li , David P. Pleynet
IPC分类号： A61K31/4745 , A61K47/68 , A61P35/00 , A61K39/395 , C07D491/22
摘要： Disclosed herein are novel cytotoxic compounds, and cytotoxic conjugates comprising these cytotoxic compounds and cell-binding agents. More specifically, this disclosure relates to novel camptothecin derivatives thereof, intermediates thereof, conjugates thereof, and pharmaceutically acceptable salts thereof, which are useful as medicaments, in particular as anti-proliferative agents (anticancer agents).
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公开(公告)号：US20210238301A1
公开(公告)日：2021-08-05
申请号：US17143738
申请日：2021-01-07
申请人： IMMUNOGEN, INC.
IPC分类号： C07K16/28 , C07D498/04 , C07D519/00 , A61K47/60 , A61K47/68 , A61P35/00 , C07D487/04 , A61K45/06 , A61K31/5517 , A61K38/07 , C07K5/103 , C07K5/02 , C07K16/46 , C07K19/00
摘要： The invention relates to novel benzodiazepine derivatives with antiproliferative activity and more specifically to novel benzodiazepines of formula (I) and (II), in which the diazepine ring (B) is fused with a heterocyclic ring (CD), wherein the heterocyclic ring is bicyclic or a compound of formula (III), in which the diazepine ring (B) is fused with a heterocyclic ring (C), wherein the heterocyclic ring is monocyclic. The invention provides cytotoxic dimers of these compounds. The invention also provides conjugates of the monomers and the dimers. The invention further provides compositions and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the compounds or conjugates of the invention. The invention further relates to methods of using the compounds or conjugates for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.
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公开(公告)号：US10208127B2
公开(公告)日：2019-02-19
申请号：US15974089
申请日：2018-05-08
申请人： ImmunoGen, Inc.
发明人： Wei Li , Nathan Elliott Fishkin , Robert Yongxin Zhao , Michael Louis Miller , Ravi V. J. Chari
IPC分类号： C07D487/04 , C07K16/28 , C07K5/103 , A61K31/5517 , A61K45/06 , C07D519/00 , C07D498/04 , A61K47/68 , A61K47/60 , C07K19/00 , C07K16/46 , C07K5/02 , A61P35/00 , A61K38/07
摘要： The invention relates to novel benzodiazepine derivatives with antiproliferative activity and more specifically to novel benzodiazepines of formula (I) and (II), in which the diazepine ring (B) is fused with a heterocyclic ring (CD), wherein the heterocyclic ring is bicyclic or a compound of formula (III), in which the diazepine ring (B) is fused with a heterocyclic ring (C), wherein the heterocyclic ring is monocyclic. The invention provides cytotoxic dimers of these compounds. The invention also provides conjugates of the monomers and the dimers. The invention further provides compositions and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the compounds or conjugates of the invention. The invention further relates to methods of using the compounds or conjugates for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.
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公开(公告)号：US10179818B2
公开(公告)日：2019-01-15
申请号：US15645597
申请日：2017-07-10
申请人： IMMUNOGEN, INC.
IPC分类号： C07D487/04 , C07K16/30 , C07D519/00 , A61K45/06 , A61K31/5517 , A61K47/54 , A61K47/68 , A61K39/00
摘要： The invention relates to novel benzodiazepine derivatives with antiproliferative activity and more specifically to novel benzodiazepine compounds of formula (I)-(VII). The invention also provides conjugates of the benzodiazepine compounds linked to a cell-binding agent. The invention further provides compositions and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the compounds or conjugates of the invention.
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公开(公告)号：US09868791B2
公开(公告)日：2018-01-16
申请号：US15097979
申请日：2016-04-13
申请人： ImmunoGen, Inc.
