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公开(公告)号：US11730903B2
公开(公告)日：2023-08-22
申请号：US16664588
申请日：2019-10-25
CPC分类号： A61M15/08 , A61M11/02 , A61M2202/0468 , A61M2202/064 , A61M2205/073 , A61M2205/8225
摘要： A compound delivery device for delivering a plume derived from a propellant and a drug formulation. The drug formulation is in an intranasal dosage form in the form of powder, suspension, dispersion or liquid. The propelled intranasal dosage form is deposited within the olfactory region of the nasal cavity. The drug deposited within the olfactory region is delivered to the brain avoiding the blood-brain-barrier. Hydrofluoroalkane propellant from a pressurized canister is channeled to a diffuser and drug-containing chamber where the intra-nasal dosage form is aerosolized. The aerosolized intra-nasal dosage form passes through a nozzle thus delivering a plume to the olfactory region of a user's nasal cavity.
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公开(公告)号：US11890412B2
公开(公告)日：2024-02-06
申请号：US17164371
申请日：2021-02-01
发明人： John D. Hoekman , Michael Hite , Alan Brunelle , Joel Relethford
CPC分类号： A61M15/08 , A61M15/0021 , A61M16/127 , B05B1/14 , B05B7/08 , A61M16/208 , A61M2202/064 , A61M2210/0612 , A61M2210/0618 , A61M2210/1067 , A61M2210/1475
摘要： A nozzle for use in delivering a mixture of aerosol propellant and drug formulation. The nozzle includes a drug product inlet configured to receive a mixture of aerosolized propellant and an intranasal dosage form. The inlet is disposed at the proximal end. A nozzle body is secured to the drug product inlet. Two or more channels are disposed within the body. Two or more orifice apertures are disposed at the distal end of the nozzle.
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