IPC分类号： A61K38/00 , C07K16/30 , C07D487/04 , C07D519/00 , A61K45/06 , A61K31/5517 , A61K47/54 , A61K47/68 , A61K39/00
CPC分类号： C07K16/30 , A61K31/5517 , A61K45/06 , A61K47/545 , A61K47/6803 , A61K47/6849 , A61K47/6851 , A61K47/6867 , A61K2039/505 , C07D487/04 , C07D519/00 , C07K2317/24 , C07K2317/92 , C07K2317/94
摘要： The present invention is directed to methods of preparing a conjugate of a cell-binding agent and a drug (such as a cytotoxic compound). The methods comprise the use of an imine reactive compound to enable efficient conjugations of cytotoxic compounds with cell binding agents.
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公开(公告)号：US20170327486A1
公开(公告)日：2017-11-16
申请号：US15496775
申请日：2017-04-25
申请人： IMMUNOGEN, INC.
发明人： Wei Li , Robert Yongxin Zhao
IPC分类号： C07D401/12 , C07D207/46 , C07D207/452 , C07D213/71
CPC分类号： C07D401/12 , C07B2200/13 , C07D207/452 , C07D207/46 , C07D213/71
摘要： Processes for the preparation of charged crosslinkers bearing a sulfonic acid moiety are disclosed. These procedures also optionally include methods to convert the resulting products to substantially a single salt form.
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公开(公告)号：US09663492B2
公开(公告)日：2017-05-30
申请号：US14969720
申请日：2015-12-15
申请人： ImmunoGen, Inc.
发明人： Wei Li , Robert Yongxin Zhao
IPC分类号： C07D401/12 , C07D207/452 , C07D207/46 , C07D213/71
CPC分类号： C07D401/12 , C07B2200/13 , C07D207/452 , C07D207/46 , C07D213/71
摘要： Processes for the preparation of charged crosslinkers bearing a sulfonic acid moiety are disclosed. These procedures also optionally include methods to convert the resulting products to substantially a single salt form.
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公开(公告)号：US20170044266A1
公开(公告)日：2017-02-16
申请号：US15221255
申请日：2016-07-27
申请人： ImmunoGen, Inc.
IPC分类号： C07K16/30 , A61K47/48 , A61K31/5517 , C07D519/00
CPC分类号： C07K16/30 , A61K31/5517 , A61K45/06 , A61K47/545 , A61K47/6803 , A61K47/6849 , A61K47/6851 , A61K47/6867 , A61K2039/505 , C07D487/04 , C07D519/00 , C07K2317/24 , C07K2317/92 , C07K2317/94
摘要： The invention relates to novel benzodiazepine derivatives with antiproliferative activity and more specifically to novel benzodiazepine compounds of formula (I)-(VII). The invention also provides conjugates of the benzodiazepine compounds linked to a cell-binding agent. The invention further provides compositions and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the compounds or conjugates of the invention.
摘要翻译： 本发明涉及具有抗增殖活性的新型苯并二氮杂衍生物，更具体地涉及式（I） - （VII）的新型苯并二氮杂化合物。 本发明还提供了与细胞结合剂连接的苯并二氮杂类化合物的缀合物。 本发明还提供了使用本发明的化合物或缀合物来抑制哺乳动物异常细胞生长或治疗增殖性病症的组合物和方法。
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公开(公告)号：US20160324980A1
公开(公告)日：2016-11-10
申请号：US15097979
申请日：2016-04-13
申请人： ImmunoGen, Inc.
CPC分类号： C07K16/30 , A61K31/5517 , A61K45/06 , A61K47/545 , A61K47/6803 , A61K47/6849 , A61K47/6851 , A61K47/6867 , A61K2039/505 , C07D487/04 , C07D519/00 , C07K2317/24 , C07K2317/92 , C07K2317/94
摘要： The present invention is directed to methods of preparing a conjugate of a cell-binding agent and a drug (such as a cytotoxic compound). The methods comprise the use of an imine reactive compound to enable efficient conjugations of cytotoxic compounds with cell binding agents.
摘要翻译： 本发明涉及制备细胞结合剂和药物（例如细胞毒性化合物）的缀合物的方法。 所述方法包括使用亚胺反应性化合物以使细胞毒性化合物与细胞结合剂的有效缀合。
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